JAG1, the Glossary
Jagged1 (JAG1) is one of five cell surface proteins (ligands) that interact with four receptors in the mammalian Notch signaling pathway.[1]
Table of Contents
55 relations: Adrenocortical carcinoma, Alagille syndrome, Amino acid, Beverly Torok-Storb, Branchial arch, Breast cancer, Cell nucleus, Children's Hospital of Philadelphia, Chromosome 20, Circulatory system, Cluster of differentiation, Conditional gene knockout, Dominance (genetics), Drosophila, EGF-like domain, Endothelium, Exon, Eye, Glossary of biology, Haploinsufficiency, Heart, In situ hybridization, Kidney, Kidney development, Ligand (biochemistry), Liver, Lung, Mesenchyme, Missense mutation, Molecular cloning, Mutation, National Institutes of Health, Nonsense, Notch 2, Notch signaling pathway, Otic vesicle, Pancreas, Phenotype, Placenta, Portal vein, Prostate, Proteolysis, Pulmonary artery, Pulmonic stenosis, Receptor (biochemistry), Ribosomal frameshift, RNA splicing, Signal peptide, Skeleton, Testicle, ... Expand index (5 more) »
Adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland.
See JAG1 and Adrenocortical carcinoma
Alagille syndrome
Alagille syndrome (ALGS) is a genetic disorder that affects primarily the liver and the heart.
See JAG1 and Alagille syndrome
Amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.
Beverly Torok-Storb
Beverly Jo Torok-Storb (1948 – May 5, 2023) was an American physician who was Professor of Clinical Research at the Fred Hutchinson Cancer Research Center.
See JAG1 and Beverly Torok-Storb
Branchial arch
Branchial arches, or gill arches, are a series of paired bony "loops" that support the gills in fish.
Breast cancer
Breast cancer is a cancer that develops from breast tissue.
Cell nucleus
The cell nucleus (nuclei) is a membrane-bound organelle found in eukaryotic cells.
Children's Hospital of Philadelphia
The Children's Hospital of Philadelphia, also known by its acronym CHOP, is a children's hospital in Philadelphia, Pennsylvania.
See JAG1 and Children's Hospital of Philadelphia
Chromosome 20
Chromosome 20 is one of the 23 pairs of chromosomes in humans. JAG1 and chromosome 20 are genes on human chromosome 20.
Circulatory system
The circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate.
See JAG1 and Circulatory system
Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. JAG1 and cluster of differentiation are clusters of differentiation.
See JAG1 and Cluster of differentiation
Conditional gene knockout
Conditional gene knockout is a technique used to eliminate a specific gene in a certain tissue, such as the liver.
See JAG1 and Conditional gene knockout
Dominance (genetics)
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome.
See JAG1 and Dominance (genetics)
Drosophila
Drosophila is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.
EGF-like domain
The EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described.
Endothelium
The endothelium (endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels.
Exon
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
See JAG1 and Exon
Eye
An eye is a sensory organ that allows an organism to perceive visual information.
See JAG1 and Eye
Glossary of biology
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms.
See JAG1 and Glossary of biology
Haploinsufficiency
Haploinsufficiency in genetics describes a model of dominant gene action in diploid organisms, in which a single copy of the wild-type allele at a locus in heterozygous combination with a variant allele is insufficient to produce the wild-type phenotype.
See JAG1 and Haploinsufficiency
Heart
The heart is a muscular organ found in most animals.
See JAG1 and Heart
In situ hybridization
In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA, RNA or modified nucleic acid strand (i.e., a probe) to localize a specific DNA or RNA sequence in a portion or section of tissue (in situ) or if the tissue is small enough (e.g., plant seeds, Drosophila embryos), in the entire tissue (whole mount ISH), in cells, and in circulating tumor cells (CTCs).
See JAG1 and In situ hybridization
Kidney
In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.
See JAG1 and Kidney
Kidney development
Kidney development, or nephrogenesis, describes the embryologic origins of the kidney, a major organ in the urinary system.
See JAG1 and Kidney development
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See JAG1 and Ligand (biochemistry)
Liver
The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.
See JAG1 and Liver
Lung
The lungs are the central organs of the respiratory system in humans and some other animals, including tetrapods, some snails and a small number of fish.
See JAG1 and Lung
Mesenchyme
Mesenchyme is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone.
Missense mutation
In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.
See JAG1 and Missense mutation
Molecular cloning
Molecular cloning is a set of experimental methods in molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms.
See JAG1 and Molecular cloning
Mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA.
National Institutes of Health
The National Institutes of Health, commonly referred to as NIH, is the primary agency of the United States government responsible for biomedical and public health research.
See JAG1 and National Institutes of Health
Nonsense
Nonsense is a form of communication, via speech, writing, or any other symbolic system, that lacks any coherent meaning.
Notch 2
Neurogenic locus notch homolog protein 2 (Notch 2) is a protein that in humans is encoded by the NOTCH2 gene.
See JAG1 and Notch 2
Notch signaling pathway
The Notch signaling pathway is a highly conserved cell signaling system present in most animals.
See JAG1 and Notch signaling pathway
Otic vesicle
Otic vesicle, or auditory vesicle, consists of either of the two sac-like invaginations formed and subsequently closed off during embryonic development.
Pancreas
The pancreas is an organ of the digestive system and endocrine system of vertebrates.
Phenotype
In genetics, the phenotype is the set of observable characteristics or traits of an organism.
Placenta
The placenta (placentas or placentae) is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation.
Portal vein
The portal vein or hepatic portal vein (HPV) is a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver.
Prostate
The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation.
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
Pulmonary artery
A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs.
Pulmonic stenosis
Pulmonic stenosis, is a dynamic or fixed obstruction of flow from the right ventricle of the heart to the pulmonary artery.
See JAG1 and Pulmonic stenosis
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
See JAG1 and Receptor (biochemistry)
Ribosomal frameshift
Ribosomal frameshifting, also known as translational frameshifting or translational recoding, is a biological phenomenon that occurs during translation that results in the production of multiple, unique proteins from a single mRNA.
See JAG1 and Ribosomal frameshift
RNA splicing
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA).
Signal peptide
A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) present at the N-terminus (or occasionally nonclassically at the C-terminus or internally) of most newly synthesized proteins that are destined toward the secretory pathway.
Skeleton
A skeleton is the structural frame that supports the body of most animals.
Testicle
A testicle or testis (testes) is the male gonad in all bilaterians, including humans.
Tetralogy of Fallot
Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects.
See JAG1 and Tetralogy of Fallot
Thymus
The thymus (thymuses or thymi) is a specialized primary lymphoid organ of the immune system.
See JAG1 and Thymus
Transmembrane protein
A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane.
See JAG1 and Transmembrane protein
White blood cell
White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
Zygosity
Zygosity (the noun, zygote, is from the Greek "yoked," from "yoke") is the degree to which both copies of a chromosome or gene have the same genetic sequence.
References
[1] https://en.wikipedia.org/wiki/JAG1
Also known as CD339, JAG1 (gene), JAGL1, Jagged (ligand), Jagged 1, Jagged-1 protein, Jagged1.
, Tetralogy of Fallot, Thymus, Transmembrane protein, White blood cell, Zygosity.