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Desipramine, the Glossary

Index Desipramine

Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression.[1]

Table of Contents

  1. 92 relations: Adrenergic receptor, Alpha-1 adrenergic receptor, Alpha-1 blocker, Alpha-2 adrenergic receptor, Amine, Amnesia, Anticholinergic, Antidepressant, Antihistamine, Argentina, Atomoxetine, Attention deficit hyperactivity disorder, Blurred vision, CAS Registry Number, Chemical formula, Chemical nomenclature, Chemical structure, Clomipramine, Cocaine dependence, Cognitive impairment, Constipation, CYP2D6, Depression (mood), Diário Oficial da União, Dibenzazepine, Dibudinic acid, Dopamine receptor D1, Dopamine receptor D2, Drug overdose, Feces, Free base, French language, Functional dyspepsia, German language, Histamine H1 receptor, Histamine H2 receptor, Histamine H3 receptor, Histamine H4 receptor, Hydrochloride, Imipramine, Insomnia, Intramuscular injection, Italian language, Latin, Liver, Lofepramine, Metabolite, Methylation, Molar mass, Muscarinic acetylcholine receptor M1, ... Expand index (42 more) »

  2. Antihistamines
  3. Dibenzazepines
  4. Norepinephrine reuptake inhibitors

Adrenergic receptor

The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2) agonists, which are used to treat high blood pressure and asthma, for example.

See Desipramine and Adrenergic receptor

Alpha-1 adrenergic receptor

alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein.

See Desipramine and Alpha-1 adrenergic receptor

Alpha-1 blocker

Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block the effect of catecholamines on alpha-1-adrenergic receptors. Desipramine and alpha-1 blocker are alpha-1 blockers.

See Desipramine and Alpha-1 blocker

Alpha-2 adrenergic receptor

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.

See Desipramine and Alpha-2 adrenergic receptor

Amine

In chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.

See Desipramine and Amine

Amnesia

Amnesia is a deficit in memory caused by brain damage or brain diseases,Gazzaniga, M., Ivry, R., & Mangun, G. (2009) Cognitive Neuroscience: The biology of the mind.

See Desipramine and Amnesia

Anticholinergic

Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central and peripheral nervous system.

See Desipramine and Anticholinergic

Antidepressant

Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.

See Desipramine and Antidepressant

Antihistamine

Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Desipramine and Antihistamine are Antihistamines.

See Desipramine and Antihistamine

Argentina

Argentina, officially the Argentine Republic, is a country in the southern half of South America.

See Desipramine and Argentina

Atomoxetine

Atomoxetine, sold under the brand name Strattera, is a selective norepinephrine reuptake inhibitor medication used to treat attention deficit hyperactivity disorder (ADHD) and, to a lesser extent, cognitive disengagement syndrome. Desipramine and Atomoxetine are secondary amines.

See Desipramine and Atomoxetine

Attention deficit hyperactivity disorder

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by executive dysfunction occasioning symptoms of inattention, hyperactivity, impulsivity and emotional dysregulation that are excessive and pervasive, impairing in multiple contexts, and otherwise age-inappropriate.

See Desipramine and Attention deficit hyperactivity disorder

Blurred vision

Blurred vision is an ocular symptom where vision becomes less precise and there is added difficulty to resolve fine details.

See Desipramine and Blurred vision

CAS Registry Number

A CAS Registry Number (also referred to as CAS RN or informally CAS Number) is a unique identification number, assigned by the Chemical Abstracts Service (CAS) in the US to every chemical substance described in the open scientific literature, in order to index the substance in the CAS Registry.

See Desipramine and CAS Registry Number

Chemical formula

A chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs.

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Chemical nomenclature

Chemical nomenclature is a set of rules to generate systematic names for chemical compounds.

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Chemical structure

A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds.

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Clomipramine

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). Desipramine and Clomipramine are alpha-1 blockers, Antihistamines, CYP2D6 inhibitors, Dibenzazepines, muscarinic antagonists, serotonin receptor antagonists and tricyclic antidepressants.

See Desipramine and Clomipramine

Cocaine dependence

Cocaine dependence is a neurological disorder that is characterized by withdrawal symptoms upon cessation from cocaine use.

See Desipramine and Cocaine dependence

Cognitive impairment

Cognitive impairment is an inclusive term to describe any characteristic that acts as a barrier to the cognition process or different areas of cognition.

See Desipramine and Cognitive impairment

Constipation

Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.

See Desipramine and Constipation

CYP2D6

Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.

See Desipramine and CYP2D6

Depression (mood)

Depression is a mental state of low mood and aversion to activity.

See Desipramine and Depression (mood)

Diário Oficial da União

The Diário Oficial da União (literally Official Diary of the Union), abbreviated DOU, is the official journal of the federal government of Brazil.

See Desipramine and Diário Oficial da União

Dibenzazepine

Dibenzazepine (iminostilbene) is a chemical compound with two benzene rings fused to an azepine ring. Desipramine and Dibenzazepine are Dibenzazepines and tricyclic antidepressants.

See Desipramine and Dibenzazepine

Dibudinic acid

Dibudinic acid, or dibudinate, is an organic compound.

