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Prasterone, the Glossary

Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for childbirth, among other uses.^[1]

170 relations: Acne, Active ingredient, Addison's disease, Adipose tissue, Adolf Butenandt, Adrenal gland, Adrenal insufficiency, Ageing, Agonist, Alzheimer's disease, American Cancer Society, Anabolic steroid, Androgen, Androgen receptor, Androstane, Androstanediol, Androstanolone, Androstenediol, Androstenedione, Androsterone, Antidepressant, Aromatase, Atrophic vaginitis, Australia, BBC Sport, Benign prostatic hyperplasia, Bile salt sulfotransferase, Biological activity, Biological target, Biosynthesis, Biotransformation, Blood plasma, Bodybuilding, Breast cancer, Canada, Cancer, Cardiovascular disease, Cervical dilation, Cervical effacement, Cervix, Childbirth, Cholesterol, Clinical trial, Dénomination Commune Française, Dehydroepiandrosterone, Dehydroepiandrosterone sulfate, Dehydrogenation, Denominazione Comune Italiana, Diabetes, Diário Oficial da União, ... Expand index (120 more) »
NMDA receptor agonists
Pregnane X receptor agonists
Sex hormone esters and conjugates

Acne

Acne, also known as acne vulgaris, is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles.

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Active ingredient

An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals.

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Addison's disease

Addison's disease, also known as primary adrenal insufficiency, is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands (adrenal cortex), causing adrenal insufficiency.

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Adipose tissue

Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes.

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Adolf Butenandt

Adolf Friedrich Johann Butenandt (24 March 1903 – 18 January 1995) was a German biochemist.

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Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

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Adrenal insufficiency

Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones.

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Ageing

Ageing (or aging in American English) is the process of becoming older.

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Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

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Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia.

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American Cancer Society

The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer.

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Anabolic steroid

Anabolic steroids, also known as anabolic-androgenic steroids (AAS), are a class of drugs that are structurally related to testosterone, the main male sex hormone, and produce effects by binding to the androgen receptor (AR). Prasterone and anabolic steroid are anabolic–androgenic steroids.

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Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. Prasterone and androgen are anabolic–androgenic steroids.

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Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus.

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Androstane

Androstane is a C19 steroidal hydrocarbon with a gonane core. Prasterone and Androstane are anabolic–androgenic steroids and androstanes.

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Androstanediol

Androstanediol may refer to. Prasterone and Androstanediol are androstanes.

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Androstanolone

Androstanolone, or stanolone, also known as dihydrotestosterone (DHT) and sold under the brand name Andractim among others, is an androgen and anabolic steroid (AAS) medication and hormone which is used mainly in the treatment of low testosterone levels in men. Prasterone and Androstanolone are anabolic–androgenic steroids, androstanes and estrogens.

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Androstenediol

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). Prasterone and Androstenediol are anabolic–androgenic steroids, androstanes, estrogens and pregnane X receptor agonists.

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Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA). Prasterone and Androstenedione are anabolic–androgenic steroids, androstanes, estrogens and pregnane X receptor agonists.

See Prasterone and Androstenedione

Androsterone

Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. Prasterone and Androsterone are anabolic–androgenic steroids, androstanes and neurosteroids.

See Prasterone and Androsterone

Antidepressant

Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.

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Aromatase

Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.

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Atrophic vaginitis

Atrophic vaginitis is inflammation of the vagina as a result of tissue thinning due to low estrogen levels.

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Australia

Australia, officially the Commonwealth of Australia, is a country comprising the mainland of the Australian continent, the island of Tasmania, and numerous smaller islands.

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BBC Sport

BBC Sport is the sports division of the BBC, providing national sports coverage for BBC television, radio and online.

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Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland.

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Bile salt sulfotransferase

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

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Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

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Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

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Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

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Biotransformation

Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds.

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Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.

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Bodybuilding

Bodybuilding is the practice of progressive resistance exercise to build, control, and develop one's muscles via hypertrophy.

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Breast cancer

Breast cancer is a cancer that develops from breast tissue.

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Canada

Canada is a country in North America.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cardiovascular disease

Cardiovascular disease (CVD) is any disease involving the heart or blood vessels.

