Entacapone, the Glossary
Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.[1]
Table of Contents
85 relations: Adjuvant therapy, Adrenaline, Adverse effect, Albumin, Alcoholism, Allergy, Altered state of consciousness, Apomorphine, Aromatic L-amino acid decarboxylase inhibitor, Bile duct, Binding selectivity, Bioavailability, Biological half-life, Blood plasma, Blood–brain barrier, Brain, Breast milk, Carbidopa, Carbidopa/levodopa, Carbidopa/levodopa/entacapone, Catechol, Catechol-O-methyltransferase, Catechol-O-methyltransferase inhibitor, Catecholamine, Chelation, Cmax (pharmacology), Confidence interval, CYP2C9, Dehydration, Delirium, Delusion, Diarrhea, Diazepam, Diário Oficial da União, Distribution (pharmacology), Dobutamine, Dopamine, Dyskinesia, E–Z notation, Enzyme, Enzyme inhibitor, European Medicines Agency, Excretion, First pass effect, Glucuronide, Human serum albumin, Hydroxylation, Ibuprofen, Infant, Intravenous therapy, ... Expand index (35 more) »
- Catechol-O-methyltransferase inhibitors
- Nitrophenol derivatives
Adjuvant therapy
Adjuvant therapy, also known as adjunct therapy, adjuvant care, or augmentation therapy, is a therapy that is given in addition to the primary or initial therapy to maximize its effectiveness.
See Entacapone and Adjuvant therapy
Adrenaline
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration).
Adverse effect
An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery.
See Entacapone and Adverse effect
Albumin
Albumin is a family of globular proteins, the most common of which are the serum albumins.
Alcoholism
Alcoholism is the continued drinking of alcohol despite it causing problems.
Allergy
Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.
Altered state of consciousness
An altered state of consciousness (ASC), also called an altered state of mind, altered mental status (AMS) or mind alteration, is any condition which is significantly different from a normal waking state.
See Entacapone and Altered state of consciousness
Apomorphine
Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. Entacapone and Apomorphine are catechols.
See Entacapone and Apomorphine
Aromatic L-amino acid decarboxylase inhibitor
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, Extracerebral decarboxylase inhibitor, DDCI and AAADI) is a medication of type enzyme inhibitor which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AADC, AAAD, or DOPA decarboxylase).
See Entacapone and Aromatic L-amino acid decarboxylase inhibitor
Bile duct
A bile duct is any of a number of long tube-like structures that carry bile, and is present in most vertebrates.
Binding selectivity
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
See Entacapone and Binding selectivity
Bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.
See Entacapone and Bioavailability
Biological half-life
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.
See Entacapone and Biological half-life
Blood plasma
Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.
See Entacapone and Blood plasma
Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.
See Entacapone and Blood–brain barrier
Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
Breast milk
Breast milk (sometimes spelled as breastmilk) or mother's milk is milk produced by the mammary glands in the breast of human females.
See Entacapone and Breast milk
Carbidopa
Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa. Entacapone and Carbidopa are Peripherally selective drugs.
Carbidopa/levodopa
Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa.
See Entacapone and Carbidopa/levodopa
Carbidopa/levodopa/entacapone
Carbidopa/levodopa/entacapone, sold under the brand name Stalevo among others, is a dopaminergic fixed-dose combination medication that contains carbidopa, levodopa, and entacapone for the treatment of Parkinson's disease.
See Entacapone and Carbidopa/levodopa/entacapone
Catechol
Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula. Entacapone and Catechol are catechols.
Catechol-O-methyltransferase
Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.
See Entacapone and Catechol-O-methyltransferase
Catechol-O-methyltransferase inhibitor
A catechol-O-methyltransferase (COMT) inhibitor is a drug that inhibits the enzyme catechol-''O''-methyltransferase. Entacapone and catechol-O-methyltransferase inhibitor are catechol-O-methyltransferase inhibitors and Peripherally selective drugs.
See Entacapone and Catechol-O-methyltransferase inhibitor
Catecholamine
A catecholamine (abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine.
See Entacapone and Catecholamine
Chelation
Chelation is a type of bonding of ions and the molecules to metal ions.
Cmax (pharmacology)
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose.
