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Oxycodone, the Glossary

Index Oxycodone

Oxycodone, sold under various brand names such as Roxicodone and OxyContin (which is the extended release form), is a semi-synthetic opioid used medically for treatment of moderate to severe pain.[1]

Table of Contents

  1. 264 relations: Abdominal pain, Addiction, Adolf Hitler, Agonist, Alberta, Analgesic, Annual Reviews (publisher), Anorexia (symptom), Anterograde amnesia, Anxiety, Anxiolytic, Apnea, Area under the curve (pharmacokinetics), Aspirin, Atlantic Canada, Łódź Ghetto, Betäubungsmittelgesetz, Binding selectivity, Bioavailability, Bioconjugation, Biological half-life, Biological target, Blood 148, Blood plasma, Blood–brain barrier, Bradycardia, Brain ischemia, Buccal administration, C-SPAN, Calcium channel, Cancer pain, Caning in Singapore, Carbonyl group, Central nervous system, Central Powers, Clearance (pharmacology), Cmax (pharmacology), Codeine, Combination drug, Commissioner of Food and Drugs, Compounding, Constipation, Controlled Drugs and Substances Act, Controlled Substances Act, Convention for Limiting the Manufacture and Regulating the Distribution of Narcotic Drugs, CTV News, Cyclic adenosine monophosphate, CYP2D6, CYP3A, CYP3A4, ... Expand index (214 more) »

Abdominal pain

Abdominal pain, also known as a stomach ache, is a symptom associated with both non-serious and serious medical issues.

See Oxycodone and Abdominal pain

Addiction

Addiction is a neuropsychological disorder characterized by a persistent and intense urge to use a drug or engage in a behavior that produces natural reward, despite substantial harm and other negative consequences.

See Oxycodone and Addiction

Adolf Hitler

Adolf Hitler (20 April 1889 – 30 April 1945) was an Austrian-born German politician who was the dictator of Nazi Germany from 1933 until his suicide in 1945.

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Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

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Alberta

Alberta is one of the thirteen provinces and territories of Canada.

See Oxycodone and Alberta

Analgesic

An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Oxycodone and analgesic are opioids.

See Oxycodone and Analgesic

Annual Reviews (publisher)

Annual Reviews is an independent, non-profit academic publishing company based in San Mateo, California.

See Oxycodone and Annual Reviews (publisher)

Anorexia (symptom)

Anorexia is a medical term for a loss of appetite.

See Oxycodone and Anorexia (symptom)

Anterograde amnesia

In neurology, anterograde amnesia is the inability to create new memories after an event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.

See Oxycodone and Anterograde amnesia

Anxiety

Anxiety is an emotion which is characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events.

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Anxiolytic

An anxiolytic (also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety.

See Oxycodone and Anxiolytic

Apnea

Apnea, BrE: apnoea, is the temporary cessation of breathing.

See Oxycodone and Apnea

Area under the curve (pharmacokinetics)

In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry).

See Oxycodone and Area under the curve (pharmacokinetics)

Aspirin

Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Oxycodone and Aspirin are German inventions and world Health Organization essential medicines.

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Atlantic Canada

Atlantic Canada, also called the Atlantic provinces (provinces de l'Atlantique), is the region of Eastern Canada comprising the provinces located on the Atlantic coast, excluding Quebec.

See Oxycodone and Atlantic Canada

Łódź Ghetto

The Łódź Ghetto or Litzmannstadt Ghetto (after the Nazi German name for Łódź) was a Nazi ghetto established by the German authorities for Polish Jews and Roma following the Invasion of Poland.

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Betäubungsmittelgesetz

The Betäubungsmittelgesetz (BtMG; Narcotics Law) is the controlled substances law of Germany.

See Oxycodone and Betäubungsmittelgesetz

Binding selectivity

In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

See Oxycodone and Binding selectivity

Bioavailability

In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.

See Oxycodone and Bioavailability

Bioconjugation

Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule.

See Oxycodone and Bioconjugation

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

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Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

See Oxycodone and Biological target

Blood 148

Blood 148 is a First Nations reserve in Alberta, Canada.

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Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.

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Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

See Oxycodone and Blood–brain barrier

Bradycardia

Bradycardia, also called bradyarrhythmia, is a resting heart rate under 60 beats per minute (BPM).

See Oxycodone and Bradycardia

Brain ischemia

Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand.

See Oxycodone and Brain ischemia

Buccal administration

Buccal administration is a topical route of administration by which drugs held or applied in the buccal area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream.

See Oxycodone and Buccal administration

C-SPAN

Cable-Satellite Public Affairs Network (C-SPAN) is an American cable and satellite television network, created in 1979 by the cable television industry as a nonprofit public service.

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Calcium channel

A calcium channel is an ion channel which shows selective permeability to calcium ions.

See Oxycodone and Calcium channel

Cancer pain

Pain in cancer may arise from a tumor compressing or infiltrating nearby body parts; from treatments and diagnostic procedures; or from skin, nerve and other changes caused by a hormone imbalance or immune response.

