Edelfosine, the Glossary
Edelfosine (ET-18-O-CH3; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine) is a synthetic alkyl-lysophospholipid (ALP).[1]
Table of Contents
19 relations: Alkyl-lysophospholipids, Apoptosis, Bone marrow, Breast cancer, Cell membrane, Chemotherapy, Cisplatin, DNA, Fas receptor, HIV, Leukemia, Lysophosphatidylcholine, Macrophage, MAPK/ERK pathway, Miltefosine, Multiple myeloma, Non-small-cell lung cancer, Perifosine, Protein kinase B.
- Phospholipids
- Zwitterions
Alkyl-lysophospholipids
Alky-lysophospholipids (ALPs) are synthetic analogs of lysophosphatidylcholines (LPCs), also called lysolecithins.
See Edelfosine and Alkyl-lysophospholipids
Apoptosis
Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.
Bone marrow
Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones.
See Edelfosine and Bone marrow
Breast cancer
Breast cancer is a cancer that develops from breast tissue.
See Edelfosine and Breast cancer
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
See Edelfosine and Cell membrane
Chemotherapy
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.
See Edelfosine and Chemotherapy
Cisplatin
Cisplatin is a chemical compound with formula cis-.
DNA
Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.
Fas receptor
The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene.
See Edelfosine and Fas receptor
HIV
The human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans.
Leukemia
Leukemia (also spelled leukaemia; pronounced) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells.
Lysophosphatidylcholine
Lysophosphatidylcholines (LPC, lysoPC), also called lysolecithins, are a class of chemical compounds which are derived from phosphatidylcholines.
See Edelfosine and Lysophosphatidylcholine
Macrophage
Macrophages (abbreviated Mφ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface.
MAPK/ERK pathway
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
See Edelfosine and MAPK/ERK pathway
Miltefosine
Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and free-living amoeba infections such as Naegleria fowleri and Balamuthia mandrillaris. Edelfosine and Miltefosine are Quaternary ammonium compounds.
See Edelfosine and Miltefosine
Multiple myeloma
Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies.
See Edelfosine and Multiple myeloma
Non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC).
See Edelfosine and Non-small-cell lung cancer
Perifosine
Perifosine (also KRX-0401) is a former drug candidate that was under development for a variety of cancer indications. Edelfosine and Perifosine are Phospholipids, Quaternary ammonium compounds and Zwitterions.
Protein kinase B
Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.
See Edelfosine and Protein kinase B
See also
Phospholipids
- 1,2-Dioleoyl-sn-glycerophosphoethanolamine
- 1-Lysophosphatidylcholine
- Alkylglycerol monooxygenase
- Cardiolipin
- Dinogunellin
- Dipalmitoylphosphatidylcholine
- Dolichol monophosphate
- Dolichyl beta-D-glucosyl phosphate
- Edelfosine
- Egg lecithin
- Endothelial lipase
- Ethanol-induced non-lamellar phases in phospholipids
- Fostriecin
- Glycerophospholipid
- Hydroxylated lecithin
- Lecithin
- Lysobisphosphatidic acid
- Lysophosphatidic acid
- Lysophosphatidylethanolamine
- Lysophosphatidylinositol
- Monolysocardiolipin
- Myo-Inositol trispyrophosphate
- PIP2 (disambiguation)
- POPC
- Perifosine
- Phosphatidylcholine
- Phosphatidylcholines
- Phosphatidylethanol
- Phosphatidylethanolamine
- Phosphatidylethanolamines
- Phosphatidylglycerol
- Phosphatidylinositol
- Phosphatidylinositol (3,4,5)-trisphosphate
- Phosphatidylinositol 3,4-bisphosphate
- Phosphatidylinositol 3,5-bisphosphate
- Phosphatidylinositol 3-phosphate
- Phosphatidylinositol 4,5-bisphosphate
- Phosphatidylinositol 4-phosphate
- Phosphatidylinositol 5-phosphate
- Phosphatidylinositol phosphate
- Phosphatidylinositol-4-phosphate 5-kinase
- Phosphatidylmyo-inositol mannosides
- Phosphatidylserine
- Phospholipid
- Phosphorylcholine
- Phytosome
- Plasmalogen
- Sphingomyelin
- Sphingosyl phosphatide
Zwitterions
- 2-Hydroxy-3-morpholinopropanesulfonic acid
- 3-Dehydrocarnitine
- ADA (buffer)
- Amino acid
- Arsenobetaine
- Betaine
- Bicine
- Burgess reagent
- Ceftazidime
- Cephaloridine
- Cylindrospermopsin
- D-Amino acid
- Dimethylsulfoniopropionate
- Diphthamide
- Edelfosine
- Fosmanogepix
- HEPBS
- Hydrogen isocyanide
- Isoionic point
- MSPI (nerve agent)
- Meldonium
- Mesoionic compounds
- Perifosine
- Phosphocholine
- Plakohypaphorine
- Polysulfobetaine
- Quinonoid zwitterion
- Sucrononic acid
- Tetrodotoxin
- Tricine
- Trigonelline
- Trimethylglycine
- Zwitterion