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Quetiapine, the Glossary

Quetiapine, sold under the brand name Seroquel among others, is an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.^[1]

192 relations: Active metabolite, Adrenergic antagonist, Agranulocytosis, Alpha blocker, Alpha-1 adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-2 adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor, Alzheimer's disease, Anaphylaxis, Anticholinergic, Antihistamine, Antipsychotic, Anxiety disorder, Aripiprazole, Asenapine, AstraZeneca, Atypical antipsychotic, Autoreceptor, BBC News, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Biological half-life, Biovail, Bipolar disorder, Bipolar I disorder, Bloomberg L.P., British National Formulary, Bupropion, Cardiac arrest, Cardiomyopathy, Chlorpromazine, Clozapine, Cocaine, Cognition, Complete blood count, Constipation, Death of Dan Markingson, Dementia, Diabetes, Diabetic ketoacidosis, Diário Oficial da União, Dibenzothiazepine, Dopamine antagonist, Dopamine receptor, Dopamine receptor D1, Dopamine receptor D2, ... Expand index (142 more) »
Atypical antipsychotics
Dibenzothiazepines
Glycol ethers
Mood stabilizers

An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical.

See Quetiapine and Active metabolite

Adrenergic antagonist

An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors.

See Quetiapine and Adrenergic antagonist

Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood.

See Quetiapine and Agranulocytosis

Alpha blocker

Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).

See Quetiapine and Alpha blocker

Alpha-1 adrenergic receptor

alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein.

See Quetiapine and Alpha-1 adrenergic receptor

Alpha-1A adrenergic receptor

The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

See Quetiapine and Alpha-1A adrenergic receptor

Alpha-1B adrenergic receptor

The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

See Quetiapine and Alpha-1B adrenergic receptor

Alpha-2 adrenergic receptor

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.

See Quetiapine and Alpha-2 adrenergic receptor

Alpha-2A adrenergic receptor

The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.

See Quetiapine and Alpha-2A adrenergic receptor

Alpha-2B adrenergic receptor

The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor.

See Quetiapine and Alpha-2B adrenergic receptor

Alpha-2C adrenergic receptor

The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

See Quetiapine and Alpha-2C adrenergic receptor

Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia.

See Quetiapine and Alzheimer's disease

Anaphylaxis

Anaphylaxis (Greek: ana- ‘against’ + phylaxis ‘guarding’) is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of the use of emergency medication on site.

See Quetiapine and Anaphylaxis

Anticholinergic

Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central and peripheral nervous system.

See Quetiapine and Anticholinergic

Antihistamine

Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies.

See Quetiapine and Antihistamine

Antipsychotic

Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders.

See Quetiapine and Antipsychotic

Anxiety disorder

Anxiety disorders are a group of mental disorders characterized by significant and uncontrollable feelings of anxiety and fear such that a person's social, occupational, and personal functions are significantly impaired.

See Quetiapine and Anxiety disorder

Aripiprazole

Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder; other uses include as an add-on treatment in major depressive disorder and obsessive compulsive disorder (OCD), tic disorders, and irritability associated with autism. Quetiapine and Aripiprazole are 5-HT2A antagonists, alpha-1 blockers, alpha-2 blockers, atypical antipsychotics, Ethers and mood stabilizers.

See Quetiapine and Aripiprazole

Asenapine

Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder. Quetiapine and Asenapine are alpha-2 blockers and atypical antipsychotics.

See Quetiapine and Asenapine

AstraZeneca

AstraZeneca plc (AZ) is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge, England.

See Quetiapine and AstraZeneca

Atypical antipsychotic

The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric conditions. Quetiapine and atypical antipsychotic are atypical antipsychotics.

See Quetiapine and Atypical antipsychotic

Autoreceptor

An autoreceptor is a type of receptor located in the membranes of nerve cells.

