Fibronectin, the Glossary
Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.[1]
Table of Contents
116 relations: Alternative splicing, Amphibian, Androgen receptor, Animal embryonic development, Apoptosis, Arginylglycylaspartic acid, Basement membrane, Beta-sandwich, Biological target, Biomarker, Blood plasma, Blood vessel, C-terminus, Carcinogen, Carcinoma, CD44, CD93, Cell (biology), Cell adhesion, Cell culture, Cell cycle, Cell growth, Cell membrane, Cell migration, Cellular differentiation, Chemotherapy, Collagen, Collagen, type VII, alpha 1, Colonisation (biology), Concentration, Cyclin D, Dalton (unit), Disseminated intravascular coagulation, Disulfide, Drug resistance, Embryo, Extracellular matrix, Factor XIII, FBLN1, Fetal fibronectin, Fibril, Fibrin, Fibroblast, Fibronectin type I domain, Fibronectin type II domain, Fibronectin type III domain, Fibrosis, Force, Gastrulation, Gene, ... Expand index (66 more) »
- Diagnostic obstetrics and gynaecology
Alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to produce different splice variants.
See Fibronectin and Alternative splicing
Amphibian
Amphibians are ectothermic, anamniotic, four-limbed vertebrate animals that constitute the class Amphibia.
Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus.
See Fibronectin and Androgen receptor
Animal embryonic development
In developmental biology, animal embryonic development, also known as animal embryogenesis, is the developmental stage of an animal embryo.
See Fibronectin and Animal embryonic development
Apoptosis
Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.
Arginylglycylaspartic acid
Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.
See Fibronectin and Arginylglycylaspartic acid
Basement membrane
The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling.
See Fibronectin and Basement membrane
Beta-sandwich
Beta-sandwich or β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins.
See Fibronectin and Beta-sandwich
Biological target
A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.
See Fibronectin and Biological target
Biomarker
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition.
Blood plasma
Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.
See Fibronectin and Blood plasma
Blood vessel
Blood vessels are the structures of the circulatory system that transport blood throughout the human body.
See Fibronectin and Blood vessel
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
See Fibronectin and C-terminus
Carcinogen
A carcinogen is any agent that promotes the development of cancer.
See Fibronectin and Carcinogen
Carcinoma
Carcinoma is a malignancy that develops from epithelial cells.
CD44
The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. Fibronectin and CD44 are glycoproteins.
CD93
CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene.
Cell (biology)
The cell is the basic structural and functional unit of all forms of life.
See Fibronectin and Cell (biology)
Cell adhesion
Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface.
See Fibronectin and Cell adhesion
Cell culture
Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment.
See Fibronectin and Cell culture
Cell cycle
The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell that causes it to divide into two daughter cells.
See Fibronectin and Cell cycle
Cell growth
Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume.
See Fibronectin and Cell growth
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
See Fibronectin and Cell membrane
Cell migration
Cell migration is a central process in the development and maintenance of multicellular organisms.
See Fibronectin and Cell migration
Cellular differentiation
Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one.
See Fibronectin and Cellular differentiation
Chemotherapy
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.
See Fibronectin and Chemotherapy
Collagen
Collagen is the main structural protein in the extracellular matrix of a body's various connective tissues.
Collagen, type VII, alpha 1
Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene.
See Fibronectin and Collagen, type VII, alpha 1
Colonisation (biology)
Colonisation or colonization is the spread and development of an organism in a new area or habitat.
See Fibronectin and Colonisation (biology)
Concentration
In chemistry, concentration is the abundance of a constituent divided by the total volume of a mixture.
See Fibronectin and Concentration
Cyclin D
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression.
Dalton (unit)
The dalton or unified atomic mass unit (symbols: Da or u) is a non-SI unit of mass defined as of the mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state and at rest.
See Fibronectin and Dalton (unit)
Disseminated intravascular coagulation
Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels.
See Fibronectin and Disseminated intravascular coagulation
Disulfide
In chemistry, a disulfide (or disulphide in British English) is a compound containing a functional group or the anion.
Drug resistance
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition.
See Fibronectin and Drug resistance
Embryo
An embryo is the initial stage of development for a multicellular organism.
In biology, the extracellular matrix (ECM), also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
See Fibronectin and Extracellular matrix
Factor XIII
Factor XIII, or fibrin stabilizing factor, is a plasma protein and zymogen.
See Fibronectin and Factor XIII
FBLN1
FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.
Fetal fibronectin
Fetal fibronectin (fFN) is a fibronectin protein produced by fetal cells.
See Fibronectin and Fetal fibronectin
Fibril
Fibrils (from the Latin fibra) are structural biological materials found in nearly all living organisms.
Fibrin
Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.
Fibroblast
A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.
