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Short hairpin RNA, the Glossary

Index Short hairpin RNA

A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).[1]

Table of Contents

  1. 19 relations: Adeno-associated virus, Adenoviridae, Dicer, Drosha, Escherichia coli, Expression vector, Gene expression, Lentivirus, Plasmid, Promoter (genetics), RNA, RNA interference, RNA polymerase II, RNA polymerase III, RNA-induced silencing complex, Small interfering RNA, Vector (molecular biology), VIRsiRNAdb, Wiskott–Aldrich syndrome.

  2. RNA interference

Adeno-associated virus

Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species.

See Short hairpin RNA and Adeno-associated virus

Adenoviridae

Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome.

See Short hairpin RNA and Adenoviridae

Dicer

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the gene. Short hairpin RNA and Dicer are RNA interference.

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Drosha

Drosha is a Class 2 ribonuclease III enzyme that in humans is encoded by the DROSHA (formerly RNASEN) gene. Short hairpin RNA and Drosha are RNA interference.

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Escherichia coli

Escherichia coliWells, J. C. (2000) Longman Pronunciation Dictionary.

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Expression vector

An expression vector, otherwise known as an expression construct, is usually a plasmid or virus designed for gene expression in cells.

See Short hairpin RNA and Expression vector

Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype.

See Short hairpin RNA and Gene expression

Lentivirus

Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species.

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Plasmid

A plasmid is a small, extrachromosomal DNA molecule within a cell that is physically separated from chromosomal DNA and can replicate independently.

See Short hairpin RNA and Plasmid

In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter.

See Short hairpin RNA and Promoter (genetics)

RNA

Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA).

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RNA interference

RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Short hairpin RNA and RNA interference are RNA.

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RNA polymerase II

RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA.

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RNA polymerase III

In eukaryote cells, RNA polymerase III (also called Pol III) is a protein that transcribes DNA to synthesize 5S ribosomal RNA, tRNA, and other small RNAs.

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RNA-induced silencing complex

The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which functions in gene silencing via a variety of pathways at the transcriptional and translational levels. Short hairpin RNA and RNA-induced silencing complex are RNA.

See Short hairpin RNA and RNA-induced silencing complex

Small interfering RNA

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20–24 (normally 21) base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. Short hairpin RNA and Small interfering RNA are RNA and RNA interference.

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Vector (molecular biology)

In molecular cloning, a vector is any particle (e.g., plasmids, cosmids, Lambda phages) used as a vehicle to artificially carry a foreign nucleic sequence – usually DNA – into another cell, where it can be replicated and/or expressed.

See Short hairpin RNA and Vector (molecular biology)

VIRsiRNAdb

VIRsiRNAdb is a database of siRNA/shRNA targeting viral genome regions. Short hairpin RNA and VIRsiRNAdb are RNA and RNA interference.

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Wiskott–Aldrich syndrome

Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia (low platelet count), immune deficiency, and bloody diarrhea (secondary to the thrombocytopenia). It is also sometimes called the eczema-thrombocytopenia-immunodeficiency syndrome in keeping with Aldrich's original description in 1954.

See Short hairpin RNA and Wiskott–Aldrich syndrome

See also

RNA interference

References

[1] https://en.wikipedia.org/wiki/Short_hairpin_RNA

Also known as Hairpin RNA, HpRNA, ShRNA, Small hairpin RNA.