See Oxycodone and Cancer pain

Caning in Singapore

Caning is a widely used form of corporal punishment in Singapore.

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Carbonyl group

For organic chemistry, a carbonyl group is a functional group with the formula, composed of a carbon atom double-bonded to an oxygen atom, and it is divalent at the C atom.

See Oxycodone and Carbonyl group

Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

See Oxycodone and Central nervous system

Central Powers

The Central Powers, also known as the Central Empires,Mittelmächte; Központi hatalmak; İttıfâq Devletleri, Bağlaşma Devletleri; translit were one of the two main coalitions that fought in World War I (1914–1918).

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Clearance (pharmacology)

In pharmacology, clearance (Cl_) is a pharmacokinetic parameter representing the efficiency of drug elimination.

See Oxycodone and Clearance (pharmacology)

Cmax (pharmacology)

Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose.

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Codeine

Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. Oxycodone and Codeine are Catechol ethers and world Health Organization essential medicines.

See Oxycodone and Codeine

Combination drug

A combination drug or a fixed-dose combination (FDC) is a medicine that includes two or more active ingredients combined in a single dosage form.

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Commissioner of Food and Drugs

The United States commissioner of food and drugs is the head of the Food and Drug Administration (FDA), an agency of the United States Department of Health and Human Services.

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Compounding

In the field of pharmacy, compounding (performed in compounding pharmacies) is preparation of custom medications to fit unique needs of patients that cannot be met with mass-produced products.

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Constipation

Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.

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Controlled Drugs and Substances Act

The Controlled Drugs and Substances Act (Loi réglementant certaines drogues et autres substances) is Canada's federal drug control statute.

See Oxycodone and Controlled Drugs and Substances Act

Controlled Substances Act

The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

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Convention for Limiting the Manufacture and Regulating the Distribution of Narcotic Drugs

The Convention for Limiting the Manufacture and Regulating the Distribution of Narcotic Drugs was a drug control treaty promulgated in Geneva on 13 July 1931 that entered into force on 9 July 1933.

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CTV News

CTV News is the news division of the CTV Television Network in Canada.

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Cyclic adenosine monophosphate

Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes.

See Oxycodone and Cyclic adenosine monophosphate

CYP2D6

Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.

See Oxycodone and CYP2D6

CYP3A

Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene locus.

See Oxycodone and CYP3A

CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene.

See Oxycodone and CYP3A4

Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.

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Death

Death is the end of life; the irreversible cessation of all biological functions that sustain a living organism.

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Delirium

Delirium (formerly acute confusional state, an ambiguous term which is now discouraged) is a specific state of acute confusion attributable to the direct physiological consequence of a medical condition, effects of a psychoactive substance, or multiple causes, which usually develops over the course of hours to days.

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Demethylation

Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule.

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Depression (mood)

Depression is a mental state of low mood and aversion to activity.

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Diarrhea

Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day.

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Dizziness

Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness.

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Doctor shopping is the practice of visiting multiple physicians to obtain multiple prescriptions. Oxycodone and Doctor shopping are drug culture.

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Dose (biochemistry)

A dose is a measured quantity of a medicine, nutrient, or pathogen which is delivered as a unit.

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Double bond

In chemistry, a double bond is a covalent bond between two atoms involving four bonding electrons as opposed to two in a single bond.

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Downregulation and upregulation

In biochemistry, in the biological context of organisms' regulation of gene expression and production of gene products, downregulation is the process by which a cell decreases the production and quantities of its cellular components, such as RNA and proteins, in response to an external stimulus.

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Drug interaction

In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs.

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Drug overdose

A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended. Oxycodone and drug overdose are drug culture.

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Drug tolerance

Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.

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Drug withdrawal

Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome, is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs.

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Edmund Speyer

Jakob Edmund Speyer (11 November 1878 – 5 May 1942) was a high-ranking German university lecturer and chemist of Jewish descent.

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Elimination (pharmacology)

In pharmacology, the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.

See Oxycodone and Elimination (pharmacology)

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

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Enzyme inducer

An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme.

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Enzyme inhibitor

An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.

See Oxycodone and Enzyme inhibitor

Ephedrine

Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. Oxycodone and Ephedrine are Euphoriants and world Health Organization essential medicines.

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Epidural administration

Epidural administration (from Ancient Greek ἐπί, "upon" + dura mater) is a method of medication administration in which a medicine is injected into the epidural space around the spinal cord.

See Oxycodone and Epidural administration

Epipactis helleborine

Epipactis helleborine, the broad-leaved helleborine, is a terrestrial species of orchid with a broad distribution.

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Equianalgesic

An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Oxycodone and equianalgesic are opioids.

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Euphoria

Euphoria is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Oxycodone and Euphoria are Euphoriants.

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Excretion

Excretion is elimination of metabolic waste, which is an essential process in all organisms.

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F1000 (publisher)

F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers.

