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Exon junction complex, the Glossary

Index Exon junction complex

An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing.[1]

Table of Contents

  1. 51 relations: Adenosine triphosphate, ALYREF, Amino acid, Arginine, Asparagine, ATPase, BAT1, Beta sheet, CDKN2B, Chromatin, Coactivator (genetics), Crystallization, Cytoplasm, DEAD box, DEK (gene), EIF4A3, Eukaryote, Eukaryotic translation termination factor 1, Exon, GSPT1, Helicase, Initiation factor, MAGOH, Messenger RNA, MRNA surveillance, N6-Methyladenosine, Nonsense mutation, Nonsense-mediated decay, Nuclear pore, Nucleoprotein, Nucleotide, NXF1, NXT1, Phosphorylation, PI3K/AKT/mTOR pathway, Primary transcript, Protein, Protein complex, RBM8A, Ribosome, RNA, RNA splicing, RNPS1, Salt bridge (protein and supramolecular), SMG1, SRRM1, Stop codon, Translation (biology), UPF1, UPF2, ... Expand index (1 more) »

Adenosine triphosphate

Adenosine triphosphate (ATP) is a nucleotide that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis.

See Exon junction complex and Adenosine triphosphate

ALYREF

Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene.

See Exon junction complex and ALYREF

Amino acid

Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.

See Exon junction complex and Amino acid

Arginine

Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H.

See Exon junction complex and Arginine

Asparagine

Asparagine (symbol Asn or N) is an α-amino acid that is used in the biosynthesis of proteins.

See Exon junction complex and Asparagine

ATPase

ATPases (Adenosine 5'-TriPhosphatase, adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion or the inverse reaction.

See Exon junction complex and ATPase

BAT1

Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene.

See Exon junction complex and BAT1

Beta sheet

The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure.

See Exon junction complex and Beta sheet

CDKN2B

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans.

See Exon junction complex and CDKN2B

Chromatin

Chromatin is a complex of DNA and protein found in eukaryotic cells.

See Exon junction complex and Chromatin

Coactivator (genetics)

A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.

See Exon junction complex and Coactivator (genetics)

Crystallization

Crystallization is the process by which solids form, where the atoms or molecules are highly organized into a structure known as a crystal.

See Exon junction complex and Crystallization

Cytoplasm

In cell biology, the cytoplasm describes all material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus.

See Exon junction complex and Cytoplasm

DEAD box

DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids.

See Exon junction complex and DEAD box

DEK (gene)

The human DEK gene encodes the DEK protein.

See Exon junction complex and DEK (gene)

EIF4A3

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

See Exon junction complex and EIF4A3

Eukaryote

The eukaryotes constitute the domain of Eukarya or Eukaryota, organisms whose cells have a membrane-bound nucleus.

See Exon junction complex and Eukaryote

Eukaryotic translation termination factor 1

Eukaryotic translation termination factor 1 (eRF1), also referred to as TB3-1 or SUP45L1, is a protein that is encoded by the ERF1 gene.

See Exon junction complex and Eukaryotic translation termination factor 1

Exon

An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. Exon junction complex and exon are Spliceosome.

See Exon junction complex and Exon

GSPT1

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.

See Exon junction complex and GSPT1

Helicase

Helicases are a class of enzymes thought to be vital to all organisms.

See Exon junction complex and Helicase

Initiation factor

In molecular biology, initiation factors are proteins that bind to the small subunit of the ribosome during the initiation of translation, a part of protein biosynthesis.

See Exon junction complex and Initiation factor

MAGOH

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene.

See Exon junction complex and MAGOH

Messenger RNA

In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. Exon junction complex and messenger RNA are RNA and Spliceosome.

See Exon junction complex and Messenger RNA

MRNA surveillance

mRNA surveillance mechanisms are pathways utilized by organisms to ensure fidelity and quality of messenger RNA (mRNA) molecules. Exon junction complex and MRNA surveillance are RNA.

See Exon junction complex and MRNA surveillance

N6-Methyladenosine

N6-Methyladenosine (m6A) was originally identified and partially characterised in the 1970s, and is an abundant modification in mRNA and DNA.

See Exon junction complex and N6-Methyladenosine

Nonsense mutation

In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a nonsense codon, or a premature stop codon in the transcribed mRNA, and leads to a truncated, incomplete, and possibly nonfunctional protein product.

See Exon junction complex and Nonsense mutation

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes.

See Exon junction complex and Nonsense-mediated decay

Nuclear pore

A nuclear pore is a channel as part of the nuclear pore complex (NPC), a large protein complex found in the nuclear envelope of eukaryotic cells.

See Exon junction complex and Nuclear pore

Nucleoprotein

Nucleoproteins are proteins conjugated with nucleic acids (either DNA or RNA).

See Exon junction complex and Nucleoprotein

Nucleotide

Nucleotides are organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate.

See Exon junction complex and Nucleotide

NXF1

Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the NXF1 gene.

See Exon junction complex and NXF1

NXT1

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

See Exon junction complex and NXT1

Phosphorylation

In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion.

See Exon junction complex and Phosphorylation

PI3K/AKT/mTOR pathway

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.

See Exon junction complex and PI3K/AKT/mTOR pathway

Primary transcript

A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. Exon junction complex and primary transcript are RNA.

See Exon junction complex and Primary transcript

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

See Exon junction complex and Protein

Protein complex

A protein complex or multiprotein complex is a group of two or more associated polypeptide chains.

See Exon junction complex and Protein complex

RBM8A

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene.

See Exon junction complex and RBM8A

Ribosome

Ribosomes are macromolecular machines, found within all cells, that perform biological protein synthesis (messenger RNA translation).

See Exon junction complex and Ribosome

RNA

Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA).

See Exon junction complex and RNA

RNA splicing

RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA). Exon junction complex and RNA splicing are RNA and Spliceosome.

See Exon junction complex and RNA splicing

RNPS1

RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.

See Exon junction complex and RNPS1

Salt bridge (protein and supramolecular)

In chemistry, a salt bridge is a combination of two non-covalent interactions: hydrogen bonding and ionic bonding (Figure 1).

See Exon junction complex and Salt bridge (protein and supramolecular)

SMG1

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.

See Exon junction complex and SMG1

SRRM1

Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.

See Exon junction complex and SRRM1

Stop codon

In molecular biology, a stop codon (or termination codon) is a codon (nucleotide triplet within messenger RNA) that signals the termination of the translation process of the current protein.

See Exon junction complex and Stop codon

Translation (biology)

In biology, translation is the process in living cells in which proteins are produced using RNA molecules as templates.

See Exon junction complex and Translation (biology)

UPF1

Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene.

See Exon junction complex and UPF1

UPF2

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.

See Exon junction complex and UPF2

UPF3B

Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.

See Exon junction complex and UPF3B

References

[1] https://en.wikipedia.org/wiki/Exon_junction_complex

, UPF3B.