See Quetiapine and Autoreceptor

BBC News

BBC News is an operational business division of the British Broadcasting Corporation (BBC) responsible for the gathering and broadcasting of news and current affairs in the UK and around the world.

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Beta-1 adrenergic receptor

The beta-1 adrenergic receptor (β1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors.

See Quetiapine and Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation.

See Quetiapine and Beta-2 adrenergic receptor

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

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Biovail

Biovail Corporation was a Canadian pharmaceutical company, operating internationally in all aspects of pharmaceutical products.

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Bipolar disorder

Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that each last from days to weeks.

See Quetiapine and Bipolar disorder

Bipolar I disorder

Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features.

See Quetiapine and Bipolar I disorder

Bloomberg L.P.

Bloomberg L.P. is a privately held financial, software, data, and media company headquartered in Midtown Manhattan, New York City.

See Quetiapine and Bloomberg L.P.

British National Formulary

The British National Formulary (BNF) is a United Kingdom (UK) pharmaceutical reference book that contains a wide spectrum of information and advice on prescribing and pharmacology, along with specific facts and details about many medicines available on the UK National Health Service (NHS).

See Quetiapine and British National Formulary

Bupropion

Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Quetiapine and Bupropion are antidepressants and world Health Organization essential medicines.

See Quetiapine and Bupropion

Cardiac arrest

Cardiac arrest, also known as sudden cardiac arrest, is when the heart suddenly and unexpectedly stops beating.

See Quetiapine and Cardiac arrest

Cardiomyopathy

Cardiomyopathy is a group of primary diseases of the heart muscle.

See Quetiapine and Cardiomyopathy

Chlorpromazine

Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. Quetiapine and Chlorpromazine are alpha-1 blockers, alpha-2 blockers and world Health Organization essential medicines.

See Quetiapine and Chlorpromazine

Clozapine

Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. Quetiapine and Clozapine are alpha-1 blockers, alpha-2 blockers, atypical antipsychotics, mood stabilizers, Piperazines and world Health Organization essential medicines.

See Quetiapine and Clozapine

Cocaine

Cocaine (from, from, ultimately from Quechua: kúka) is a tropane alkaloid that acts as a central nervous system (CNS) stimulant.

See Quetiapine and Cocaine

Cognition

Cognition is the "mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

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Complete blood count

A complete blood count (CBC), also known as a full blood count (FBC), is a set of medical laboratory tests that provide information about the cells in a person's blood.

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Constipation

Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.

See Quetiapine and Constipation

Death of Dan Markingson

Dan Markingson (November 25, 1976–May 8, 2004) was a man from St.

See Quetiapine and Death of Dan Markingson

Dementia

Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform everyday activities.

See Quetiapine and Dementia

Diabetes

Diabetes mellitus, often known simply as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels.

See Quetiapine and Diabetes

Diabetic ketoacidosis

Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus.

See Quetiapine and Diabetic ketoacidosis

Diário Oficial da União

The Diário Oficial da União (literally Official Diary of the Union), abbreviated DOU, is the official journal of the federal government of Brazil.

See Quetiapine and Diário Oficial da União

Dibenzothiazepine

Dibenzothiazepines are chemical compounds which are derivatives of thiazepine with two benzene rings. Quetiapine and Dibenzothiazepine are Dibenzothiazepines.

See Quetiapine and Dibenzothiazepine

Dopamine antagonist

A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by receptor antagonism.

See Quetiapine and Dopamine antagonist

Dopamine receptor

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).

See Quetiapine and Dopamine receptor

Dopamine receptor D1

Dopamine receptor D1, also known as DRD1.

See Quetiapine and Dopamine receptor D1

Dopamine receptor D2

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.

See Quetiapine and Dopamine receptor D2

Dopamine receptor D3

Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.

See Quetiapine and Dopamine receptor D3

Dopamine receptor D4

The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.

See Quetiapine and Dopamine receptor D4

Dopamine receptor D5

Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.