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Cervical dilation

Cervical dilation (or cervical dilatation) is the opening of the cervix, the entrance to the uterus, during childbirth, miscarriage, induced abortion, or gynecological surgery.

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Cervical effacement

Cervical effacement or cervical ripening refers to the thinning and shortening of the cervix.

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Cervix

The cervix (cervices) or cervix uteri is a dynamic fibromuscular organ of the female reproductive system that connects the vagina with the uterine cavity.

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Childbirth

Childbirth, also known as labour, parturition and delivery, is the completion of pregnancy where one or more babies exits the internal environment of the mother via vaginal delivery or caesarean section.

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Cholesterol

Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Prasterone and Cholesterol are neurosteroids.

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Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.

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Dénomination Commune Française

The Dénomination Commune Française (DCF), or "Common French Denomination/Name" in English, is the formal French name for a drug.

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Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. Prasterone and Dehydroepiandrosterone are anabolic–androgenic steroids, androstanes, estrogens, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists and Sigma agonists.

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Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. Prasterone and Dehydroepiandrosterone sulfate are anabolic–androgenic steroids, androstanes, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists and Sigma agonists.

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Dehydrogenation

In chemistry, dehydrogenation is a chemical reaction that involves the removal of hydrogen, usually from an organic molecule.

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Denominazione Comune Italiana

The Denominazione Comune Italiana (DCIT), or "Common Italian Denomination/Name" in English, is the formal Italian generic name for a drug.

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Diabetes

Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels.

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Diário Oficial da União

The Diário Oficial da União (literally Official Diary of the Union), abbreviated DOU, is the official journal of the federal government of Brazil.

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Dietary supplement

A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill, capsule, tablet, powder, or liquid. Prasterone and dietary supplement are dietary supplements.

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Dietary Supplement Health and Education Act of 1994

The Dietary Supplement Health and Education Act of 1994 ("DSHEA"), is a 1994 statute of United States Federal legislation which defines and regulates dietary supplements.

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Dihydrotestosterone

Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition. Prasterone and Dihydrotestosterone are anabolic–androgenic steroids and androstanes.

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Drug Enforcement Administration

The Drug Enforcement Administration (DEA) is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating illicit drug trafficking and distribution within the U.S. It is the lead agency for domestic enforcement of the Controlled Substances Act, sharing concurrent jurisdiction with the Federal Bureau of Investigation, the U.S.

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Drugs controlled by the UK Misuse of Drugs Act

These drugs are known in the UK as controlled drug, because this is the term by which the act itself refers to them.

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Dyspareunia

Dyspareunia is painful sexual intercourse due to medical or psychological causes.

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English language

English is a West Germanic language in the Indo-European language family, whose speakers, called Anglophones, originated in early medieval England on the island of Great Britain.

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Epiandrosterone

Epiandrosterone, or isoandrosterone, also known as 3β-androsterone, 3β-hydroxy-5α-androstan-17-one, or 5α-androstan-3β-ol-17-one, is a steroid hormone with weak androgenic activity. Prasterone and Epiandrosterone are anabolic–androgenic steroids and androstanes.

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Ester

In chemistry, an ester is a functional group derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group of that acid is replaced by an organyl group.

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Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Prasterone and Estradiol are estrogens.

See Prasterone and Estradiol

Estradiol (medication)

Estradiol (E2) is a medication and naturally occurring steroid hormone. Prasterone and Estradiol (medication) are estrogens.

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Estradiol valerate

Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication.

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Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Prasterone and Estrogen are estrogens.

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Estrogen (medication)

An estrogen (E) is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy, and as part of feminizing hormone therapy for transgender women. Prasterone and estrogen (medication) are estrogens.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. Prasterone and Estrone are estrogens.

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Estrone (medication)

Estrone (E1), sold under the brand names Estragyn, Kestrin, and Theelin among many others, is an estrogen medication and naturally occurring steroid hormone which has been used in menopausal hormone therapy and for other indications. Prasterone and Estrone (medication) are estrogens and sex hormone esters and conjugates.

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Etiocholanolone

Etiocholanolone, also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. Prasterone and Etiocholanolone are neurosteroids and world Anti-Doping Agency prohibited substances.

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Europe

Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.

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Fábio Maldonado

Fábio Rogério Maldonado (born 17 March 1980) is a Brazilian professional mixed martial artist and boxer.