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Fentanyl

Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic. It is 20 to 40 times more potent than heroin and 100 times more potent than morphine; its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. Fentanyl is also used as a sedative. Oxycodone and Fentanyl are Euphoriants, mu-opioid receptor agonists and world Health Organization essential medicines.

See Oxycodone and Fentanyl

Fever

Fever or pyrexia in humans is a body temperature above the normal range due to an increase in the body's temperature set point in the hypothalamus.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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FOSB

Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene.

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Fosphenytoin

Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. Oxycodone and fosphenytoin are drugs developed by Pfizer.

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G protein

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

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Gastrointestinal perforation

Gastrointestinal perforation, also known as gastrointestinal rupture, is a hole in the wall of the gastrointestinal tract. The gastrointestinal tract is composed of hollow digestive organs leading from the mouth to the anus.

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Gastroparesis

Gastroparesis (gastro- from Ancient Greek – gaster, "stomach"; and -paresis, πάρεσις – "partial paralysis"), also called delayed gastric emptying, is a medical disorder consisting of weak muscular contractions (peristalsis) of the stomach, resulting in food and liquid remaining in the stomach for a prolonged period of time.

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Gene polymorphism

A gene is said to be polymorphic if more than one allele occupies that gene's locus within a population.

See Oxycodone and Gene polymorphism

Generic drug

A generic drug (or simply generic) is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents.

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Genetic variation

Genetic variation is the difference in DNA among individuals or the differences between populations among the same species.

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Genotype

The genotype of an organism is its complete set of genetic material.

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German Chemical Society

The German Chemical Society (German: Gesellschaft Deutscher Chemiker, GDCh) is a learned society and professional association founded in 1949 to represent the interests of German chemists in local, national and international contexts.

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Germany

Germany, officially the Federal Republic of Germany (FRG), is a country in Central Europe.

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Gleiwitz incident

The Gleiwitz incident (Überfall auf den Sender Gleiwitz) was a false flag attack on the radio station Sender Gleiwitz in Gleiwitz (then Germany and now Gliwice, Poland) staged by Nazi Germany on the night of 31 August 1939.

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Glucuronic acid

Glucuronic acid (from Greek γλεῦκος "sweet wine, must" and οὖρον "urine") is a uronic acid that was first isolated from urine (hence the name "uronic acid").

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Glucuronidation

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

See Oxycodone and Glucuronidation

Goethe University Frankfurt

Goethe University Frankfurt (Johann Wolfgang Goethe-Universität Frankfurt am Main) is a public research university located in Frankfurt am Main, Germany.

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Half-life

Half-life (symbol) is the time required for a quantity (of substance) to reduce to half of its initial value.

See Oxycodone and Half-life

Hallucination

A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality.

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Health insurance

Health insurance or medical insurance (also known as medical aid in South Africa) is a type of insurance that covers the whole or a part of the risk of a person incurring medical expenses.

See Oxycodone and Health insurance

Heroin

Heroin, also known as diacetylmorphine and diamorphine among other names, is a morphinan opioid substance synthesized from the dried latex of the Papaver somniferum plant; it is mainly used as a recreational drug for its euphoric effects. Oxycodone and Heroin are Euphoriants, mu-opioid receptor agonists, opioids and semisynthetic opioids.

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Hiccup

A hiccup (scientific name singultus, from Latin for "sob, hiccup"; also spelled hiccough) is an involuntary contraction (myoclonic jerk) of the diaphragm that may repeat several times per minute.

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Hydrocodone

Hydrocodone, also known as dihydrocodeinone, is a semisynthetic opioid used to treat pain and as a cough suppressant. Oxycodone and Hydrocodone are Euphoriants, German inventions, mu-opioid receptor agonists and semisynthetic opioids.

See Oxycodone and Hydrocodone

Hydromorphone

Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is a morphinan opioid used to treat moderate to severe pain. Oxycodone and Hydromorphone are Euphoriants, German inventions, mu-opioid receptor agonists, semisynthetic opioids and world Health Organization essential medicines.

See Oxycodone and Hydromorphone

Hydroxy group

In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom.

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Hypogonadism

Hypogonadism means diminished functional activity of the gonads—the testicles or the ovaries—that may result in diminished production of sex hormones.

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Hypotension

Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure.

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Hypoventilation

Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate (hypo meaning "below") to perform needed respiratory gas exchange.

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Hypoxia (medicine)

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.

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Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. Oxycodone and Ibuprofen are world Health Organization essential medicines.

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Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

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In vitro

In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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Influenza-like illness

Influenza-like illness (ILI), also known as flu-like syndrome or flu-like symptoms, is a medical diagnosis of possible influenza or other illness causing a set of common symptoms.

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Injection (medicine)

An injection (often and usually referred to as a "shot" in US English, a "jab" in UK English, or a "jag" in Scottish English and Scots) is the act of administering a liquid, especially a drug, into a person's body using a needle (usually a hypodermic needle) and a syringe.

