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Obeticholic acid, the Glossary

Obeticholic acid (OCA), sold under the brand name Ocaliva, is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid.^[1]

36 relations: Alkaline phosphatase, Bile acid, Bile acid malabsorption, Bile duct, Biomarker, Chenodeoxycholic acid, Cholestasis, Cirrhosis, Committee for Medicinal Products for Human Use, Crohn's disease, European Medicines Agency, Farnesoid X receptor, Fatty liver disease, FGF19, Fibrosis, Food and Drug Administration, Health Canada, Histology, Ileum, Inflammation, Intercept Pharmaceuticals, Itch, Jaundice, Ligand, Liver transplantation, Medication, Metabolic dysfunction–associated steatotic liver disease, National Institute of Diabetes and Digestive and Kidney Diseases, Oral administration, Orphan drug, Portal hypertension, Primary biliary cholangitis, Semisynthesis, Sumitomo Pharma, University of Perugia, Ursodeoxycholic acid.
Bile acids
Cholanes
Experimental drugs developed for non-alcoholic fatty liver disease
Farnesoid X receptor agonists

Alkaline phosphatase

The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds.

See Obeticholic acid and Alkaline phosphatase

Bile acid

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Obeticholic acid and bile acid are bile acids and farnesoid X receptor agonists.

See Obeticholic acid and Bile acid

Bile acid malabsorption

Bile acid malabsorption (BAM), known also as bile acid diarrhea, is a cause of several gut-related problems, the main one being chronic diarrhea.

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Bile duct

A bile duct is any of a number of long tube-like structures that carry bile, and is present in most vertebrates.

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Biomarker

In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition.

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Chenodeoxycholic acid (CDCA; also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. Obeticholic acid and Chenodeoxycholic acid are bile acids, Cholanes, Diols and farnesoid X receptor agonists.

See Obeticholic acid and Chenodeoxycholic acid

Cholestasis

Cholestasis is a condition where the flow of bile from the liver to the duodenum is impaired.

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Cirrhosis

Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is a condition of the liver in which the normal functioning tissue, or parenchyma, is replaced with scar tissue (fibrosis) and regenerative nodules as a result of chronic liver disease.

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Committee for Medicinal Products for Human Use

The Committee for Medicinal Products for Human Use (CHMP), formerly known as the Committee for Proprietary Medicinal Products (CPMP), is the European Medicines Agency's committee responsible for elaborating the agency's opinions on all issues regarding medicinal products for human use.

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Crohn's disease

Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract.

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European Medicines Agency

The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.

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Farnesoid X receptor

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is encoded by the NR1H4 gene in humans.

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Fatty liver disease

Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver.

See Obeticholic acid and Fatty liver disease

FGF19

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene.

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Fibrosis

Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

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Histology

Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissues.

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Ileum

The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds.

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Inflammation

Inflammation (from inflammatio) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.

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Intercept Pharmaceuticals

Intercept Pharmaceuticals, Inc. is an American biopharmaceutical company incorporated in 2002, focusing on the development of novel synthetic bile acid analogs to treat chronic liver diseases, such as primary biliary cirrhosis (PBC) now called primary biliary cholangitis, non-alcoholic fatty liver disease (or non-alcoholic steatohepatitis, NASH), cirrhosis, portal hypertension, primary sclerosing cholangitis and also the intestinal disorder, bile acid diarrhea.

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Itch

An itch (also known as pruritus) is a sensation that causes a strong desire or reflex to scratch.

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Jaundice

Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels.

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Ligand

In coordination chemistry, a ligand is an ion or molecule with a functional group that binds to a central metal atom to form a coordination complex.

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Liver transplantation

Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft).

See Obeticholic acid and Liver transplantation

Medication

A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a type of chronic liver disease.

See Obeticholic acid and Metabolic dysfunction–associated steatotic liver disease

National Institute of Diabetes and Digestive and Kidney Diseases

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is part of the United States National Institutes of Health, which in turn is part of the Department of Health and Human Services.

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Oral administration

| name.

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Orphan drug

An orphan drug is a pharmaceutical agent that is developed to treat certain rare medical conditions. Obeticholic acid and orphan drug are orphan drugs.

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Portal hypertension

Portal hypertension is defined as increased portal venous pressure, with a hepatic venous pressure gradient greater than 5 mmHg.

See Obeticholic acid and Portal hypertension

Primary biliary cholangitis

Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver.

See Obeticholic acid and Primary biliary cholangitis

Semisynthesis

Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds with distinct chemical and medicinal properties.

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Sumitomo Pharma

is a Japanese multinational pharmaceutical company.

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University of Perugia

The University of Perugia (Italian Università degli Studi di Perugia) is a public university in Perugia, Italy.

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Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria. Obeticholic acid and Ursodeoxycholic acid are bile acids, Cholanes, drugs acting on the gastrointestinal system and metabolism and orphan drugs.

See Obeticholic acid and Ursodeoxycholic acid

References

[1] https://en.wikipedia.org/wiki/Obeticholic_acid

Also known as Ocaliva.

Obeticholic acid, the Glossary

Table of Contents

See also

Bile acids

Cholanes

Experimental drugs developed for non-alcoholic fatty liver disease

Farnesoid X receptor agonists

References