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Fluasterone

Fluasterone, also known as 3β-dehydroxy-16α-fluoro- or 16α-fluoroandrost-5-en-17-one, is a fluorinated synthetic analogue of dehydroepiandrosterone (DHEA) which was under investigation by Aeson Therapeutics for a variety of therapeutic indications including cancer, cardiovascular diseases, diabetes, obesity, and traumatic brain injury among others but was ultimately never marketed. Prasterone and Fluasterone are androstanes.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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French language

French (français,, or langue française,, or by some speakers) is a Romance language of the Indo-European family.

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Glucose-6-phosphate dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) is a cytosolic enzyme that catalyzes the chemical reaction This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the reduced form of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH).

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Grandfather clause

A grandfather clause, also known as grandfather policy, grandfathering, or being grandfathered in, is a provision in which an old rule continues to apply to some existing situations while a new rule will apply to all future cases.

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Gynecomastia

Gynecomastia (also spelled gynaecomastia) is the abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens.

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Hair follicle

The hair follicle is an organ found in mammalian skin.

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Headache

Headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck.

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Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

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High-density lipoprotein

High-density lipoprotein (HDL) is one of the five major groups of lipoproteins.

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Hirsutism

Hirsutism is excessive body hair on parts of the body where hair is normally absent or minimal.

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Hormone replacement therapy

Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause.

See Prasterone and Hormone replacement therapy

Human skin

The human skin is the outer covering of the body and is the largest organ of the integumentary system.

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Hydrocortisone

Hydrocortisone is the name for the hormone cortisol when supplied as a medication.

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Injection (medicine)

An injection (often and usually referred to as a "shot" in US English, a "jab" in UK English, or a "jag" in Scottish English and Scots) is the act of administering a liquid, especially a drug, into a person's body using a needle (usually a hypodermic needle) and a syringe.

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Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

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International nonproprietary name

An international nonproprietary name (INN) is an official generic and nonproprietary name given to a pharmaceutical drug or an active ingredient.

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International Tennis Federation

The International Tennis Federation (ITF) is the governing body of world tennis, wheelchair tennis, and beach tennis.

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Intramuscular injection

Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle.

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Intravaginal administration

Intravaginal administration is a route of administration where the substance is applied inside the vagina.

See Prasterone and Intravaginal administration

Italian language

Italian (italiano,, or lingua italiana) is a Romance language of the Indo-European language family that evolved from the Vulgar Latin of the Roman Empire.

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Japan

Japan is an island country in East Asia, located in the Pacific Ocean off the northeast coast of the Asian mainland.

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Ketosteroid

Androstenedione Androsterone Estrone A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C.

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King Features Syndicate

King Features Syndicate, Inc. is an American content distribution and animation studio, consumer product licensing and print syndication company owned by Hearst Communications that distributes about 150 comic strips, newspaper columns, editorial cartoons, puzzles, and games to nearly 5,000 newspapers worldwide.

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LaShawn Merritt

LaShawn Merritt (born June 27, 1986) is an American track and field athlete who competes in sprinting events, specializing in the 400 metres.

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Latin

Latin (lingua Latina,, or Latinum) is a classical language belonging to the Italic branch of the Indo-European languages.

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Libido

In psychology, libido (from the Latin, 'desire') is psychic drive or energy, usually conceived as sexual in nature, but sometimes conceived as including other forms of desire. Prasterone and libido are estrogens.

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Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

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Lupus

Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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Mechanism of action

In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.

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Medication

A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

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Micronization

Micronization is the process of reducing the average diameter of a solid material's particles.

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Mixed martial arts

Mixed martial arts (MMA) is a full-contact combat sport based on striking, grappling and ground fighting, incorporating techniques from various combat sports from around the world.

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Nandrolone

Nandrolone, also known as 19-nortestosterone, is an endogenous androgen which exists in the male body at a ratio of 1:50 compared to testosterone. Prasterone and Nandrolone are anabolic–androgenic steroids and estrogens.

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National Basketball Association

The National Basketball Association (NBA) is a professional basketball league in North America composed of 30 teams (29 in the United States and 1 in Canada).

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Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

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Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Prasterone and Neurosteroid are neurosteroids.