See Desipramine and Dibudinic acid

Dopamine receptor D1

Dopamine receptor D1, also known as DRD1.

See Desipramine and Dopamine receptor D1

Dopamine receptor D2

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.

See Desipramine and Dopamine receptor D2

Drug overdose

A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended.

See Desipramine and Drug overdose

Feces

Feces (or faeces;: faex) are the solid or semi-solid remains of food that was not digested in the small intestine, and has been broken down by bacteria in the large intestine.

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Free base

Free base (freebase, free-base) is a descriptor for the neutral form of an amine commonly used in reference to illicit drugs.

See Desipramine and Free base

French language

French (français,, or langue française,, or by some speakers) is a Romance language of the Indo-European family.

See Desipramine and French language

Functional dyspepsia

Functional dyspepsia (FD) is a common gastrointestinal disorder defined by symptoms emanating from the gastroduodenal region in the absence of an underlying organic disease that may easily explain the symptoms.

See Desipramine and Functional dyspepsia

German language

German (Standard High German: Deutsch) is a West Germanic language in the Indo-European language family, mainly spoken in Western and Central Europe. It is the most widely spoken and official or co-official language in Germany, Austria, Switzerland, Liechtenstein, and the Italian province of South Tyrol.

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Histamine H1 receptor

The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.

See Desipramine and Histamine H1 receptor

Histamine H2 receptor

H2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals.

See Desipramine and Histamine H2 receptor

Histamine H3 receptor

Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons and control histamine turnover by feedback inhibition of histamine synthesis and release.

See Desipramine and Histamine H3 receptor

Histamine H4 receptor

The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the HRH4 gene.

See Desipramine and Histamine H4 receptor

Hydrochloride

In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).

See Desipramine and Hydrochloride

Imipramine

Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression. Desipramine and Imipramine are alpha-1 blockers, CYP2D6 inhibitors, Dibenzazepines, muscarinic antagonists, serotonin receptor antagonists and tricyclic antidepressants.

See Desipramine and Imipramine

Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

See Desipramine and Insomnia

Intramuscular injection

Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle.

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Italian language

Italian (italiano,, or lingua italiana) is a Romance language of the Indo-European language family that evolved from the Vulgar Latin of the Roman Empire.

See Desipramine and Italian language

Latin

Latin (lingua Latina,, or Latinum) is a classical language belonging to the Italic branch of the Indo-European languages.

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Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

See Desipramine and Liver

Lofepramine

Lofepramine, sold under the brand names Gamanil, Lomont, and Tymelyt among others, is a tricyclic antidepressant (TCA) which is used to treat depression. Desipramine and Lofepramine are alpha-1 blockers, Antihistamines, Dibenzazepines, muscarinic antagonists, norepinephrine reuptake inhibitors, serotonin receptor antagonists and tricyclic antidepressants.

See Desipramine and Lofepramine

In biochemistry, a metabolite is an intermediate or end product of metabolism.

See Desipramine and Metabolite

Methylation

Methylation, in the chemical sciences, is the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.

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Molar mass

In chemistry, the molar mass (or molecular weight) of a chemical compound is defined as the ratio between the mass and the amount of substance (measured in moles) of any sample of the compound.

See Desipramine and Molar mass

Muscarinic acetylcholine receptor M1

The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.

See Desipramine and Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M2

The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.

See Desipramine and Muscarinic acetylcholine receptor M2

Muscarinic acetylcholine receptor M3

The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.

See Desipramine and Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M4

The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.

See Desipramine and Muscarinic acetylcholine receptor M4

Muscarinic acetylcholine receptor M5

The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.

See Desipramine and Muscarinic acetylcholine receptor M5

N-type calcium channel

N-type calcium channels also called Cav2.2 channels are voltage gated calcium channels that are localized primarily on the nerve terminals and dendrites as well as neuroendocrine cells.

See Desipramine and N-type calcium channel

Neuropathic pain

Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system.

See Desipramine and Neuropathic pain

Neurotransmission

Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and react with the receptors on the dendrites of another neuron (the postsynaptic neuron) a short distance away.

See Desipramine and Neurotransmission

Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator.

See Desipramine and Norepinephrine

Norepinephrine reuptake inhibitor

A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET). Desipramine and norepinephrine reuptake inhibitor are norepinephrine reuptake inhibitors.

See Desipramine and Norepinephrine reuptake inhibitor

Norepinephrine transporter

The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.

See Desipramine and Norepinephrine transporter

Nortriptyline

Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. Desipramine and Nortriptyline are alpha-1 blockers, Antihistamines, human drug metabolites, muscarinic antagonists, secondary amines, serotonin receptor antagonists, Sodium channel blockers and tricyclic antidepressants.

See Desipramine and Nortriptyline

Novartis

Novartis AG is a Swiss multinational pharmaceutical corporation based in Basel, Switzerland.

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Oral administration

| name.

See Desipramine and Oral administration

Orthostatic hypotension

Orthostatic hypotension, also known as postural hypotension, is a medical condition wherein a person's blood pressure drops when standing up or sitting down.

