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Modified vaccinia Ankara, the Glossary

Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus.^[1]

38 relations: Ankara, Antigen, Antonio Siccardi, Bavarian Nordic, Cancer, Centers for Disease Control and Prevention, Emergency Use Authorization, European Medicines Agency, Fibroblast, Flavivirus, Food and Drug Administration, Gene, Gene expression, Genetic recombination, Health Canada, HIV/AIDS, Human parainfluenza viruses, Influenza, Intradermal injection, Measles, Mpox, MVA-B, MVA85A, National Institute of Allergy and Infectious Diseases, Orthopoxvirus, Plasmodium, Poxviridae, Reporter gene, Serial passage, Smallpox, Smallpox vaccine, Subcutaneous administration, Transgene, Vaccine, Vaccinia, Vectors in gene therapy, Viral vector vaccine, Volker Erfle.
1968 establishments in West Germany
1968 in medicine
Products introduced in 1968
Vaccinia

Ankara

Ankara, historically known as Ancyra and Angora, is the capital of Turkey. Located in the central part of Anatolia, the city has a population of 5.1 million in its urban center and 5.8 million in Ankara Province, making it Turkey's second-largest city after Istanbul, but first by the urban area (4,130 km2).

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Antigen

In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor.

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Antonio Siccardi

Antonio G. Siccardi (born 1 October 1944, Varese) is an Italian immunologist and virologist.

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Bavarian Nordic

Bavarian Nordic A/S is a fully integrated biotechnology company focused on the development, manufacturing and commercialization of vaccines.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Centers for Disease Control and Prevention

The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States.

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An Emergency Use Authorization (EUA) in the United States is an authorization granted to the Food and Drug Administration (FDA) under sections of the Federal Food, Drug, and Cosmetic Act as added to and amended by various Acts of Congress, including by the Pandemic and All-Hazards Preparedness Reauthorization Act of 2013 (PAHPRA), as codified by, to allow the use of a drug prior to approval.

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European Medicines Agency

The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.

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Fibroblast

A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.

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Flavivirus

Flavivirus, renamed Orthoflavivirus in 2023, is a genus of positive-strand RNA viruses in the family Flaviviridae.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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Gene

In biology, the word gene has two meanings.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype.

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Genetic recombination

Genetic recombination (also known as genetic reshuffling) is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits that differ from those found in either parent.

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Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

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HIV/AIDS

The human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system.

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Human parainfluenza viruses

Human parainfluenza viruses (HPIVs) are the viruses that cause human parainfluenza.

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Influenza

Influenza, commonly known as "the flu" or just "flu", is an infectious disease caused by influenza viruses.

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Intradermal injection

Intradermal injection (also intracutaneous or intradermic, abbreviated as ID) is a shallow or superficial injection of a substance into the dermis, which is located between the epidermis and the hypodermis.

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Measles

Measles is a highly contagious, vaccine-preventable infectious disease caused by measles virus.

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Mpox

Mpox (formerly known as monkeypox) is an infectious viral disease that can occur in humans and other animals.

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MVA-B

MVA-B, or Modified Vaccinia Ankara B, is an HIV vaccine created to give immune resistance to infection by the human immunodeficiency virus. Modified vaccinia Ankara and MVA-B are Genetically modified organisms.

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MVA85A

MVA85A (modified vaccinia Ankara 85A) is a vaccine against tuberculosis developed by researchers led by Professor Helen McShane at Oxford University.

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National Institute of Allergy and Infectious Diseases

The National Institute of Allergy and Infectious Diseases (NIAID) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS).

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Orthopoxvirus

Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae.

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Plasmodium

Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects.

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Poxviridae

Poxviridae is a family of double-stranded DNA viruses.

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Reporter gene

In molecular biology, a reporter gene (often simply reporter) is a gene that researchers attach to a regulatory sequence of another gene of interest in bacteria, cell culture, animals or plants.

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Serial passage

Serial passage is the process of growing bacteria or a virus in iterations.

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Smallpox

Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus.

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Smallpox vaccine

The smallpox vaccine is the first vaccine to have been developed against a contagious disease. Modified vaccinia Ankara and smallpox vaccine are vaccinia.

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Subcutaneous administration

Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion.

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Transgene

A transgene is a gene that has been transferred naturally, or by any of a number of genetic engineering techniques, from one organism to another.

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Vaccine

A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. Modified vaccinia Ankara and vaccine are vaccines.

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Vaccinia

Vaccinia virus (VACV or VV) is a large, complex, enveloped virus belonging to the poxvirus family. Modified vaccinia Ankara and Vaccinia are vaccines.

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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below.

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Viral vector vaccine

A viral vector vaccine is a vaccine that uses a viral vector to deliver genetic material (DNA) that can be transcribed by the recipient's host cells as mRNA coding for a desired protein, or antigen, to elicit an immune response.

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Volker Erfle

Volker Fritz Erfle (* February 26, 1941; † May 13, 2023) was a German virologist and university lecturer.

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References

[1] https://en.wikipedia.org/wiki/Modified_vaccinia_Ankara

Also known as Modified Vaccinia Ankara Virus, Non-replicating smallpox vaccine.

Modified vaccinia Ankara, the Glossary

Table of Contents

See also

1968 establishments in West Germany

1968 in medicine

Products introduced in 1968

Vaccinia

References