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New Drug Application

The Food and Drug Administration's (FDA) New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.

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New Zealand

New Zealand (Aotearoa) is an island country in the southwestern Pacific Ocean.

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Nor-

In chemical nomenclature, nor- is a prefix to name a structural analog that can be derived from a parent compound by the removal of one carbon atom along with the accompanying hydrogen atoms.

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O. J. Mayo

Ovinton J'Anthony Mayo (born November 5, 1987) is an American professional basketball player who plays for Zamalek SC of the Egyptian Basketball Super League and Egyptian Basketball Federation.

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Oral administration

| name.

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Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescription.

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Pharmacodynamics

Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).

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Polycystic ovary syndrome

Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age.

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Prasterone enanthate

Prasterone enanthate, also known as dehydroepiandrosterone enanthate (DHEA-E) and sold in combination with estradiol valerate under the brand name Gynodian Depot among others, is a weak androgen, estrogen, and neurosteroid medication which is used as a component of menopausal hormone therapy to treat menopausal symptoms in women. Prasterone and Prasterone enanthate are anabolic–androgenic steroids, androstanes, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists, sex hormone esters and conjugates, Sigma agonists and world Anti-Doping Agency prohibited substances.

See Prasterone and Prasterone enanthate

Prasterone sulfate

Prasterone sulfate (brand names Astenile, Mylis, Teloin, others), also known as dehydroepiandrosterone sulfate (DHEA-S), is a naturally occurring androstane steroid which is marketed and used in Japan and other countries as a labor inducer in the treatment of insufficient cervical ripening and dilation during childbirth. Prasterone and Prasterone sulfate are anabolic–androgenic steroids, androstanes, estrogens, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists, sex hormone esters and conjugates and Sigma agonists.

See Prasterone and Prasterone sulfate

Print syndication

Print syndication distributes news articles, columns, political cartoons, comic strips and other features to newspapers, magazines and websites.

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Prodrug

A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

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Prohormone

A prohormone is a committed precursor of a hormone consisting of peptide hormones synthesized together that has a minimal hormonal effect by itself because of its expression-suppressing structure, often created by protein folding and binding additional peptide chains to certain ends, that makes hormone receptor binding sites located on its peptide hormone chain segments inaccessible.

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Prostate

The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation.

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Prostate cancer

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.

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In chemistry, a reaction intermediate, or intermediate, is a molecular entity arising within the sequence of a stepwise chemical reaction.

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Rectal administration

Rectal administration (colloquially known as boofing or plugging) uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels,The rectum has numerous blood vessels available to absorb drugs: upwards 2/3rds of the dose bypasses first-pass metabolism through systemic distribution and the rest is taken through the liver and metabolized via the hepatic portal system.

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Salt (chemistry)

In chemistry, a salt or ionic compound is a chemical compound consisting of an assembly of positively charged ions (cations) and negatively charged ions (anions), which results in a compound with no net electric charge (electrically neutral).

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Sexual desire

Sexual desire is an emotion and motivational state characterized by an interest in sexual objects or activities, or by a drive to seek out sexual objects or to engage in sexual activities.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Signs and symptoms

Signs and symptoms are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition.

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Skin

Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation.

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Sodium

Sodium is a chemical element; it has symbol Na (from Neo-Latin natrium) and atomic number 11.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Steroid hormone

A steroid hormone is a steroid that acts as a hormone.

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Steroid sulfatase

Steroid sulfatase (STS), or steryl-sulfatase (EC 3.1.6.2), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids.

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Steroid sulfotransferase

In enzymology, a steroid sulfotransferase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and phenolic steroid, whereas its two products are adenosine 3',5'-bisphosphate and steroid O-sulfate.

See Prasterone and Steroid sulfotransferase

Stroke

Stroke (also known as a cerebrovascular accident (CVA) or brain attack) is a medical condition in which poor blood flow to the brain causes cell death.

See Prasterone and Stroke

Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

See Prasterone and Structural analog

Structural isomer

In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is another compound whose molecule has the same number of atoms of each element, but with logically distinct bonds between them.

See Prasterone and Structural isomer

Sulfate

The sulfate or sulphate ion is a polyatomic anion with the empirical formula.