See Quetiapine and Dopamine receptor D5

Dyslipidemia

Dyslipidemia is a metabolic disorder characterized by abnormally high or low amounts of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood.

See Quetiapine and Dyslipidemia

Dysphagia

Dysphagia is difficulty in swallowing.

See Quetiapine and Dysphagia

Edema

Edema (AmE), also spelled oedema (BrE), and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's tissue.

See Quetiapine and Edema

Effect size

In statistics, an effect size is a value measuring the strength of the relationship between two variables in a population, or a sample-based estimate of that quantity.

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Electrocardiography

Electrocardiography is the process of producing an electrocardiogram (ECG or EKG), a recording of the heart's electrical activity through repeated cardiac cycles.

See Quetiapine and Electrocardiography

Eosinophilia

Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds.

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Excretion

Excretion is elimination of metabolic waste, which is an essential process in all organisms.

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Extrapyramidal symptoms (EPS) are symptoms that are archetypically associated with the extrapyramidal system of the brain's cerebral cortex.

See Quetiapine and Extrapyramidal symptoms

Feces

Feces (or faeces;: faex) are the solid or semi-solid remains of food that was not digested in the small intestine, and has been broken down by bacteria in the large intestine.

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Fluphenazine

Fluphenazine, sold under the brand name Prolixin among others, is a high-potency typical antipsychotic medication. Quetiapine and Fluphenazine are alpha-1 blockers, alpha-2 blockers, Piperazines, primary alcohols and world Health Organization essential medicines.

See Quetiapine and Fluphenazine

Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

See Quetiapine and Food and Drug Administration

Gabapentin

Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat partial seizures and neuropathic pain.

See Quetiapine and Gabapentin

Galactorrhea

Galactorrhea (also spelled galactorrhoea) (galacto- + -rrhea) or lactorrhea (lacto- + -rrhea) is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing.

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Generic drug

A generic drug (or simply generic) is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents.

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GRADE approach

The GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) is a method of assessing the certainty in evidence (also known as quality of evidence or confidence in effect estimates) and the strength of recommendations in health care.

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Gynecomastia

Gynecomastia (also spelled gynaecomastia) is the abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens.

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Haloperidol

Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Quetiapine and Haloperidol are world Health Organization essential medicines.

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Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

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Hepatitis

Hepatitis is inflammation of the liver tissue.

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Histamine H1 receptor

The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.

See Quetiapine and Histamine H1 receptor

Histamine H2 receptor

H2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals.

See Quetiapine and Histamine H2 receptor

Histamine H3 receptor

Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons and control histamine turnover by feedback inhibition of histamine synthesis and release.

See Quetiapine and Histamine H3 receptor

Histamine H4 receptor

The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the HRH4 gene.

See Quetiapine and Histamine H4 receptor

Histamine receptor

The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.

See Quetiapine and Histamine receptor

Hypercholesterolemia

Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood.

See Quetiapine and Hypercholesterolemia

Hyperglycemia

Hyperglycemia or Hyperglycaemia is a condition in which an excessive amount of glucose circulates in the blood plasma.

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Hypertension

Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Hyponatremia

Hyponatremia or hyponatraemia is a low concentration of sodium in the blood.

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Hypotension

Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure.

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Hypothyroidism

Hypothyroidism (also called underactive thyroid, low thyroid or hypothyreosis) is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormones.

See Quetiapine and Hypothyroidism

Indigestion

Indigestion, also known as dyspepsia or upset stomach, is a condition of impaired digestion.

See Quetiapine and Indigestion

Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

See Quetiapine and Insomnia

Irregular menstruation

Irregular menstruation is a menstrual disorder whose manifestations include irregular cycle lengths as well as metrorrhagia (vaginal bleeding between expected periods).

See Quetiapine and Irregular menstruation

Jaundice

Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels.

See Quetiapine and Jaundice

Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

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Lactam

A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions.