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Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

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Interleukin 2

Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.

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International Narcotics Control Board

The International Narcotics Control Board (INCB) is an independent treaty body, one of the four treaty-mandated bodies under international drug control law (alongside the Commission on Narcotic Drugs, UNODC on behalf of the Secretary-General, and the WHO).

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Intramuscular injection

Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle.

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Intranasal drug delivery

Intranasal drug delivery occurs when particles are inhaled into the nasal cavity and transported directly into the nervous system.

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Intravenous therapy

Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.

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Intrinsic activity

Intrinsic activity (IA) and efficacy refer to the relative ability of a drug-receptor complex to produce a maximum functional response.

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Irritability

Irritability is the excitatory ability that living organisms have to respond to changes in their environment.

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Itch

An itch (also known as pruritus) is a sensation that causes a strong desire or reflex to scratch.

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Journal of Endocrinological Investigation

The Journal of Endocrinological Investigation is a monthly peer-reviewed medical journal covering endocrinology.

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Ketone

In organic chemistry, a ketone is an organic compound with the structure, where R and R' can be a variety of carbon-containing substituents.

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Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

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League of Nations

The League of Nations (LN or LoN; Société des Nations, SdN) was the first worldwide intergovernmental organisation whose principal mission was to maintain world peace.

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Lethbridge

Lethbridge is a city in the province of Alberta, Canada.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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List of Schedule II controlled substances (U.S.)

This is the list of Schedule II controlled substances in the United States as defined by the Controlled Substances Act.

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Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

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Liver disease

Liver disease, or hepatic disease, is any of many diseases of the liver.

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Liver function tests

Liver function tests (LFTs or LFs), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver.

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Lopinavir/ritonavir

Lopinavir/ritonavir (LPV/r), sold under the brand name Kaletra among others, is a fixed-dose combination antiretroviral medication for the treatment and prevention of HIV/AIDS. Oxycodone and Lopinavir/ritonavir are world Health Organization essential medicines.

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Los Angeles Times

The Los Angeles Times is a regional American daily newspaper that began publishing in Los Angeles, California in 1881.

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Maclean's

Maclean's, founded in 1905, is a Canadian news magazine reporting on Canadian issues such as politics, pop culture, and current events.

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Managed care

The term managed care or managed healthcare is used in the United States to describe a group of activities intended to reduce the cost of providing health care and providing American health insurance while improving the quality of that care ("managed care techniques").

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Mandatory sentencing

Mandatory sentencing requires that offenders serve a predefined term of imprisonment for certain crimes, commonly serious or violent offenses.

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Mania

Mania, also known as manic syndrome, is a mental and behavioral disorder defined as a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." During a manic episode, an individual will experience rapidly changing emotions and moods, highly influenced by surrounding stimuli.

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Martin Freund

Martin Freund (August 13, 1863 in Nysa, Kingdom of Prussia – March 13, 1920 in Frankfurt am Main) was a German chemist and professor at the Goethe-Universität Frankfurt am Main.

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Maura Healey

Maura Tracy Healey (born February 8, 1971) is an American lawyer and politician serving as the 73rd governor of Massachusetts since 2023.

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Merck Group

The Merck Group, branded and commonly known as Merck, is a German multinational science and technology company headquartered in Darmstadt, with about 60,000 employees and a presence in 66 countries.

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Mesolimbic pathway

The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain.

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In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.

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Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

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In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Methamphetamine

Methamphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Oxycodone and Methamphetamine are Euphoriants.

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Microorganism

A microorganism, or microbe, is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from sixth century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek.

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Midbrain

The midbrain or mesencephalon is the rostral-most portion of the brainstem connecting the diencephalon and cerebrum with the pons. It consists of the cerebral peduncles, tegmentum, and tectum.

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Miosis

Miosis, or myosis, is excessive constriction of the pupil.

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Misuse of Drugs Act (Singapore)

The Misuse of Drugs Act 1973 is a statute of the Parliament of Singapore that enables authorities to prosecute offenders for crimes involving illegal drugs.

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Misuse of Drugs Act 1971

The Misuse of Drugs Act 1971 (c. 38) is an act of the Parliament of the United Kingdom.

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Modified-release dosage

Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release dosage) or to a specific target in the body (targeted-release dosage).

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Morphine

Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum). Oxycodone and Morphine are Euphoriants, German inventions, mu-opioid receptor agonists and world Health Organization essential medicines.

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Mortimer Sackler

Mortimer David Sackler (December 7, 1916 – March 24, 2010) was an American-born psychiatrist and entrepreneur who was a co-owner, with his brothers Arthur and Raymond, of Purdue Pharma.

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MSN

MSN (meaning Microsoft Network) is an American web portal and related collection of Internet services and apps for Windows and mobile devices, provided by Microsoft and launched on August 24, 1995, alongside the release of Windows 95.

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Muscle weakness

Muscle weakness is a lack of muscle strength.

