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Efocipegtrutide, the Glossary

Efocipegtrutide (HM15211) is a triple agonist of the glucagon, GIP, and glucagon-like peptide 1 receptors.^[1]

Gastric inhibitory polypeptide receptor

The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.

See Efocipegtrutide and Gastric inhibitory polypeptide receptor

Glucagon receptor

The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in the activation of adenylate cyclase and phospholipase C and in increased levels of the secondary messengers intracellular cAMP and calcium.

See Efocipegtrutide and Glucagon receptor

Glucagon-like peptide-1 receptor

The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain.

See Efocipegtrutide and Glucagon-like peptide-1 receptor

Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a type of chronic liver disease.

See Efocipegtrutide and Metabolic dysfunction–associated steatotic liver disease

References

[1] https://en.wikipedia.org/wiki/Efocipegtrutide

Also known as HM15211.

Efocipegtrutide, the Glossary

Table of Contents

Gastric inhibitory polypeptide receptor

Glucagon receptor

Glucagon-like peptide-1 receptor

See also

GIP receptor agonists

GLP-1 receptor agonists

Glucagon receptor agonists

References