See Quetiapine and Lactam

Lamotrigine

Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. Quetiapine and Lamotrigine are mood stabilizers and world Health Organization essential medicines.

See Quetiapine and Lamotrigine

Leukopenia

Leukopenia is a decrease in the number of leukocytes (WBC).

See Quetiapine and Leukopenia

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

See Quetiapine and Ligand (biochemistry)

Lithium (medication)

Certain lithium compounds, also known as lithium salts, are used as psychiatric medication, primarily for bipolar disorder and for major depressive disorder. Quetiapine and lithium (medication) are mood stabilizers and world Health Organization essential medicines.

See Quetiapine and Lithium (medication)

Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

See Quetiapine and Liver

Loxapine

Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia. Quetiapine and Loxapine are alpha-1 blockers, alpha-2 blockers and Piperazines.

See Quetiapine and Loxapine

Lurasidone

Lurasidone, sold under the brand name Latuda among others, is an antipsychotic medication used to treat schizophrenia and bipolar disorder. Quetiapine and Lurasidone are alpha-2 blockers, atypical antipsychotics, mood stabilizers and Piperazines.

See Quetiapine and Lurasidone

Major depressive disorder

Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.

See Quetiapine and Major depressive disorder

Mania

Mania, also known as manic syndrome, is a mental and behavioral disorder defined as a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." During a manic episode, an individual will experience rapidly changing emotions and moods, highly influenced by surrounding stimuli.

See Quetiapine and Mania

Marine Corps Times

Marine Corps Times (ISSN 1522-0869) is a newspaper serving active, reserve and retired United States Marine Corps personnel and their families, providing news, information and analysis as well as community and lifestyle features, educational supplements, and resource guides.

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Mean absolute difference

The mean absolute difference (univariate) is a measure of statistical dispersion equal to the average absolute difference of two independent values drawn from a probability distribution.

See Quetiapine and Mean absolute difference

Medicines and Healthcare products Regulatory Agency

The Medicines and Healthcare products Regulatory Agency (MHRA) is an executive agency of the Department of Health and Social Care in the United Kingdom which is responsible for ensuring that medicines and medical devices work and are acceptably safe.

See Quetiapine and Medicines and Healthcare products Regulatory Agency

Mirtazapine

Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. Quetiapine and Mirtazapine are alpha-2 blockers, Piperazines and sedatives.

See Quetiapine and Mirtazapine

Modified-release dosage

Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release dosage) or to a specific target in the body (targeted-release dosage).

See Quetiapine and Modified-release dosage

Molindone

Molindone, sold under the brand name Moban, is an antipsychotic which is used in the United States in the treatment of schizophrenia.

See Quetiapine and Molindone

Movement disorder

Movement disorders are clinical syndromes with either an excess of movement or a paucity of voluntary and involuntary movements, unrelated to weakness or spasticity.

See Quetiapine and Movement disorder

Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.

See Quetiapine and Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptor M1

The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.

See Quetiapine and Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M2

The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.

See Quetiapine and Muscarinic acetylcholine receptor M2

Muscarinic acetylcholine receptor M3

The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.

See Quetiapine and Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M4

The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.

See Quetiapine and Muscarinic acetylcholine receptor M4

Muscarinic acetylcholine receptor M5

The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.

See Quetiapine and Muscarinic acetylcholine receptor M5

Muscarinic antagonist

A muscarinic receptor antagonist (MRA), also called an antimuscarinic, is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor.

See Quetiapine and Muscarinic antagonist

Musical hallucinations

Musical hallucinations (also known as auditory hallucinations, auditory Charles Bonnet Syndrome, and Oliver Sacks' syndrome) describes a neurological disorder in which the patient will hallucinate songs, tunes, instruments and melodies.

See Quetiapine and Musical hallucinations

Myocarditis

Myocarditis, also known as inflammatory cardiomyopathy, is an acquired cardiomyopathy due to inflammation of the heart muscle.