See Desipramine and Orthostatic hypotension

Parent structure

In chemistry, a parent structure is the structure of an unadorned ion or molecule from which derivatives can be visualized.

See Desipramine and Parent structure

Pharmacodynamics

Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).

See Desipramine and Pharmacodynamics

Protriptyline

Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for the treatment of depression and attention-deficit hyperactivity disorder (ADHD). Desipramine and Protriptyline are alpha-1 blockers, Antihistamines, muscarinic antagonists, secondary amines, serotonin receptor antagonists and tricyclic antidepressants.

See Desipramine and Protriptyline

Ring (chemistry)

In chemistry, a ring is an ambiguous term referring either to a simple cycle of atoms and bonds in a molecule or to a connected set of atoms and bonds in which every atom and bond is a member of a cycle (also called a ring system).

See Desipramine and Ring (chemistry)

Salt (chemistry)

In chemistry, a salt or ionic compound is a chemical compound consisting of an assembly of positively charged ions (cations) and negatively charged ions (anions), which results in a compound with no net electric charge (electrically neutral).

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Sedation

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

See Desipramine and Sedation

Sedative

A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.

See Desipramine and Sedative

Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.

See Desipramine and Selective serotonin reuptake inhibitor

Serotonin reuptake inhibitor

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).

See Desipramine and Serotonin reuptake inhibitor

Side chain

In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called the "main chain" or backbone.

See Desipramine and Side chain

Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

See Desipramine and Side effect

Sigma-1 receptor

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.

See Desipramine and Sigma-1 receptor

Sigma-2 receptor

The sigma-2 receptor (σ2R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases such as neurological diseases, neurodegenerative, neuro-ophthalmic and cancer.

See Desipramine and Sigma-2 receptor

Spanish language

Spanish (español) or Castilian (castellano) is a Romance language of the Indo-European language family that evolved from the Vulgar Latin spoken on the Iberian Peninsula of Europe.

See Desipramine and Spanish language

Stimulant

Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase the activity of the brain. Desipramine and stimulant are stimulants.

See Desipramine and Stimulant

Trademark distinctiveness

Trademark distinctiveness is an important concept in the law governing trademarks and service marks.

See Desipramine and Trademark distinctiveness

Tricyclic

Tricyclics are cyclic chemical compounds that contain three fused rings of atoms.

See Desipramine and Tricyclic

Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. Desipramine and Tricyclic antidepressant are tricyclic antidepressants.

See Desipramine and Tricyclic antidepressant

Trimipramine

Trimipramine, sold under the brand name Surmontil among others, is a tricyclic antidepressant (TCA) which is used to treat depression. Desipramine and Trimipramine are alpha-1 blockers, Antihistamines, Dibenzazepines, muscarinic antagonists, serotonin receptor antagonists and tricyclic antidepressants.

See Desipramine and Trimipramine

Urinary retention

Urinary retention is an inability to completely empty the bladder.

See Desipramine and Urinary retention

Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

See Desipramine and Urine

Weight gain

Weight gain is an increase in body weight.

See Desipramine and Weight gain

Xerostomia

Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.

See Desipramine and Xerostomia

5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter.

See Desipramine and 5-HT1A receptor

5-HT2A receptor

The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

See Desipramine and 5-HT2A receptor

5-HT2C receptor

The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

See Desipramine and 5-HT2C receptor

5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors.

See Desipramine and 5-HT3 receptor

5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

See Desipramine and 5-HT7 receptor

See also

Antihistamines

Dibenzazepines

Norepinephrine reuptake inhibitors

References

[1] https://en.wikipedia.org/wiki/Desipramine

Also known as 2-Nitrodesmethylimipramine, ATC code N06AA01, ATCvet code QN06AA01, Demethylimipramine, Désipramin, Desipramina, Desipramine Hydrochloride, Desipramine dibudinate, Desipraminum, Desmethylimipramine, EX 4355, EX-4355, EX4355, G 35,020, G 35020, G-35,020, G-35020, G35,020, G35020, JB 8181, JB-8181, JB8181, N-Demethylimipramine, N-Desmethylimipramine, NSC 114,901, NSC 114901, NSC-114,901, NSC-114901, NSC114,901, NSC114901, Nebril, Norimipramine, Norpramin, Norpramine, Pentofran, Pertofran, Pertofrane, Pertrofane, Pertrofran, Pertrofrane, Petylyl, Sertofran.

, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, N-type calcium channel, Neuropathic pain, Neurotransmission, Norepinephrine, Norepinephrine reuptake inhibitor, Norepinephrine transporter, Nortriptyline, Novartis, Oral administration, Orthostatic hypotension, Parent structure, Pharmacodynamics, Protriptyline, Ring (chemistry), Salt (chemistry), Sedation, Sedative, Selective serotonin reuptake inhibitor, Serotonin reuptake inhibitor, Side chain, Side effect, Sigma-1 receptor, Sigma-2 receptor, Spanish language, Stimulant, Trademark distinctiveness, Tricyclic, Tricyclic antidepressant, Trimipramine, Urinary retention, Urine, Weight gain, Xerostomia, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT7 receptor.