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Myalgia

Myalgia or muscle pain is a painful sensation evolving from muscle tissue.

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Naloxegol

Naloxegol (INN; PEGylated naloxol; trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation.

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Naloxone

Naloxone is an opioid antagonist: a medication used to reverse or reduce the effects of opioids. Oxycodone and Naloxone are world Health Organization essential medicines.

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Naltrexone

Naltrexone, sold under the brand name Revia among others, is a medication primarily used to manage alcohol use or opioid use disorder by reducing cravings and feelings of euphoria associated with substance use disorder. It has also been found effective in the treatment of other addictions and may be used for them off-label. Oxycodone and Naltrexone are world Health Organization essential medicines.

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Nasal administration

Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose.

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Natural killer cell

Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system.

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Nature Portfolio

Nature Portfolio (formerly known as Nature Publishing Group and Nature Research) is a division of the international scientific publishing company Springer Nature that publishes academic journals, magazines, online databases, and services in science and medicine.

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Nausea

Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit.

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Netherlands

The Netherlands, informally Holland, is a country located in Northwestern Europe with overseas territories in the Caribbean.

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Neuropeptide

Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons.

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Neuroplasticity

Neuroplasticity, also known as neural plasticity or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization.

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Neurotransmitter

A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.

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Noroxycodone

Noroxycodone is the major metabolite of the opioid analgesic oxycodone.

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Noroxymorphone

Noroxymorphone is an opioid which is both a metabolite of oxymorphone and oxycodone and is manufactured specifically as an intermediate in the production of narcotic antagonists such as naltrexone and others. Oxycodone and Noroxymorphone are Euphoriants, German inventions, mu-opioid receptor agonists and semisynthetic opioids.

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Nucleus accumbens

The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for 'nucleus adjacent to the septum') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.

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Off-label use

Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.

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Onset of action

Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration.

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Ontario

Ontario is the southernmost province of Canada.

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Operation Himmler

Operation Himmler, also called Operation Konserve, consisted of a group of 1939 false flag undertakings planned by Nazi Germany to give the appearance of Polish aggression against Germany.

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Opioid

Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant. Oxycodone and Opioid are opioids.

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Opioid epidemic in the United States

There is an ongoing opioid epidemic (also known as the opioid crisis) in the United States, originating out of both medical prescriptions and illegal sources.

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Opioid withdrawal

Opioid withdrawal is a set of symptoms (a syndrome) arising from the sudden withdrawal or reduction of opioids where previous usage has been heavy and prolonged. Oxycodone and opioid withdrawal are opioids.

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Oral administration

| name.

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Oregon

Oregon is a state in the Pacific Northwest region of the United States.

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Oxandrolone

Oxandrolone is an androgen and synthetic anabolic steroid (AAS) medication to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, to aid in the development of girls with Turner syndrome, and for other indications.

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Oxybutynin

Oxybutynin, sold under the brand name Ditropan among others, is an anticholinergic medication primarily used to treat overactive bladder.

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Oxycodone/aspirin

Oxycodone/aspirin (trade name Percodan) is a combination drug marketed by Endo Pharmaceuticals.

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Oxycodone/ibuprofen

Oxycodone/ibuprofen (INNs, trade name Combunox) is an oral combination drug formulation of the opioid analgesic oxycodone and the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen that is used in the treatment of chronic and acute pain.

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Oxycodone/naloxone

Oxycodone/naloxone, sold under the brand name Targin among others, is a combination pain medication. Oxycodone and Oxycodone/naloxone are semisynthetic opioids.

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Oxycodone/paracetamol

Oxycodone/paracetamol, sold under the brand name Percocet among others, is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.

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Oxymorphol

Oxymorphol is oxymorphone which has been hydrogenated at the 6-position and consists of a mixture of 4,5α-Epoxy-17-methylmorphinan-3,6β,14-triol and 4,5α-Epoxy-17-methylmorphinan-3,6α,14-triol (hydromorphinol). Oxycodone and oxymorphol are mu-opioid receptor agonists and semisynthetic opioids.

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Oxymorphone

Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Oxycodone and Oxymorphone are Euphoriants, German inventions, mu-opioid receptor agonists and semisynthetic opioids.

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Oxytocin

Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary.

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Pain

Pain is a distressing feeling often caused by intense or damaging stimuli.

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Pain management

Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging.

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Panic attack

Panic attacks are sudden periods of intense fear and discomfort that may include palpitations, sweating, chest pain or chest discomfort, shortness of breath, trembling, dizziness, numbness, confusion, or a feeling of impending doom or of losing control.

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Papaver somniferum

Papaver somniferum, commonly known as the opium poppy or breadseed poppy, is a species of flowering plant in the family Papaveraceae.

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Paracetamol

Paracetamol (acetaminophen) is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. Oxycodone and Paracetamol are world Health Organization essential medicines.

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Periaqueductal gray

The periaqueductal gray (PAG, also known as the central gray) is a brain region that plays a critical role in autonomic function, motivated behavior and behavioural responses to threatening stimuli.

