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Eslicarbazepine acetate, the Glossary

Eslicarbazepine acetate (ESL), sold under the brand names Aptiom and Zebinix among others, is an anticonvulsant medication approved for use in Europe and the United States as monotherapy or as additional therapy for partial-onset seizures epilepsy.^[1]

55 relations: Acetic acid, Acute generalized exanthematous pustulosis, Anticonvulsant, Antidote, Atrioventricular block, Bial, Biological half-life, Bipolar disorder, Blood plasma, Carbamazepine, CYP2C19, CYP3A4, Diarrhea, Diplopia, Drug rash with eosinophilia and systemic symptoms, Eisai (company), Epilepsy, Ester, Ethinylestradiol, European Medicines Agency, Food and Drug Administration, Gastrointestinal tract, Glucuronidation, Glucuronide, Glucuronosyltransferase, Health Canada, Hemiparesis, Hemodialysis, HLA-A, HLA-B, Human leukocyte antigen, Hyponatremia, Lamotrigine, Levetiracetam, Levonorgestrel, Licarbazepine, Mechanism of action, Oral administration, Oxcarbazepine, Phenytoin, Plasma protein binding, Prodrug, Racemic mixture, Rash, Simvastatin, Sodium, Somnolence, Stereoisomerism, Stevens–Johnson syndrome, Suicidal ideation, ... Expand index (5 more) »
Dibenzazepines
Portuguese inventions

Acetic acid

Acetic acid, systematically named ethanoic acid, is an acidic, colourless liquid and organic compound with the chemical formula (also written as,, or). Vinegar is at least 4% acetic acid by volume, making acetic acid the main component of vinegar apart from water.

See Eslicarbazepine acetate and Acetic acid

Acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic pustuloderma) is a rare skin reaction that in 90% of cases is related to medication.

See Eslicarbazepine acetate and Acute generalized exanthematous pustulosis

Anticonvulsant

Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Eslicarbazepine acetate and Anticonvulsant are anticonvulsants.

See Eslicarbazepine acetate and Anticonvulsant

Antidote

An antidote is a substance that can counteract a form of poisoning.

See Eslicarbazepine acetate and Antidote

Atrioventricular block

Atrioventricular block (AV block) is a type of heart block that occurs when the electrical signal traveling from the atria, or the upper chambers of the heart, to ventricles, or the lower chambers of the heart, is impaired.

See Eslicarbazepine acetate and Atrioventricular block

Bial

Bial (Portela e C.ª, S.A.) is a pharmaceutical company headquartered in São Mamede do Coronado, in Trofa, Porto district, Portugal.

See Eslicarbazepine acetate and Bial

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Eslicarbazepine acetate and Biological half-life

Bipolar disorder

Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that each last from days to weeks.

See Eslicarbazepine acetate and Bipolar disorder

Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.

See Eslicarbazepine acetate and Blood plasma

Carbamazepine

Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain. Eslicarbazepine acetate and Carbamazepine are anticonvulsants, CYP3A4 inducers, Dibenzazepines and Ureas.

See Eslicarbazepine acetate and Carbamazepine

CYP2C19

Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein.

See Eslicarbazepine acetate and CYP2C19

CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene.

See Eslicarbazepine acetate and CYP3A4

Diarrhea

Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day.

See Eslicarbazepine acetate and Diarrhea

Diplopia

Diplopia is the simultaneous perception of two images of a single object that may be displaced horizontally or vertically in relation to each other.

See Eslicarbazepine acetate and Diplopia

Drug rash with eosinophilia and systemic symptoms

Drug rash with eosinophilia and systemic symptoms or drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications.

See Eslicarbazepine acetate and Drug rash with eosinophilia and systemic symptoms

Eisai (company)

is a Japanese pharmaceutical company headquartered in Tokyo, Japan.

See Eslicarbazepine acetate and Eisai (company)

Epilepsy

Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures.

See Eslicarbazepine acetate and Epilepsy

Ester

In chemistry, an ester is a functional group derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group of that acid is replaced by an organyl group.

See Eslicarbazepine acetate and Ester

Ethinylestradiol

Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins.

See Eslicarbazepine acetate and Ethinylestradiol

European Medicines Agency

The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.

See Eslicarbazepine acetate and European Medicines Agency

Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

See Eslicarbazepine acetate and Food and Drug Administration

Gastrointestinal tract

The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.

See Eslicarbazepine acetate and Gastrointestinal tract

Glucuronidation

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

See Eslicarbazepine acetate and Glucuronidation

Glucuronide

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.

See Eslicarbazepine acetate and Glucuronide

Glucuronosyltransferase

Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule.

See Eslicarbazepine acetate and Glucuronosyltransferase

Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

See Eslicarbazepine acetate and Health Canada

Hemiparesis

Hemiparesis, also called unilateral paresis, is the weakness of one entire side of the body (hemi- means "half").

See Eslicarbazepine acetate and Hemiparesis

Hemodialysis

Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of filtering the blood of a person whose kidneys are not working normally.

