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Dactinomycin, the Glossary

Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer.^[1]

58 relations: Adverse drug reaction, Allergy, Anorexia (symptom), Antibiotic, Blister agent, Bone marrow suppression, Cancer, Cell biology, Chemotherapy, Chemotherapy regimen, Chromophore, Compensatory growth (organ), Cyclophosphamide, Diarrhea, DNA, DNA replication, Epimerase and racemase, Ewing sarcoma, Extravasation, Fatigue, Flow cytometry, Fluorescence, Food and Drug Administration, Gestational trophoblastic disease, H. Boyd Woodruff, Hair loss, Hydroxycarbamide, Intravenous therapy, Journal of Clinical Oncology, Kynurenine pathway, Liver disease, Merck & Co., Methyltransferase, Microscopy, Molar pregnancy, Mouth ulcer, Necrosis, Neoplasm, Ovarian cancer, Pregnancy, Radiation therapy, Radiosensitivity, Radiosensitizer, Rhabdomyosarcoma, RNA, RNA polymerase, Selman Waksman, Sequence homology, Streptomyces, Testicular cancer, ... Expand index (8 more) »
DNA intercalaters
DNA replication inhibitors
Depsipeptides
Polypeptide antibiotics

Adverse drug reaction

An adverse drug reaction (ADR) is a harmful, unintended result caused by taking medication.

See Dactinomycin and Adverse drug reaction

Allergy

Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.

See Dactinomycin and Allergy

Anorexia (symptom)

Anorexia is a medical term for a loss of appetite.

See Dactinomycin and Anorexia (symptom)

Antibiotic

An antibiotic is a type of antimicrobial substance active against bacteria.

See Dactinomycin and Antibiotic

Blister agent

A blister agent (or vesicant), is a chemical compound that causes severe skin, eye and mucosal pain and irritation.

See Dactinomycin and Blister agent

Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes).

See Dactinomycin and Bone marrow suppression

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

See Dactinomycin and Cancer

Cell biology

Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells.

See Dactinomycin and Cell biology

Chemotherapy

Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.

See Dactinomycin and Chemotherapy

Chemotherapy regimen

A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.

See Dactinomycin and Chemotherapy regimen

Chromophore

A chromophore is a molecule which absorbs light at a particular wavelength and emits color as a result.

See Dactinomycin and Chromophore

Compensatory growth (organ)

Compensatory growth is a type of regenerative growth that can take place in a number of human organs after the organs are either damaged, removed, or cease to function.

See Dactinomycin and Compensatory growth (organ)

Cyclophosphamide

Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. Dactinomycin and Cyclophosphamide are World Health Organization essential medicines.

See Dactinomycin and Cyclophosphamide

Diarrhea

Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day.

See Dactinomycin and Diarrhea

DNA

Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.

See Dactinomycin and DNA

DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

See Dactinomycin and DNA replication

Epimerase and racemase

Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules.

See Dactinomycin and Epimerase and racemase

Ewing sarcoma

Ewing sarcoma is a type of pediatric cancer that forms in bone or soft tissue.

See Dactinomycin and Ewing sarcoma

Extravasation is the leakage of a fluid out of its contained space into the surrounding the area, especially blood or blood cells from vessels.

See Dactinomycin and Extravasation

Fatigue

Fatigue describes a state of tiredness (which is not sleepiness), exhaustion or loss of energy.

See Dactinomycin and Fatigue

Flow cytometry

Flow cytometry (FC) is a technique used to detect and measure the physical and chemical characteristics of a population of cells or particles.

See Dactinomycin and Flow cytometry

Fluorescence

Fluorescence is one of two kinds of emission of light by a substance that has absorbed light or other electromagnetic radiation.

See Dactinomycin and Fluorescence

Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

See Dactinomycin and Food and Drug Administration

Gestational trophoblastic disease

Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours.

See Dactinomycin and Gestational trophoblastic disease

H. Boyd Woodruff

Harold Boyd Woodruff (July 22, 1917 – January 19, 2017) was an American soil microbiologist and a member of the National Academy of Sciences.

See Dactinomycin and H. Boyd Woodruff

Hair loss

Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body.

See Dactinomycin and Hair loss

Hydroxycarbamide

Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. Dactinomycin and Hydroxycarbamide are World Health Organization essential medicines.

See Dactinomycin and Hydroxycarbamide

Intravenous therapy

Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.

See Dactinomycin and Intravenous therapy

Journal of Clinical Oncology

The Journal of Clinical Oncology is a peer-reviewed medical journal published 3 times a month by the Lippincott Williams & Wilkins.

See Dactinomycin and Journal of Clinical Oncology

Kynurenine pathway

The kynurenine pathway The kynurenine pathway is a metabolic pathway leading to the production of nicotinamide adenine dinucleotide (NAD+).

See Dactinomycin and Kynurenine pathway

Liver disease

Liver disease, or hepatic disease, is any of many diseases of the liver.

See Dactinomycin and Liver disease

Merck & Co.