See Fibronectin and Fibroblast
Fibronectin type I domain
Fibronectin, type I repeats are one of the three repeats found in the fibronectin protein.
See Fibronectin and Fibronectin type I domain
Fibronectin type II domain
Fibronectin type II domain is a collagen-binding protein domain.
See Fibronectin and Fibronectin type II domain
Fibronectin type III domain
The Fibronectin type III domain is an evolutionarily conserved protein domain that is widely found in animal proteins.
See Fibronectin and Fibronectin type III domain
Fibrosis
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue.
Force
A force is an influence that can cause an object to change its velocity, i.e., to accelerate, meaning a change in speed or direction, unless counterbalanced by other forces.
Gastrulation
Gastrulation is the stage in the early embryonic development of most animals, during which the blastula (a single-layered hollow sphere of cells), or in mammals the blastocyst, is reorganized into a two-layered or three-layered embryo known as the gastrula.
See Fibronectin and Gastrulation
Gene
In biology, the word gene has two meanings.
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype.
See Fibronectin and Gene expression
Gene knockout
Gene knockouts (also known as gene deletion or gene inactivation) are a widely used genetic engineering technique that involves the targeted removal or inactivation of a specific gene within an organism's genome.
See Fibronectin and Gene knockout
Glycoprotein
Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains. Fibronectin and Glycoprotein are glycoproteins.
See Fibronectin and Glycoprotein
Glycosaminoglycan
Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units).
See Fibronectin and Glycosaminoglycan
Granulation tissue
Granulation tissue is new connective tissue and microscopic blood vessels that form on the surfaces of a wound during the healing process.
See Fibronectin and Granulation tissue
Heparan sulfate
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues.
See Fibronectin and Heparan sulfate
Heparin
Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan.
Hepatocyte
A hepatocyte is a cell of the main parenchymal tissue of the liver.
See Fibronectin and Hepatocyte
Histology
Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissues.
IGFBP3
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene.
Immortalised cell line
An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.
See Fibronectin and Immortalised cell line
Integrin
Integrins are transmembrane receptors that help cell-cell and cell-extracellular matrix (ECM) adhesion.
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See Fibronectin and Ligand (biochemistry)
Lipoprotein(a)
Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a).
See Fibronectin and Lipoprotein(a)
Liver
The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.
Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung.
See Fibronectin and Lung cancer
Macromolecule
A macromolecule is a very large molecule important to biological processes, such as a protein or nucleic acid.
See Fibronectin and Macromolecule
Macrophage
Macrophages (abbreviated Mφ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface.
See Fibronectin and Macrophage
Mammal
A mammal is a vertebrate animal of the class Mammalia.
Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins.
See Fibronectin and Matrix metalloproteinase
Mesoderm
The mesoderm is the middle layer of the three germ layers that develops during gastrulation in the very early development of the embryo of most animals.
Molar mass
In chemistry, the molar mass (or molecular weight) of a chemical compound is defined as the ratio between the mass and the amount of substance (measured in moles) of any sample of the compound.
See Fibronectin and Molar mass
Monobody
Monobodies are synthetic binding proteins constructed using a fibronectin type III domain (FN3) as a molecular scaffold.
Monomer
A monomer (mono-, "one" + -mer, "part") is a molecule that can react together with other monomer molecules to form a larger polymer chain or three-dimensional network in a process called polymerization.
Mouth
The mouth is the body orifice through which many animals ingest food and vocalize.
N-Ethylmaleimide
N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid.
See Fibronectin and N-Ethylmaleimide
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide.
See Fibronectin and N-terminus
Neoplasm
A neoplasm is a type of abnormal and excessive growth of tissue.
Neural tube
In the developing chordate (including vertebrates), the neural tube is the embryonic precursor to the central nervous system, which is made up of the brain and spinal cord.
See Fibronectin and Neural tube
Non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC).
See Fibronectin and Non-small-cell lung cancer
Oligomer
In chemistry and biochemistry, an oligomer is a molecule that consists of a few repeating units which could be derived, actually or conceptually, from smaller molecules, monomers.
Organ (biology)
In a multicellular organism, an organ is a collection of tissues joined in a structural unit to serve a common function.
See Fibronectin and Organ (biology)
Pathogenic bacteria
Pathogenic bacteria are bacteria that can cause disease.
See Fibronectin and Pathogenic bacteria
Pathology
Pathology is the study of disease and injury.
Peptide
Peptides are short chains of amino acids linked by peptide bonds.
Phagocytosis
Phagocytosis is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome.
See Fibronectin and Phagocytosis
Pharynx
The pharynx (pharynges) is the part of the throat behind the mouth and nasal cavity, and above the esophagus and trachea (the tubes going down to the stomach and the lungs respectively).
Primary transcript
A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs.