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Perspiration

Perspiration, also known as sweat, is the fluid secreted by sweat glands in the skin of mammals.

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Pethidine

Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a fully synthetic opioid pain medication of the phenylpiperidine class. Oxycodone and Pethidine are Euphoriants and mu-opioid receptor agonists.

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Pfizer

Pfizer Inc. is an American multinational pharmaceutical and biotechnology corporation headquartered at The Spiral in Manhattan, New York City.

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Pharmacogenomics

Pharmacogenomics, often abbreviated "PGx," is the study of the role of the genome in drug response.

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Potassium channel

Potassium channels are the most widely distributed type of ion channel found in virtually all organisms.

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Potency (pharmacology)

In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.

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Prolactin

Prolactin (PRL), also known as lactotropin and mammotropin, is a protein best known for its role in enabling mammals to produce milk.

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Pseudomonas putida

Pseudomonas putida is a Gram-negative, rod-shaped, saprophytic soil bacterium.

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Purdue Pharma

Purdue Pharma L.P., formerly the Purdue Frederick Company (1892–2019), was an American privately held pharmaceutical company founded by John Purdue Gray.

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Quality of life

Quality of life (QOL) is defined by the World Health Organization as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns".

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Rectal administration

Rectal administration (colloquially known as boofing or plugging) uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels,The rectum has numerous blood vessels available to absorb drugs: upwards 2/3rds of the dose bypasses first-pass metabolism through systemic distribution and the rest is taken through the liver and metabolized via the hepatic portal system.

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Redox

Redox (reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change.

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Reinforcement

In behavioral psychology, reinforcement refers to consequences that increase the likelihood of an organism's future behavior, typically in the presence of a particular antecedent stimulus.

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Relaxation (psychology)

In psychology, relaxation is the emotional state of low tension, in which there is an absence of arousal, particularly from negative sources such as anger, anxiety, or fear.

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Respiratory arrest

Respiratory arrest is a serious medical condition caused by apnea or respiratory dysfunction severe enough that it will not sustain the body (such as agonal breathing).

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Restless legs syndrome

Restless legs syndrome, also known as restless leg syndrome (RLS), also known as Willis–Ekbom disease (WED), is a neurological disorder, usually chronic, that causes an overwhelming urge to move one's legs.

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Reward system

The reward system (the mesocorticolimbic circuit) is a group of neural structures responsible for incentive salience (i.e., "wanting"; desire or craving for a reward and motivation), associative learning (primarily positive reinforcement and classical conditioning), and positively-valenced emotions, particularly ones involving pleasure as a core component (e.g., joy, euphoria and ecstasy).

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Richard Nixon

Richard Milhous Nixon (January 9, 1913April 22, 1994) was an American politician and lawyer who served as the 37th president of the United States from 1969 to 1974.

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Richard Sackler

Richard Stephen Sackler (born March 10, 1945) is an American billionaire businessman and physician who was the chairman and president of Purdue Pharma, a former company best known as the developer of OxyContin, whose initiation of the opioid epidemic in the United States became the subject of many lawsuits and fines, filing for bankruptcy in 2019.

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Rifampicin

Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), ''Mycobacterium avium'' complex, leprosy, and Legionnaires' disease. Oxycodone and Rifampicin are world Health Organization essential medicines.

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Ritonavir

Ritonavir, sold under the brand name Norvir, is an antiretroviral medication used along with other medications to treat HIV/AIDS. Oxycodone and Ritonavir are world Health Organization essential medicines.

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The rostral ventromedial medulla (RVM), or ventromedial nucleus of the spinal cord, is a group of neurons located close to the midline on the floor of the medulla oblongata (which develops from myelencephalon in embryonic development).

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Route of administration

In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body.

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Saccharomyces cerevisiae

Saccharomyces cerevisiae (brewer's yeast or baker's yeast) is a species of yeast (single-celled fungal microorganisms).

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Sackler family

The Sackler family is an American family who owned the pharmaceutical company Purdue Pharma and later founded Mundipharma.

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San Francisco Chronicle

The San Francisco Chronicle is a newspaper serving primarily the San Francisco Bay Area of Northern California.

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Scopolamine

Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is used as a medication to treat motion sickness and postoperative nausea and vomiting. Oxycodone and Scopolamine are world Health Organization essential medicines.

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Semisynthesis

Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds with distinct chemical and medicinal properties.

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Sex hormone

Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors.

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Shallow breathing

Shallow breathing, thoracic breathing, costal breathing or chest breathing is the drawing of minimal breath into the lungs, usually by drawing air into the chest area using the intercostal muscles rather than throughout the lungs via the diaphragm.

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Shock (circulatory)

Shock is the state of insufficient blood flow to the tissues of the body as a result of problems with the circulatory system.

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Shortness of breath

Shortness of breath (SOB), known as dyspnea (in AmE) or dyspnoea (in BrE), is an uncomfortable feeling of not being able to breathe well enough.