See Quetiapine and Myocarditis

Neuroleptic malignant syndrome

Neuroleptic malignant syndrome (NMS) is a rare but life-threatening reaction that can occur in response to antipsychotic (neuroleptic) medications.

See Quetiapine and Neuroleptic malignant syndrome

Neutropenia

Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.

See Quetiapine and Neutropenia

New Drug Application

The Food and Drug Administration's (FDA) New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.

See Quetiapine and New Drug Application

Nigrostriatal pathway

The nigrostriatal pathway is a bilateral dopaminergic pathway in the brain that connects the substantia nigra pars compacta (SNc) in the midbrain with the dorsal striatum (i.e., the caudate nucleus and putamen) in the forebrain.

See Quetiapine and Nigrostriatal pathway

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.

See Quetiapine and NMDA receptor

Nonbenzodiazepine

Nonbenzodiazepines, sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia and anxiety. Quetiapine and Nonbenzodiazepine are hypnotics and sedatives.

See Quetiapine and Nonbenzodiazepine

Nucleophilic substitution

In chemistry, a nucleophilic substitution (SN) is a class of chemical reactions in which an electron-rich chemical species (known as a nucleophile) replaces a functional group within another electron-deficient molecule (known as the electrophile).

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Nurofen

Nurofen is a brand name range of pain-relief medication containing ibuprofen made by the British multinational Reckitt.

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Off-label use

Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.

See Quetiapine and Off-label use

Olanzapine

Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. Quetiapine and Olanzapine are 5-HT2A antagonists, alpha-1 blockers, alpha-2 blockers, atypical antipsychotics, mood stabilizers, Piperazines and world Health Organization essential medicines.

See Quetiapine and Olanzapine

Oral administration

| name.

See Quetiapine and Oral administration

Orthostatic hypotension

Orthostatic hypotension, also known as postural hypotension, is a medical condition wherein a person's blood pressure drops when standing up or sitting down.

See Quetiapine and Orthostatic hypotension

Paliperidone

Paliperidone, sold under the brand name Invega among others, is an atypical antipsychotic. Quetiapine and Paliperidone are alpha-2 blockers, atypical antipsychotics, mood stabilizers and world Health Organization essential medicines.

See Quetiapine and Paliperidone

Pancreatitis

Pancreatitis is a condition characterized by inflammation of the pancreas.

See Quetiapine and Pancreatitis

Parkinson's disease

Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.

See Quetiapine and Parkinson's disease

Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

See Quetiapine and Partial agonist

Perphenazine

Perphenazine is a typical antipsychotic drug. Quetiapine and Perphenazine are Piperazines and primary alcohols.

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Pharmaceutical Benefits Scheme

The Pharmaceutical Benefits Scheme (PBS) is a program of the Australian Government that subsidises prescription medication for Australian citizens and permanent residents, as well as international visitors covered by a reciprocal health care agreement.

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Pharmacodynamics

Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).

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Pharyngitis

Pharyngitis is inflammation of the back of the throat, known as the pharynx.

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Phosphoryl chloride

Phosphoryl chloride (commonly called phosphorus oxychloride) is a colourless liquid with the formula.

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Pimozide

Pimozide (sold under the brand name Orap) is a neuroleptic drug of the diphenylbutylpiperidine class.

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Placebo

A placebo is a substance or treatment which is designed to have no therapeutic value.

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Plasma protein binding

Plasma protein binding refers to the degree to which medications attach to blood proteins within the blood plasma.

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Positive and Negative Syndrome Scale

The Positive and Negative Syndrome Scale (PANSS) is a medical scale used for measuring symptom severity of patients with schizophrenia.

See Quetiapine and Positive and Negative Syndrome Scale

Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).

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Priapism

Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after stimulation has ended.

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Prolactin

Prolactin (PRL), also known as lactotropin and mammotropin, is a protein best known for its role in enabling mammals to produce milk.

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QT interval

The QT interval is a measurement made on an electrocardiogram used to assess some of the electrical properties of the heart.