See Entacapone and Cmax (pharmacology)
Confidence interval
Informally, in frequentist statistics, a confidence interval (CI) is an interval which is expected to typically contain the parameter being estimated.
See Entacapone and Confidence interval
CYP2C9
Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein.
Dehydration
In physiology, dehydration is a lack of total body water, with an accompanying disruption of metabolic processes.
See Entacapone and Dehydration
Delirium
Delirium (formerly acute confusional state, an ambiguous term which is now discouraged) is a specific state of acute confusion attributable to the direct physiological consequence of a medical condition, effects of a psychoactive substance, or multiple causes, which usually develops over the course of hours to days.
Delusion
A delusion is a false fixed belief that is not amenable to change in light of conflicting evidence.
Diarrhea
Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day.
Diazepam
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic.
Diário Oficial da União
The Diário Oficial da União (literally Official Diary of the Union), abbreviated DOU, is the official journal of the federal government of Brazil.
See Entacapone and Diário Oficial da União
Distribution (pharmacology)
Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.
See Entacapone and Distribution (pharmacology)
Dobutamine
Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure.
Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. Entacapone and Dopamine are Peripherally selective drugs.
Dyskinesia
Dyskinesia refers to a category of movement disorders that are characterized by involuntary muscle movements, including movements similar to tics or chorea and diminished voluntary movements.
E–Z notation
E–Z configuration, or the E–Z convention, is the IUPAC preferred method of describing the absolute stereochemistry of double bonds in organic chemistry.
See Entacapone and E–Z notation
Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.
See Entacapone and Enzyme inhibitor
European Medicines Agency
The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.
See Entacapone and European Medicines Agency
Excretion
Excretion is elimination of metabolic waste, which is an essential process in all organisms.
First pass effect
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
See Entacapone and First pass effect
Glucuronide
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.
See Entacapone and Glucuronide
Human serum albumin
Human serum albumin is the serum albumin found in human blood.
See Entacapone and Human serum albumin
Hydroxylation
In chemistry, hydroxylation can refer to.
See Entacapone and Hydroxylation
Ibuprofen
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation.
Infant
An infant or baby is the very young offspring of human beings.
Intravenous therapy
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.
See Entacapone and Intravenous therapy
Isoprenaline
Isoprenaline, or isoproterenol, is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. Entacapone and Isoprenaline are Peripherally selective drugs.
See Entacapone and Isoprenaline
L-DOPA
-DOPA, also known as levodopa and -3,4-dihydroxyphenylalanine, is made and used as part of the normal biology of some plants and animals, including humans.
Levodopa-induced dyskinesia
Levodopa-induced dyskinesia (LID) is a form of dyskinesia associated with levodopa (l-DOPA), used to treat Parkinson's disease.
See Entacapone and Levodopa-induced dyskinesia
Lipophilicity
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly") is the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
See Entacapone and Lipophilicity
Liver
The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.
Liver disease
Liver disease, or hepatic disease, is any of many diseases of the liver.
See Entacapone and Liver disease
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.
In biochemistry, a metabolite is an intermediate or end product of metabolism.
Methyldopa
Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure.
Monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
See Entacapone and Monoamine oxidase inhibitor
Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator. Entacapone and Norepinephrine are Peripherally selective drugs.
See Entacapone and Norepinephrine
Norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).
See Entacapone and Norepinephrine reuptake inhibitor
Novartis
Novartis AG is a Swiss multinational pharmaceutical corporation based in Basel, Switzerland.
Oral administration
| name.
See Entacapone and Oral administration
Orion Corporation (Finnish company)
Orion Corporation (Orion Oyj), founded in 1917 and headquartered at Espoo, Finland, is a globally operating Finnish company which develops, manufactures and markets human and veterinary pharmaceuticals and active pharmaceutical ingredients for global markets.
See Entacapone and Orion Corporation (Finnish company)
Orthostatic hypotension
Orthostatic hypotension, also known as postural hypotension, is a medical condition wherein a person's blood pressure drops when standing up or sitting down.
See Entacapone and Orthostatic hypotension
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.
See Entacapone and Parkinson's disease
Peripheral vascular system
The peripheral vascular system is the part of the circulatory system that consists of the veins and arteries not in the chest or abdomen (i.e. in the arms, hands, legs and feet).