See Prasterone and Sulfate

SULT1E1

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.

See Prasterone and SULT1E1

Suppository

A suppository is a dosage form used to deliver medications by insertion into a body orifice (any opening in the body), where it dissolves or melts to exert local or systemic effects.

See Prasterone and Suppository

Tablet (pharmacy)

A tablet (also known as a pill) is a pharmaceutical oral dosage form (oral solid dosage, or OSD) or solid unit dosage form.

See Prasterone and Tablet (pharmacy)

Tamoxifen

Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men.

See Prasterone and Tamoxifen

Testosterone

Testosterone is the primary male sex hormone and androgen in males. Prasterone and Testosterone are anabolic–androgenic steroids, androstanes and estrogens.

See Prasterone and Testosterone

Testosterone (medication)

Testosterone (T) is a medication and naturally occurring steroid hormone. Prasterone and Testosterone (medication) are anabolic–androgenic steroids, androstanes and estrogens.

See Prasterone and Testosterone (medication)

Tissue (biology)

In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function.

See Prasterone and Tissue (biology)

Tissue selectivity

Tissue selectivity is a topic in distribution (pharmacology) and property of some drugs.

See Prasterone and Tissue selectivity

Trademark distinctiveness

Trademark distinctiveness is an important concept in the law governing trademarks and service marks.

See Prasterone and Trademark distinctiveness

Transdermal

Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution.

See Prasterone and Transdermal

Ultimate Fighting Championship

The Ultimate Fighting Championship (UFC) is an American mixed martial arts (MMA) promotion company based in Las Vegas, Nevada.

See Prasterone and Ultimate Fighting Championship

United Kingdom

The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of the continental mainland.

See Prasterone and United Kingdom

United States

The United States of America (USA or U.S.A.), commonly known as the United States (US or U.S.) or America, is a country primarily located in North America.

See Prasterone and United States

United States Adopted Name

A United States Adopted Name (USAN) is a unique nonproprietary name assigned to a medication marketed in the United States.

See Prasterone and United States Adopted Name

Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

See Prasterone and Urine

Uterine cancer

Uterine cancer, also known as womb cancer, includes two types of cancer that develop from the tissues of the uterus.

See Prasterone and Uterine cancer

Vagina

In mammals and other animals, the vagina (vaginas or vaginae) is the elastic, muscular reproductive organ of the female genital tract.

See Prasterone and Vagina

Venus Williams

Venus Ebony Starr Williams (born June 17, 1980) is an American professional tennis player.

See Prasterone and Venus Williams

Virilization

Virilization or masculinization is the biological development of adult male characteristics in young males or females.

See Prasterone and Virilization

Voice change

A voice change or voice mutation, sometimes referred to as a voice break or voice crack, commonly refers to the deepening of the voice of men as they reach puberty.

See Prasterone and Voice change

Volume of distribution

In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, volume of dilution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.

See Prasterone and Volume of distribution

Weight loss

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue).

See Prasterone and Weight loss

World Anti-Doping Agency

The World Anti-Doping Agency (WADA; Agence mondiale antidopage, AMA) is a foundation initiated by the International Olympic Committee based in Canada to promote, coordinate, and monitor the fight against drugs in sports.

See Prasterone and World Anti-Doping Agency

Yuliya Yefimova

Yuliya Andreyevna Yefimova (Юлия Андреевна Ефимова, also romanized Efimova; born 3 April 1992) is a Russian competitive swimmer.

See Prasterone and Yuliya Yefimova

1-Androsterone

1-Androsterone (also known as 1-andro, 1-dehydroepiandrosterone, 1-DHEA, δ1-epiandrosterone, or 5α-androst-1-en-3β-ol-17-one) is a synthetic, orally active anabolic-androgenic steroid (AAS). Prasterone and 1-Androsterone are anabolic–androgenic steroids and androstanes.

See Prasterone and 1-Androsterone

1-Testosterone

1-Testosterone (abbreviated and nicknamed as 1-Testo, 1-T), also known as δ1-dihydrotestosterone (δ1-DHT), as well as dihydroboldenone, is a synthetic anabolic–androgenic steroid (AAS) and a 5α-reduced derivative of boldenone (Δ1-testosterone). Prasterone and 1-Testosterone are anabolic–androgenic steroids and androstanes.