Merck & Co., Inc. is an American multinational pharmaceutical company headquartered in Rahway, New Jersey, and is named for Merck Group, founded in Germany in 1668, of which it was once the American arm.

See Dactinomycin and Merck & Co.

Methyltransferase

Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features.

See Dactinomycin and Methyltransferase

Microscopy

Microscopy is the technical field of using microscopes to view objects and areas of objects that cannot be seen with the naked eye (objects that are not within the resolution range of the normal eye).

See Dactinomycin and Microscopy

Molar pregnancy

A molar pregnancy, also known as a hydatidiform mole, is an abnormal form of pregnancy in which a non-viable fertilized egg implants in the uterus.

See Dactinomycin and Molar pregnancy

Mouth ulcer

A mouth ulcer (aphtha) is an ulcer that occurs on the mucous membrane of the oral cavity.

See Dactinomycin and Mouth ulcer

Necrosis

Necrosis is a form of cell injury which results in the premature death of cells in living tissue by autolysis.

See Dactinomycin and Necrosis

Neoplasm

A neoplasm is a type of abnormal and excessive growth of tissue.

See Dactinomycin and Neoplasm

Ovarian cancer

Ovarian cancer is a cancerous tumor of an ovary.

See Dactinomycin and Ovarian cancer

Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).

See Dactinomycin and Pregnancy

Radiation therapy

Radiation therapy or radiotherapy (RT, RTx, or XRT) is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells.

See Dactinomycin and Radiation therapy

Radiosensitivity

Radiosensitivity is the relative susceptibility of cells, tissues, organs or organisms to the harmful effect of ionizing radiation.

See Dactinomycin and Radiosensitivity

Radiosensitizer

A radiosensitizer is an agent that makes tumor cells more sensitive to radiation therapy.

See Dactinomycin and Radiosensitizer

Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully differentiate into myocytes of skeletal muscle.

See Dactinomycin and Rhabdomyosarcoma

RNA

Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA).

See Dactinomycin and RNA

RNA polymerase

In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that catalyzes the chemical reactions that synthesize RNA from a DNA template.

See Dactinomycin and RNA polymerase

Selman Waksman

Selman Abraham Waksman (July 22, 1888 – August 16, 1973) was a Jewish Ukrainian inventor, Nobel Prize laureate, biochemist and microbiologist whose research into the decomposition of organisms that live in soil enabled the discovery of streptomycin and several other antibiotics.

See Dactinomycin and Selman Waksman

Sequence homology

Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.

See Dactinomycin and Sequence homology

Streptomyces

Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae.

See Dactinomycin and Streptomyces

Testicular cancer

Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.

See Dactinomycin and Testicular cancer

Transcription (biology)

Transcription is the process of copying a segment of DNA into RNA.

See Dactinomycin and Transcription (biology)

Trophoblastic neoplasm

Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus.

See Dactinomycin and Trophoblastic neoplasm

Tryptophan

Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins.

See Dactinomycin and Tryptophan

Tryptophan 2,3-dioxygenase

In enzymology, tryptophan 2,3-dioxygenase is a heme enzyme that catalyzes the oxidation of -tryptophan (-Trp) to L-kynurenine, as the first and rate-limiting step of the kynurenine pathway.

See Dactinomycin and Tryptophan 2,3-dioxygenase

Vincristine

Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. Dactinomycin and Vincristine are World Health Organization essential medicines.

See Dactinomycin and Vincristine

WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. Dactinomycin and WHO Model List of Essential Medicines are World Health Organization essential medicines.

See Dactinomycin and WHO Model List of Essential Medicines

Wilms' tumor

Wilms' tumor or Wilms tumor, also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children (rarely in adults), and occurs most commonly as a renal tumor in child patients.

See Dactinomycin and Wilms' tumor

7-Aminoactinomycin D

7-Aminoactinomycin D (7-AAD) is a fluorescent chemical compound with a strong affinity for DNA. Dactinomycin and 7-Aminoactinomycin D are DNA intercalaters.

See Dactinomycin and 7-Aminoactinomycin D

References

[1] https://en.wikipedia.org/wiki/Dactinomycin

Also known as ACT D, ACTINOMYCIN D, ACTO-D, ATC code L01DA01, ATCvet code QL01DA01, Actactinomycin a Iv, Actinomycin, Actinomycin 11 Cosmegen, Actinomycin 7, Actinomycin Aiv, Actinomycin C1, Actinomycin I, Actinomycin I1, Actinomycin Iv, Actinomycin X 1, Actinomycin-D, Actinomycine, C62H86N12O16, Chounghwamycin B, Cosmegen, HBF 386 Meractinomycin, Lyovac Cosmegen, Meractinomycin, Oncostatin K.

, Transcription (biology), Trophoblastic neoplasm, Tryptophan, Tryptophan 2,3-dioxygenase, Vincristine, WHO Model List of Essential Medicines, Wilms' tumor, 7-Aminoactinomycin D.

Dactinomycin, the Glossary

Table of Contents

See also

DNA intercalaters

DNA replication inhibitors

Depsipeptides

Polypeptide antibiotics

References