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Single Convention on Narcotic Drugs

The Single Convention on Narcotic Drugs, 1961 (Single Convention, 1961 Convention, or C61) is a United Nations treaty that controls activities (cultivation, production, supply, trade, transport) of specific narcotic drugs and lays down a system of regulations (licenses, measures for treatment, research, etc.) for their medical and scientific uses; it also establishes the International Narcotics Control Board.

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Skeletal muscle

Skeletal muscle (commonly referred to as muscle) is one of the three types of vertebrate muscle tissue, the other being cardiac muscle and smooth muscle.

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Somnolence

Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

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Spain

Spain, formally the Kingdom of Spain, is a country located in Southwestern Europe, with parts of its territory in the Atlantic Ocean, the Mediterranean Sea and Africa.

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Spleen

The spleen is an organ found in almost all vertebrates.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Subcutaneous administration

Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion.

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Sublingual administration

Sublingual (abbreviated SL), from the Latin for "under the tongue", refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue.

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Substance abuse

Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others.

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Substance dependence

Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption of the drug.

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Suppository

A suppository is a dosage form used to deliver medications by insertion into a body orifice (any opening in the body), where it dissolves or melts to exert local or systemic effects.

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Testosterone

Testosterone is the primary male sex hormone and androgen in males.

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The Holocaust

The Holocaust was the genocide of European Jews during World War II.

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The New York Times

The New York Times (NYT) is an American daily newspaper based in New York City.

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The New Yorker

The New Yorker is an American magazine featuring journalism, commentary, criticism, essays, fiction, satire, cartoons, and poetry.

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Thebaine

Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, Thēbai (Thebes), an ancient city in Upper Egypt.

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Theodor Morell

Theodor Gilbert Morell (22 July 1886 – 26 May 1948) was a German medical doctor known for acting as Adolf Hitler's personal physician.

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Transdermal

Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution.

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Transgene

A transgene is a gene that has been transferred naturally, or by any of a number of genetic engineering techniques, from one organism to another.

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Treaty

A treaty is a formal, legally binding written agreement concluded by sovereign states in international law.

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Twilight sleep

Twilight sleep (English translation of the German word Dämmerschlaf) is an amnesic state characterized by insensitivity to pain with or without the loss of consciousness, induced by an injection of morphine and scopolamine, with the purpose of pain management during childbirth.

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UGT2B7

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

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UNESCO

The United Nations Educational, Scientific and Cultural Organization (UNESCO; pronounced) is a specialized agency of the United Nations (UN) with the aim of promoting world peace and security through international cooperation in education, arts, sciences and culture.

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United Kingdom

The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of the continental mainland.

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United Nations

The United Nations (UN) is a diplomatic and political international organization whose stated purposes are to maintain international peace and security, develop friendly relations among nations, achieve international cooperation, and serve as a centre for harmonizing the actions of nations.

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United States Department of Health and Human Services

The United States Department of Health and Human Services (HHS) is a cabinet-level executive branch department of the U.S. federal government created to protect the health of the U.S. people and providing essential human services.

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Urinary retention

Urinary retention is an inability to completely empty the bladder.

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Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

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Ventral pallidum

The ventral pallidum (VP) is a structure within the basal ganglia of the brain.

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Ventral tegmental area

The ventral tegmental area (VTA) (tegmentum is Latin for covering), also known as the ventral tegmental area of Tsai, or simply ventral tegmentum, is a group of neurons located close to the midline on the floor of the midbrain.

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Volume of distribution

In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, volume of dilution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.

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Vomiting

Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.

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Wehrmacht

The Wehrmacht were the unified armed forces of Nazi Germany from 1935 to 1945.

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Western Canada

Western Canada, also referred to as the Western provinces, Canadian West or the Western provinces of Canada, and commonly known within Canada as the West, is a Canadian region that includes the four western provinces just north of the Canada–United States border namely (from west to east) British Columbia, Alberta, Saskatchewan and Manitoba.

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WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. Oxycodone and WHO Model List of Essential Medicines are world Health Organization essential medicines.

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World War I

World War I (alternatively the First World War or the Great War) (28 July 1914 – 11 November 1918) was a global conflict between two coalitions: the Allies (or Entente) and the Central Powers.

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Xerostomia

Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.