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Relative risk

The relative risk (RR) or risk ratio is the ratio of the probability of an outcome in an exposed group to the probability of an outcome in an unexposed group.

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Restless legs syndrome

Restless legs syndrome, also known as restless leg syndrome (RLS), also known as Willis–Ekbom disease (WED), is a neurological disorder, usually chronic, that causes an overwhelming urge to move one's legs.

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Risperidone

Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. Quetiapine and Risperidone are alpha-1 blockers, alpha-2 blockers, atypical antipsychotics, mood stabilizers and world Health Organization essential medicines.

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Schizophrenia

Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.

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Sedation

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

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Seizure

A seizure is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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Seizure threshold

The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures.

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Serotonin receptor antagonist

A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action of serotonin and serotonergic drugs at serotonin (5-HT) receptors.

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Sertindole

Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication. Quetiapine and Sertindole are atypical antipsychotics.

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Sigma-1 receptor

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.

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Sigma-2 receptor

The sigma-2 receptor (σ2R) is a sigma receptor subtype that has attracted attention due to its involvement in diseases such as neurological diseases, neurodegenerative, neuro-ophthalmic and cancer.

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Somnolence

Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

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Stevens–Johnson syndrome

Stevens–Johnson syndrome (SJS) is a type of severe skin reaction.

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Strength of evidence

In biostatistics, strength of evidence is the strength of a conducted study that can be assessed in health care interventions, e.g. to identify effective health care programs and evaluate the quality of the research in health care.

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Substance abuse

Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others.

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Suicidal ideation

Suicidal ideation, or suicidal thoughts, is the thought process of having ideas, or ruminations about the possibility of completing suicide.

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Syncope (medicine)

Syncope, commonly known as fainting or passing out, is a loss of consciousness and muscle strength characterized by a fast onset, short duration, and spontaneous recovery.

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Systematic review

A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic.

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Tachycardia

Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.

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Tardive dyskinesia

Tardive dyskinesia (TD) is a disorder that results in involuntary repetitive body movements, which may include grimacing, sticking out the tongue or smacking the lips.

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Tetracyclic

Tetracyclics are cyclic chemical compounds that contain four fused rings of atoms, for example, Tröger's base.

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The Local

The Local is a multi-regional, European, English-language digital news publisher with local editions in Austria, Denmark, France, Germany, Italy, Norway, Spain, Sweden and Switzerland.

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The Madison / St. Clair Record

The Madison / St.

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Thioridazine

Thioridazine (Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. Quetiapine and Thioridazine are alpha-1 blockers.

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Tiotixene

Tiotixene, or thiothixene is a typical antipsychotic agent currently sold under the brand name Navane which is predominantly utilised to treat acute and chronic schizophrenia. Quetiapine and Tiotixene are alpha-1 blockers and Piperazines.

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Tourette syndrome

Tourette syndrome or Tourette's syndrome (abbreviated as TS or Tourette's) is a common neurodevelopmental disorder that begins in childhood or adolescence.

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Trifluoperazine

Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia. Quetiapine and Trifluoperazine are Piperazines.

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Tuberoinfundibular pathway

The tuberoinfundibular pathway refers to a population of dopamine neurons that project from the arcuate nucleus (the "infundibular nucleus") in the tuberal region of the hypothalamus to the median eminence.

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Typical antipsychotic

Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).

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Valproate

Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. Quetiapine and valproate are mood stabilizers and world Health Organization essential medicines.

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Weakness

Weakness is a symptom of many different medical conditions.

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WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. Quetiapine and WHO Model List of Essential Medicines are world Health Organization essential medicines.

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Xerostomia

Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.

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Ziprasidone

Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. Quetiapine and Ziprasidone are atypical antipsychotics, mood stabilizers and Piperazines.

See Quetiapine and Ziprasidone

Zotepine

Zotepine is an atypical antipsychotic drug indicated for acute and chronic schizophrenia. Quetiapine and Zotepine are alpha-2 blockers and atypical antipsychotics.