See Eslicarbazepine acetate and Hemodialysis

HLA-A

HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3.

See Eslicarbazepine acetate and HLA-A

HLA-B

HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system.

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Human leukocyte antigen

The human leukocyte antigen (HLA) system or complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system.

See Eslicarbazepine acetate and Human leukocyte antigen

Hyponatremia

Hyponatremia or hyponatraemia is a low concentration of sodium in the blood.

See Eslicarbazepine acetate and Hyponatremia

Lamotrigine

Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. Eslicarbazepine acetate and Lamotrigine are anticonvulsants.

See Eslicarbazepine acetate and Lamotrigine

Levetiracetam

Levetiracetam, sold under the brand name Keppra among others, is a medication used to treat epilepsy. Eslicarbazepine acetate and Levetiracetam are anticonvulsants and Enantiopure drugs.

See Eslicarbazepine acetate and Levetiracetam

Levonorgestrel

Levonorgestrel is a hormonal medication which is used in a number of birth control methods. Eslicarbazepine acetate and Levonorgestrel are Enantiopure drugs.

See Eslicarbazepine acetate and Levonorgestrel

Licarbazepine

Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. Eslicarbazepine acetate and Licarbazepine are anticonvulsants, Dibenzazepines and Ureas.

See Eslicarbazepine acetate and Licarbazepine

Mechanism of action

In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.

See Eslicarbazepine acetate and Mechanism of action

Oral administration

| name.

See Eslicarbazepine acetate and Oral administration

Oxcarbazepine

Oxcarbazepine, sold under the brand name Trileptal among others, is a medication used to treat epilepsy. For epilepsy it is used for both focal seizures and generalized seizures. It has been used both alone and as add-on therapy in people with bipolar disorder who have had no success with other treatments. Eslicarbazepine acetate and Oxcarbazepine are anticonvulsants, CYP3A4 inducers, Dibenzazepines and Ureas.

See Eslicarbazepine acetate and Oxcarbazepine

Phenytoin

Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. Eslicarbazepine acetate and Phenytoin are anticonvulsants and CYP3A4 inducers.

See Eslicarbazepine acetate and Phenytoin

Plasma protein binding

Plasma protein binding refers to the degree to which medications attach to blood proteins within the blood plasma.

See Eslicarbazepine acetate and Plasma protein binding

Prodrug

A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

See Eslicarbazepine acetate and Prodrug

Racemic mixture

In chemistry, a racemic mixture or racemate is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt.

See Eslicarbazepine acetate and Racemic mixture

Rash

A rash is a change of the skin that affects its color, appearance, or texture.

See Eslicarbazepine acetate and Rash

Simvastatin

Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication.

See Eslicarbazepine acetate and Simvastatin

Sodium

Sodium is a chemical element; it has symbol Na (from Neo-Latin natrium) and atomic number 11.

See Eslicarbazepine acetate and Sodium

Somnolence

Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

See Eslicarbazepine acetate and Somnolence

Stereoisomerism

In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.

See Eslicarbazepine acetate and Stereoisomerism

Stevens–Johnson syndrome

Stevens–Johnson syndrome (SJS) is a type of severe skin reaction.

See Eslicarbazepine acetate and Stevens–Johnson syndrome

Suicidal ideation

Suicidal ideation, or suicidal thoughts, is the thought process of having ideas, or ruminations about the possibility of completing suicide.

See Eslicarbazepine acetate and Suicidal ideation

Sunovion

On July 1, 2023, Sunovion Pharmaceuticals Inc. became part of Sumitomo Pharma America, Inc., a biopharmaceutical company focused on delivering therapeutic and scientific breakthroughs in areas of critical patient need spanning psychiatry and neurology, oncology, urology, women's health, rare disease, and cell and gene therapies.

See Eslicarbazepine acetate and Sunovion

Topiramate

Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. Eslicarbazepine acetate and Topiramate are anticonvulsants and CYP3A4 inducers.

See Eslicarbazepine acetate and Topiramate

Trigeminal neuralgia

Trigeminal neuralgia (TN or TGN), also called Fothergill disease, tic douloureux, trifacial neuralgia, or suicide disease, is a long-term pain disorder that affects the trigeminal nerve, the nerve responsible for sensation in the face and motor functions such as biting and chewing.

See Eslicarbazepine acetate and Trigeminal neuralgia

Valproate

Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. Eslicarbazepine acetate and valproate are anticonvulsants.

See Eslicarbazepine acetate and Valproate

Voltage-gated sodium channel

Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na+.

See Eslicarbazepine acetate and Voltage-gated sodium channel

References

[1] https://en.wikipedia.org/wiki/Eslicarbazepine_acetate

Also known as ATC code N03AF04, ATCvet code QN03AF04, Aptiom, C17H16N2O3, Eslicarbazepine, Exalief, Stedesa, Zebinix.

, Sunovion, Topiramate, Trigeminal neuralgia, Valproate, Voltage-gated sodium channel.

Eslicarbazepine acetate, the Glossary

Table of Contents

See also

Dibenzazepines

Portuguese inventions

References