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Cyanodothiepin, the Glossary

Cyanodothiepin (developmental code name BTS-56424) is a tricyclic antidepressant (TCA) acting as a potent and highly selective (over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin that was never marketed.^[1]

25 relations: Alpha-1 adrenergic receptor, Antidepressant, Antihistamine, Behavioural despair test, Binding selectivity, Biological activity, Cianopramine, Clomipramine, Dopamine, Dopamine receptor D1, Dopamine receptor D2, Histamine H1 receptor, Imipramine, Ligand (biochemistry), Monoamine neurotransmitter, Muscarinic acetylcholine receptor, Norepinephrine, Pharmacodynamics, Potency (pharmacology), Reuptake, Reuptake inhibitor, Sedative, Serotonin, Tricyclic antidepressant, 5-HT2A receptor.
Antihistamines
Dibenzothiepines
Selective serotonin reuptake inhibitors

Alpha-1 adrenergic receptor

alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein.

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Antidepressant

Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.

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Antihistamine

Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Cyanodothiepin and Antihistamine are Antihistamines.

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Behavioural despair test

The behavioural despair test (or Porsolt forced swimming test) is a test, centered on a rodent's response to the threat of drowning, whose result has been interpreted as measuring susceptibility to negative mood.

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Binding selectivity

In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

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Cianopramine

Cianopramine (INN) (developmental code name Ro 11-2465), also known as 3-cyanoimipramine, is a tricyclic antidepressant related to imipramine that acts as a serotonin reuptake inhibitor and weak serotonin receptor antagonist. Cyanodothiepin and Cianopramine are Abandoned drugs, Nervous system drug stubs, Nitriles, selective serotonin reuptake inhibitors and tricyclic antidepressants.

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Clomipramine

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). Cyanodothiepin and Clomipramine are Antihistamines, Dimethylamino compounds, Muscarinic antagonists and tricyclic antidepressants.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.

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Dopamine receptor D1

Dopamine receptor D1, also known as DRD1.

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Dopamine receptor D2

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.

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Histamine H1 receptor

The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.

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Imipramine

Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression. Cyanodothiepin and Imipramine are Dimethylamino compounds, Muscarinic antagonists and tricyclic antidepressants.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Monoamine neurotransmitter

Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). Examples are dopamine, norepinephrine and serotonin.

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Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator.

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Pharmacodynamics

Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).

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Potency (pharmacology)

In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.

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Reuptake

Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

See Cyanodothiepin and Reuptake

References

[1] https://en.wikipedia.org/wiki/Cyanodothiepin

Also known as BTS 56 424, BTS 56424, BTS-56,424, BTS-56424, BTS56424, C20H20N2S, Cianodosulepin, Cianodothiepin, Cyanodosulepin.

Cyanodothiepin, the Glossary

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