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5-HT receptor

5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter.

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5-HT1B receptor

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.

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5-HT1D receptor

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.

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5-HT1E receptor

5-hydroxytryptamine (serotonin) 1E receptor (5-HT1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family (Gi-coupled serotonin receptor).

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5-HT1F receptor

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.

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5-HT2A receptor

The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

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5-HT2B receptor

5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.

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5-HT2C receptor

The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors.

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5-HT4 receptor

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.

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5-HT5A receptor

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

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5-HT6 receptor

The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).

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5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

See Quetiapine and 5-HT7 receptor

References

[1] https://en.wikipedia.org/wiki/Quetiapine

Also known as ATC code N05AH04, ATCvet code QN05AH04, Asicot, C21H25N3O2S, Ketilept, Ketipinor, Kventiax, Quepin, Quetiapin hemifumarate, Quetiapina, Quetiapine Fumarate, Quetiapinum, Quietipine, SEROQUEL XR, Sequase, Seraquel, Seroquel, Seroquel Prolong, Seroquel SR, Seroquel withdrawl, Seroquil, Snoozeberries, Special Q, Tevatiapine XR, Xeroquel.

, Dopamine receptor D3, Dopamine receptor D4, Dopamine receptor D5, Dyslipidemia, Dysphagia, Edema, Effect size, Electrocardiography, Eosinophilia, Excretion, Extrapyramidal symptoms, Feces, Fluphenazine, Food and Drug Administration, Gabapentin, Galactorrhea, Generic drug, GRADE approach, Gynecomastia, Haloperidol, Health Canada, Hepatitis, Histamine H1 receptor, Histamine H2 receptor, Histamine H3 receptor, Histamine H4 receptor, Histamine receptor, Hypercholesterolemia, Hyperglycemia, Hypertension, Hyponatremia, Hypotension, Hypothyroidism, Indigestion, Insomnia, Irregular menstruation, Jaundice, Kidney, Lactam, Lamotrigine, Leukopenia, Ligand (biochemistry), Lithium (medication), Liver, Loxapine, Lurasidone, Major depressive disorder, Mania, Marine Corps Times, Mean absolute difference, Medicines and Healthcare products Regulatory Agency, Mirtazapine, Modified-release dosage, Molindone, Movement disorder, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Muscarinic antagonist, Musical hallucinations, Myocarditis, Neuroleptic malignant syndrome, Neutropenia, New Drug Application, Nigrostriatal pathway, NMDA receptor, Nonbenzodiazepine, Nucleophilic substitution, Nurofen, Off-label use, Olanzapine, Oral administration, Orthostatic hypotension, Paliperidone, Pancreatitis, Parkinson's disease, Partial agonist, Perphenazine, Pharmaceutical Benefits Scheme, Pharmacodynamics, Pharyngitis, Phosphoryl chloride, Pimozide, Placebo, Plasma protein binding, Positive and Negative Syndrome Scale, Pregnancy, Priapism, Prolactin, QT interval, Relative risk, Restless legs syndrome, Risperidone, Schizophrenia, Sedation, Seizure, Seizure threshold, Serotonin receptor antagonist, Sertindole, Sigma-1 receptor, Sigma-2 receptor, Somnolence, Stevens–Johnson syndrome, Strength of evidence, Substance abuse, Suicidal ideation, Syncope (medicine), Systematic review, Tachycardia, Tardive dyskinesia, Tetracyclic, The Local, The Madison / St. Clair Record, Thioridazine, Tiotixene, Tourette syndrome, Trifluoperazine, Tuberoinfundibular pathway, Typical antipsychotic, Valproate, Weakness, WHO Model List of Essential Medicines, Xerostomia, Ziprasidone, Zotepine, 5-HT receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT1F receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT4 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor.

Quetiapine, the Glossary

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