See Prasterone and 1-Testosterone

17β-Hydroxysteroid dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.

See Prasterone and 17β-Hydroxysteroid dehydrogenase

19-Nordehydroepiandrosterone

19-Nordehydroepiandrosterone (19-nor-DHEA), or 19-nor-5-dehydroepiandrosterone (19-nor-5-DHEA), is an estrane (19-norandrostane) steroid which was never marketed. Prasterone and 19-Nordehydroepiandrosterone are anabolic–androgenic steroids, estrogens and sex hormone esters and conjugates.

See Prasterone and 19-Nordehydroepiandrosterone

3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

See Prasterone and 3β-Hydroxysteroid dehydrogenase

4-Dehydroepiandrosterone

4-Dehydroepiandrosterone (4-DHEA) is a steroid that is an isomer of 5-dehydroepiandrosterone. Prasterone and 4-Dehydroepiandrosterone are anabolic–androgenic steroids and androstanes.

See Prasterone and 4-Dehydroepiandrosterone

5α-Reductase

5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.

See Prasterone and 5α-Reductase

References

[1] https://en.wikipedia.org/wiki/Prasterone

Also known as ATC code A14AA07, ATCvet code QA14AA07, DHEA (dietary supplement), DHEA (medication), DHEA (nutritional supplement), DHEA (supplement), Dehydroepiandrosterone (dietary supplement), Dehydroepiandrosterone (medication), Dehydroepiandrosterone (nutritional supplement), Dehydroepiandrosterone (supplement), EL 10, EL-10, EL10, GL 701, GL-701, GL701, Intrarosa, Prasteron, Prasterona, Prasteronum.

, Dietary supplement, Dietary Supplement Health and Education Act of 1994, Dihydrotestosterone, Drug Enforcement Administration, Drugs controlled by the UK Misuse of Drugs Act, Dyspareunia, English language, Epiandrosterone, Ester, Estradiol, Estradiol (medication), Estradiol valerate, Estrogen, Estrogen (medication), Estrogen receptor, Estrone, Estrone (medication), Etiocholanolone, Europe, Fábio Maldonado, Fluasterone, Food and Drug Administration, French language, Glucose-6-phosphate dehydrogenase, Grandfather clause, Gynecomastia, Hair follicle, Headache, Health Canada, High-density lipoprotein, Hirsutism, Hormone replacement therapy, Human skin, Hydrocortisone, Injection (medicine), Insomnia, International nonproprietary name, International Tennis Federation, Intramuscular injection, Intravaginal administration, Italian language, Japan, Ketosteroid, King Features Syndicate, LaShawn Merritt, Latin, Libido, Liver, Lupus, Mechanism of action, Medication, Metabolism, Micronization, Mixed martial arts, Nandrolone, National Basketball Association, Natural product, Neurosteroid, New Drug Application, New Zealand, Nor-, O. J. Mayo, Oral administration, Over-the-counter drug, Pharmacodynamics, Polycystic ovary syndrome, Prasterone enanthate, Prasterone sulfate, Print syndication, Prodrug, Prohormone, Prostate, Prostate cancer, Reaction intermediate, Rectal administration, Salt (chemistry), Sexual desire, Side effect, Signs and symptoms, Skin, Sodium, Steroid, Steroid hormone, Steroid sulfatase, Steroid sulfotransferase, Stroke, Structural analog, Structural isomer, Sulfate, SULT1E1, Suppository, Tablet (pharmacy), Tamoxifen, Testosterone, Testosterone (medication), Tissue (biology), Tissue selectivity, Trademark distinctiveness, Transdermal, Ultimate Fighting Championship, United Kingdom, United States, United States Adopted Name, Urine, Uterine cancer, Vagina, Venus Williams, Virilization, Voice change, Volume of distribution, Weight loss, World Anti-Doping Agency, Yuliya Yefimova, 1-Androsterone, 1-Testosterone, 17β-Hydroxysteroid dehydrogenase, 19-Nordehydroepiandrosterone, 3β-Hydroxysteroid dehydrogenase, 4-Dehydroepiandrosterone, 5α-Reductase.

Prasterone, the Glossary

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