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References

[1] https://en.wikipedia.org/wiki/Oxycodone

Also known as 14-Hydroxydihydrocodeinone, ATC code N02AA05, ATCvet code QN02AA05, Dihydro-oxycodeinone, Dihydrohydrooxycodeinone, Dihydrohydroxycodeinone, Dihydroxycodeinone, Dinarkon, Diphydrone, Endocodil, Endodan, Endone, Eubine, Eucodal, Eucodalum, Eukadol, Eukodal, Eutagen, Hillbilly Heroine, Hillbilly heroin, Nucodan, OcyContin, Oxanest, Oxecta, Oxicon, Oxicone, Oxikon, Oxy 80, Oxy Cotton, Oxy IR, Oxy-contin, Oxy80, OxyContin, OxyFAST, OxyIR, OxyNorm, Oxycod, Oxycodeinone, Oxycodon, Oxycodone Hydrochloride, Oxycodone hcl, Oxycodone terephthalate, Oxycon, Oxycotin, Oxycotton, Oxydose, Oxyneo, Oxytrex, Oxy·IR, Pancodine, Percicet, Percobarb, Percolone, Perdocan, Remoxy, Roxicodone, Roxies, Roxiprin, Side effects of oxycodone, Supendol, Supeudol, Tecodin, Tecodine, Tekodin, Thecodine, Thekodin, Troxyca, Xtampza, Xtampza Er.

, Cytochrome P450, Death, Delirium, Demethylation, Depression (mood), Diarrhea, Dizziness, Doctor shopping, Dose (biochemistry), Double bond, Downregulation and upregulation, Drug interaction, Drug overdose, Drug tolerance, Drug withdrawal, Edmund Speyer, Elimination (pharmacology), Endogeny (biology), Enzyme, Enzyme inducer, Enzyme inhibitor, Ephedrine, Epidural administration, Epipactis helleborine, Equianalgesic, Euphoria, Excretion, F1000 (publisher), Fentanyl, Fever, Food and Drug Administration, FOSB, Fosphenytoin, G protein, Gastrointestinal perforation, Gastroparesis, Gene polymorphism, Generic drug, Genetic variation, Genotype, German Chemical Society, Germany, Gleiwitz incident, Glucuronic acid, Glucuronidation, Goethe University Frankfurt, Half-life, Hallucination, Health insurance, Heroin, Hiccup, Hydrocodone, Hydromorphone, Hydroxy group, Hypogonadism, Hypotension, Hypoventilation, Hypoxia (medicine), Ibuprofen, Immunosuppression, In vitro, Influenza-like illness, Injection (medicine), Insomnia, Interleukin 2, International Narcotics Control Board, Intramuscular injection, Intranasal drug delivery, Intravenous therapy, Intrinsic activity, Irritability, Itch, Journal of Endocrinological Investigation, Ketone, Kidney, League of Nations, Lethbridge, Ligand (biochemistry), List of Schedule II controlled substances (U.S.), Liver, Liver disease, Liver function tests, Lopinavir/ritonavir, Los Angeles Times, Maclean's, Managed care, Mandatory sentencing, Mania, Martin Freund, Maura Healey, Merck Group, Mesolimbic pathway, Metabolic pathway, Metabolism, Metabolite, Methamphetamine, Microorganism, Midbrain, Miosis, Misuse of Drugs Act (Singapore), Misuse of Drugs Act 1971, Modified-release dosage, Morphine, Mortimer Sackler, MSN, Muscle weakness, Myalgia, Naloxegol, Naloxone, Naltrexone, Nasal administration, Natural killer cell, Nature Portfolio, Nausea, Netherlands, Neuropeptide, Neuroplasticity, Neurotransmitter, Noroxycodone, Noroxymorphone, Nucleus accumbens, Off-label use, Onset of action, Ontario, Operation Himmler, Opioid, Opioid epidemic in the United States, Opioid withdrawal, Oral administration, Oregon, Oxandrolone, Oxybutynin, Oxycodone/aspirin, Oxycodone/ibuprofen, Oxycodone/naloxone, Oxycodone/paracetamol, Oxymorphol, Oxymorphone, Oxytocin, Pain, Pain management, Panic attack, Papaver somniferum, Paracetamol, Periaqueductal gray, Perspiration, Pethidine, Pfizer, Pharmacogenomics, Potassium channel, Potency (pharmacology), Prolactin, Pseudomonas putida, Purdue Pharma, Quality of life, Rectal administration, Redox, Reinforcement, Relaxation (psychology), Respiratory arrest, Restless legs syndrome, Reward system, Richard Nixon, Richard Sackler, Rifampicin, Ritonavir, Rostral ventromedial medulla, Route of administration, Saccharomyces cerevisiae, Sackler family, San Francisco Chronicle, Scopolamine, Semisynthesis, Sex hormone, Shallow breathing, Shock (circulatory), Shortness of breath, Single Convention on Narcotic Drugs, Skeletal muscle, Somnolence, Spain, Spleen, Structural analog, Subcutaneous administration, Sublingual administration, Substance abuse, Substance dependence, Suppository, Testosterone, The Holocaust, The New York Times, The New Yorker, Thebaine, Theodor Morell, Transdermal, Transgene, Treaty, Twilight sleep, UGT2B7, UNESCO, United Kingdom, United Nations, United States Department of Health and Human Services, Urinary retention, Urine, Ventral pallidum, Ventral tegmental area, Volume of distribution, Vomiting, Wehrmacht, Western Canada, WHO Model List of Essential Medicines, World War I, Xerostomia.