See Fibronectin and Primary transcript
Protease
A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products.
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
Protein dimer
In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound.
See Fibronectin and Protein dimer
Protein domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest.
See Fibronectin and Protein domain
Protein isoform
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
See Fibronectin and Protein isoform
Protein subunit
In structural biology, a protein subunit is a polypeptide chain or single protein molecule that assembles (or "coassembles") with others to form a protein complex.
See Fibronectin and Protein subunit
Protein–protein interaction
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.
See Fibronectin and Protein–protein interaction
Proteoglycan
Proteoglycans are proteins that are heavily glycosylated. Fibronectin and Proteoglycan are glycoproteins.
See Fibronectin and Proteoglycan
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
See Fibronectin and Proteolysis
Protomer
In structural biology, a protomer is the structural unit of an oligomeric protein.
Radioresistance
Radioresistance is the level of ionizing radiation that organisms are able to withstand.
See Fibronectin and Radioresistance
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
See Fibronectin and Receptor (biochemistry)
Reticular fiber
Reticular fibers, reticular fibres or reticulin is a type of fiber in connective tissue composed of type III collagen secreted by reticular cells.
See Fibronectin and Reticular fiber
RNA splicing
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA).
See Fibronectin and RNA splicing
Secretion
Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland.
Sex hormone
Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors.
See Fibronectin and Sex hormone
Solubility
In chemistry, solubility is the ability of a substance, the solute, to form a solution with another substance, the solvent.
See Fibronectin and Solubility
Substrate adhesion molecules
Substrate adhesion molecules (SAMs) are proteins that attach cells to specific compounds in the extracellular matrix (a process known as cell adhesion).
See Fibronectin and Substrate adhesion molecules
Syndecan
Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors.
Tenascin
Tenascins are extracellular matrix glycoproteins.
Tenascin C
Tenascin C (TN-C) is a glycoprotein that in humans is encoded by the TNC gene.
See Fibronectin and Tenascin C
Thiol
In organic chemistry, a thiol, or thiol derivative, is any organosulfur compound of the form, where R represents an alkyl or other organic substituent.
Thrombus
A thrombus (thrombi), colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.
Tissue (biology)
In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function.
See Fibronectin and Tissue (biology)
TRIB3
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.
Trypsin
Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces.
Vertebrate
Vertebrates are deuterostomal animals with bony or cartilaginous axial endoskeleton — known as the vertebral column, spine or backbone — around and along the spinal cord, including all fish, amphibians, reptiles, birds and mammals.
See Fibronectin and Vertebrate
Wound healing
Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue.
See Fibronectin and Wound healing
See also
Diagnostic obstetrics and gynaecology
- Apgar score
- BI-RADS
- Bishop score
- Breast cancer screening
- Breast duct endoscopy
- Breast imaging
- Breast self-examination
- Breast ultrasound
- Cervical conization
- Chromopertubation
- Colposcopy
- Curettage
- Cytopathology
- Defecography
- Ductoscopy
- Dynamic angiothermography
- Endoscopic ultrasound
- Fibronectin
- Gynecologic ultrasonography
- Gynography
- Gynoroentgenology
- Hystero contrast sonography
- Hysteroscopy
- Liquid-based cytology
- Nottingham Prognostic Index
- Pap test
- Partogram
- Pinard horn
- SEE-FIM Protocol
- Sonosalpingography
- Triple test score
- Vaginal cytology
- Vaginal ultrasonography
References
[1] https://en.wikipedia.org/wiki/Fibronectin
Also known as Cold-insoluble globulin, FN1, FN1 (gene), Fibronectin 1, Fibronectins.
, Gene expression, Gene knockout, Glycoprotein, Glycosaminoglycan, Granulation tissue, Heparan sulfate, Heparin, Hepatocyte, Histology, IGFBP3, Immortalised cell line, Integrin, Ligand (biochemistry), Lipoprotein(a), Liver, Lung cancer, Macromolecule, Macrophage, Mammal, Matrix metalloproteinase, Mesoderm, Molar mass, Monobody, Monomer, Mouth, N-Ethylmaleimide, N-terminus, Neoplasm, Neural tube, Non-small-cell lung cancer, Oligomer, Organ (biology), Pathogenic bacteria, Pathology, Peptide, Phagocytosis, Pharynx, Primary transcript, Protease, Protein, Protein dimer, Protein domain, Protein isoform, Protein subunit, Protein–protein interaction, Proteoglycan, Proteolysis, Protomer, Radioresistance, Receptor (biochemistry), Reticular fiber, RNA splicing, Secretion, Sex hormone, Solubility, Substrate adhesion molecules, Syndecan, Tenascin, Tenascin C, Thiol, Thrombus, Tissue (biology), TRIB3, Trypsin, Vertebrate, Wound healing.