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Crosslinking of DNA, the Glossary

In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA, forming a covalent linkage between them.^[1]

50 relations: Acetaldehyde, Aldehyde, Alkylating antineoplastic agent, Amine, Apoptosis, Base excision repair, BRCA1, Cancer, Carmustine, Cell death, Chemotherapy, Cisplatin, Cytotoxicity, DNA, DNA repair, DNA replication, Endonuclease, ERCC1, Eukaryote, Formaldehyde, Furan, Genetics, Homologous chromosome, Homologous recombination, Intercalation (biochemistry), Lipid peroxidation, Malondialdehyde, Meiosis, Mitomycin C, Neoplasm, Nitrogen mustard, Nitrous acid, Non-small-cell lung cancer, Nucleotide, Nucleotide excision repair, Prostaglandin, Psoralen, Psoriasis, PUVA therapy, Pyrone, Quinone, RecA, Sister chromatids, Thymidine, Thymine, Topoisomerase, Transcription (biology), Ultraviolet, UvrABC endonuclease, Vitiligo.

Acetaldehyde

Acetaldehyde (IUPAC systematic name ethanal) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated as MeCHO.

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Aldehyde

In organic chemistry, an aldehyde is an organic compound containing a functional group with the structure.

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Alkylating antineoplastic agent

An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA.

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Amine

In chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.

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Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.

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Base excision repair

Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle.

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BRCA1

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Carmustine

Carmustine, sold under the brand name BiCNU among others, is a medication used mainly for chemotherapy.

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Cell death

Cell death is the event of a biological cell ceasing to carry out its functions.

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Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.

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Cisplatin

Cisplatin is a chemical compound with formula cis-.

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Cytotoxicity

Cytotoxicity is the quality of being toxic to cells.

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DNA

Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. Crosslinking of DNA and DNA repair are DNA.

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DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. Crosslinking of DNA and DNA replication are DNA and genetics techniques.

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Endonuclease

In molecular biology, endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain (namely DNA or RNA).

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ERCC1

DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene.

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Eukaryote

The eukaryotes constitute the domain of Eukarya or Eukaryota, organisms whose cells have a membrane-bound nucleus.

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Formaldehyde

Formaldehyde (systematic name methanal) is an organic compound with the chemical formula and structure, more precisely.

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Furan

Furan is a heterocyclic organic compound, consisting of a five-membered aromatic ring with four carbon atoms and one oxygen atom.

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Genetics

Genetics is the study of genes, genetic variation, and heredity in organisms.

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Homologous chromosome

A pair of homologous chromosomes, or homologs, is a set of one maternal and one paternal chromosome that pair up with each other inside a cell during fertilization.

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Homologous recombination

Homologous recombination is a type of genetic recombination in which genetic information is exchanged between two similar or identical molecules of double-stranded or single-stranded nucleic acids (usually DNA as in cellular organisms but may be also RNA in viruses).

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Intercalation (biochemistry)

In biochemistry, intercalation is the insertion of molecules between the planar bases of deoxyribonucleic acid (DNA).

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Lipid peroxidation

Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, resulting in the formation of peroxide and hydroperoxide derivatives.

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Malondialdehyde

Malondialdehyde belong to the class of β-dicarbonyls.

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Meiosis

Meiosis ((since it is a reductional division) is a special type of cell division of germ cells in sexually-reproducing organisms that produces the gametes, the sperm or egg cells. It involves two rounds of division that ultimately result in four cells, each with only one copy of each chromosome (haploid).

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Mitomycin C

Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity.

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Neoplasm

A neoplasm is a type of abnormal and excessive growth of tissue.

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Nitrogen mustard

Nitrogen mustards (NMs) are cytotoxic organic compounds with the bis(2-chloroethyl)amino ((ClC2H4)2NR) functional group.

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Nitrous acid

Nitrous acid (molecular formula) is a weak and monoprotic acid known only in solution, in the gas phase, and in the form of nitrite salts.

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Non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC).

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Nucleotide

Nucleotides are organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. Crosslinking of DNA and Nucleotide are DNA.

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Nucleotide excision repair

Nucleotide excision repair is a DNA repair mechanism.

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Prostaglandin

Prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids that have diverse hormone-like effects in animals.

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Psoralen

Psoralen (also called psoralene) is the parent compound in a family of naturally occurring organic compounds known as the linear furanocoumarins.

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Psoriasis

Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin.

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PUVA therapy

PUVA (psoralen and UVA) is an ultraviolet light therapy treatment for skin diseases: vitiligo, eczema, psoriasis, graft-versus-host disease, mycosis fungoides, large plaque parapsoriasis, and cutaneous T-cell lymphoma, using the sensitizing effects of the drug psoralen.

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References

[1] https://en.wikipedia.org/wiki/Crosslinking_of_DNA

Also known as DNA crosslink, DNA crosslinking, Interstrand crosslinks, Intrastrand crosslink.

Crosslinking of DNA, the Glossary

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References