See Entacapone and Peripheral vascular system
Peripherally selective drug
Peripherally selective drugs have their primary mechanism of action outside of the central nervous system (CNS), usually because they are excluded from the CNS by the blood–brain barrier. Entacapone and Peripherally selective drug are Peripherally selective drugs.
See Entacapone and Peripherally selective drug
Placebo
A placebo is a substance or treatment which is designed to have no therapeutic value.
Postmarketing surveillance
Postmarketing surveillance (PMS), also known as post market surveillance, is the practice of monitoring the safety of a pharmaceutical drug or medical device after it has been released on the market and is an important part of the science of pharmacovigilance.
See Entacapone and Postmarketing surveillance
Potassium
Potassium is a chemical element; it has symbol K (from Neo-Latin kalium) and atomic number19.
Pregnancy
Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).
Pregnancy category
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy.
See Entacapone and Pregnancy category
Prothrombin time
The prothrombin time (PT) – along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) – is an assay for evaluating the extrinsic pathway and common pathway of coagulation.
See Entacapone and Prothrombin time
Restless legs syndrome
Restless legs syndrome, also known as restless leg syndrome (RLS), also known as Willis–Ekbom disease (WED), is a neurological disorder, usually chronic, that causes an overwhelming urge to move one's legs.
See Entacapone and Restless legs syndrome
Signs and symptoms of Parkinson's disease
Signs and symptoms of Parkinson's disease are varied.
See Entacapone and Signs and symptoms of Parkinson's disease
Sleep onset
Sleep onset is the transition from wakefulness into sleep.
See Entacapone and Sleep onset
Somnolence
Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
Surgery
Surgery is a medical specialty that uses manual and instrumental techniques to diagnose or treat pathological conditions (e.g., trauma, disease, injury, malignancy), to alter bodily functions (i.e., malabsorption created by bariatric surgery such as gastric bypass), to reconstruct or improve aesthetics and appearance (cosmetic surgery), or to remove unwanted tissues (body fat, glands, scars or skin tags) or foreign bodies.
Tissue (biology)
In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function.
See Entacapone and Tissue (biology)
Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
See Entacapone and Tricyclic antidepressant
Volume of distribution
In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, volume of dilution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.
See Entacapone and Volume of distribution
Warfarin
Warfarin is an anticoagulant used as a medication under several brand names including Coumadin.
3-O-Methyldopa
3-O-Methyldopa (3-OMD) is one of the most important metabolites of L-DOPA, a drug used in the treatment of the Parkinson's disease.
See Entacapone and 3-O-Methyldopa
See also
Catechol-O-methyltransferase inhibitors
- 2-Hydroxyestradiol
- 2-Hydroxyestrone
- Catechol estrogen
- Catechol-O-methyltransferase inhibitor
- Entacapone
- Nitecapone
- Opicapone
- Quinalizarin
- Tolcapone
Nitrophenol derivatives
- 3-Amino-5-nitrosalicylic acid
- 5-Nitrovanillin
- Dinitro-ortho-cresol
- Entacapone
- Mordant brown 33
- Nitecapone
- Nitroapocynin
- Opicapone
- Roxarsone
- TFM (piscicide)
- Tolcapone
References
[1] https://en.wikipedia.org/wiki/Entacapone
Also known as ATC code N04BX02, ATCvet code QN04BX02, C14H15N3O5, COMTan, Comtess.
, Isoprenaline, L-DOPA, Levodopa-induced dyskinesia, Lipophilicity, Liver, Liver disease, Metabolism, Metabolite, Methyldopa, Monoamine oxidase inhibitor, Norepinephrine, Norepinephrine reuptake inhibitor, Novartis, Oral administration, Orion Corporation (Finnish company), Orthostatic hypotension, Parkinson's disease, Peripheral vascular system, Peripherally selective drug, Placebo, Postmarketing surveillance, Potassium, Pregnancy, Pregnancy category, Prothrombin time, Restless legs syndrome, Signs and symptoms of Parkinson's disease, Sleep onset, Somnolence, Surgery, Tissue (biology), Tricyclic antidepressant, Volume of distribution, Warfarin, 3-O-Methyldopa.