en.unionpedia.org

JQ1, the Glossary

Index JQ1

JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals.[1]

Table of Contents

  1. 17 relations: Acute lymphoblastic leukemia, Acute myeloid leukemia, Benzodiazepine, BET inhibitor, BRD2, BRD4, BRDT, Bromodomain, Bromodomain-containing protein 3, CDD-2807, HIV, Male contraceptive, Multiple myeloma, NUT carcinoma, TDI-11861, Thienotriazolodiazepine, YCT529.

  2. Contraception for males
  3. Thienotriazolodiazepines

Acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.

See JQ1 and Acute lymphoblastic leukemia

Acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production.

See JQ1 and Acute myeloid leukemia

Benzodiazepine

Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

See JQ1 and Benzodiazepine

BET inhibitor

BET inhibitors are a class of drugs that reversibly bind the bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT, and prevent protein-protein interaction between BET proteins and acetylated histones and transcription factors.

See JQ1 and BET inhibitor

BRD2

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene.

See JQ1 and BRD2

BRD4

Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene.

See JQ1 and BRD4

BRDT

Bromodomain testis-specific protein is a protein that in humans is encoded by the BRDT gene.

See JQ1 and BRDT

Bromodomain

A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones.

See JQ1 and Bromodomain

Bromodomain-containing protein 3

Bromodomain-containing protein 3 (BRD3) also known as RING3-like protein (RING3L) is a protein that in humans is encoded by the BRD3 gene.

See JQ1 and Bromodomain-containing protein 3

CDD-2807

CDD-2807 is a chemical compound which acts as a potent and selective inhibitor of serine/threonine-protein kinase 33 (STK33), with a IC50 of 9.2 nM.

See JQ1 and CDD-2807

HIV

The human immunodeficiency viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans.

See JQ1 and HIV

Male contraceptive

Male contraceptives, also known as male birth control, are methods of preventing pregnancy by interrupting the function of sperm. JQ1 and male contraceptive are Contraception for males.

See JQ1 and Male contraceptive

Multiple myeloma

Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies.

See JQ1 and Multiple myeloma

NUT carcinoma

NUT carcinoma (NC; formerly NUT midline carcinoma (NMC)) is a rare genetically defined, very aggressive squamous cell epithelial cancer that usually arises in the midline of the body and is characterized by a chromosomal rearrangement in the nuclear protein in testis gene (i.e. NUTM1 gene).

See JQ1 and NUT carcinoma

TDI-11861

TDI-11861 is a chemical compound which acts as a potent and selective inhibitor of soluble adenylyl cyclase (sAC).

See JQ1 and TDI-11861

Thienotriazolodiazepine

A thienotriazolodiazepine is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. JQ1 and thienotriazolodiazepine are thienotriazolodiazepines.

See JQ1 and Thienotriazolodiazepine

YCT529

YCT529 is a drug which acts as a potent and selective antagonist of the Vitamin A receptor retinoic acid receptor alpha (RAR-α). JQ1 and YCT529 are Contraception for males.

See JQ1 and YCT529

See also

Contraception for males

Thienotriazolodiazepines

References

[1] https://en.wikipedia.org/wiki/JQ1

Also known as C23H25ClN4O2S.