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Solifenacin, the Glossary

Solifenacin, sold as the brand name Vesicare among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO).^[1]

60 relations: Acetylcholine, Acetylcholine receptor, Active metabolite, Adverse drug reaction, Amine oxide, Anaphylaxis, Anticholinergic, Aromaticity, Arrhythmia, Astellas Pharma, Atropine, Biological half-life, Bladder, Carboxylic acid, Child–Pugh score, Cost-effectiveness analysis, CYP3A4, Cytochrome P450, Darifenacin, Drug-induced QT prolongation, Enzyme inhibitor, Ester, Food and Drug Administration, Frequent urination, Glaucoma, Glucuronide, GSK plc, Hallucination, Hemodialysis, HERG, Hyperthermia, Ketoconazole, Kidney, Long QT syndrome, Merck Index, Merck Manual of Diagnosis and Therapy, Moxifloxacin, Muscarinic acetylcholine receptor M3, Muscarinic antagonist, Muscle tone, Oral administration, Overactive bladder, Oxybutynin, Perspiration, Pimozide, Plasma protein, Pregnancy, QT interval, Quinuclidine, Receptor antagonist, ... Expand index (10 more) »
3-Quinuclidinyl esters
Astellas Pharma
Tetrahydroisoquinolines

Acetylcholine

Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter.

See Solifenacin and Acetylcholine

Acetylcholine receptor

An acetylcholine receptor (abbreviated AChR) or a cholinergic receptor is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.

See Solifenacin and Acetylcholine receptor

An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical.

See Solifenacin and Active metabolite

Adverse drug reaction

An adverse drug reaction (ADR) is a harmful, unintended result caused by taking medication.

See Solifenacin and Adverse drug reaction

Amine oxide

In chemistry, an amine oxide, also known as an amine N-oxide or simply N-oxide, is a chemical compound that has the chemical formula.

See Solifenacin and Amine oxide

Anaphylaxis (Greek: ana- ‘against’ + phylaxis ‘guarding’) is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of the use of emergency medication on site.

See Solifenacin and Anaphylaxis

Anticholinergic

Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central and peripheral nervous system.

See Solifenacin and Anticholinergic

Aromaticity

In organic chemistry, aromaticity is a chemical property describing the way in which a conjugated ring of unsaturated bonds, lone pairs, or empty orbitals exhibits a stabilization stronger than would be expected by the stabilization of conjugation alone.

See Solifenacin and Aromaticity

Arrhythmia

Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow.

See Solifenacin and Arrhythmia

Astellas Pharma

is a Japanese multinational pharmaceutical company, formed on 1 April 2005 from the merger of and.

See Solifenacin and Astellas Pharma

Atropine

Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. Solifenacin and Atropine are muscarinic antagonists.

See Solifenacin and Atropine

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Solifenacin and Biological half-life

Bladder

The bladder is a hollow organ in humans and other vertebrates that stores urine from the kidneys before disposal by urination.

See Solifenacin and Bladder

Carboxylic acid

In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group attached to an R-group.

See Solifenacin and Carboxylic acid

Child–Pugh score

In medicine, specifically gastroenterology, the Child–Pugh score (or the Child–Turcotte–Pugh (CTP) score or Child Criteria) is used to assess the prognosis of chronic liver disease, mainly cirrhosis.

See Solifenacin and Child–Pugh score

Cost-effectiveness analysis

Cost-effectiveness analysis (CEA) is a form of economic analysis that compares the relative costs and outcomes (effects) of different courses of action.

See Solifenacin and Cost-effectiveness analysis

CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene.

See Solifenacin and CYP3A4

Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.

See Solifenacin and Cytochrome P450

Darifenacin

Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. Solifenacin and Darifenacin are muscarinic antagonists.

See Solifenacin and Darifenacin

Drug-induced QT prolongation

QT prolongation is a measure of delayed ventricular repolarisation, which means the heart muscle takes longer than normal to recharge between beats.

See Solifenacin and Drug-induced QT prolongation

Enzyme inhibitor

An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.

See Solifenacin and Enzyme inhibitor

Ester

In chemistry, an ester is a functional group derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group of that acid is replaced by an organyl group.

See Solifenacin and Ester

Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

See Solifenacin and Food and Drug Administration

Frequent urination

Frequent urination, or urinary frequency (sometimes called pollakiuria), is the need to urinate more often than usual.

See Solifenacin and Frequent urination

Glaucoma

Glaucoma is a group of eye diseases that lead to damage of the optic nerve, which transmits visual information from the eye to the brain.

See Solifenacin and Glaucoma

Glucuronide

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.

See Solifenacin and Glucuronide

GSK plc

GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British multinational pharmaceutical and biotechnology company with global headquarters in London.

See Solifenacin and GSK plc

Hallucination

A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality.

See Solifenacin and Hallucination

Hemodialysis

Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of filtering the blood of a person whose kidneys are not working normally.

See Solifenacin and Hemodialysis

HERG

hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel.

See Solifenacin and HERG

Hyperthermia

Hyperthermia, also known simply as overheating, is a condition in which an individual's body temperature is elevated beyond normal due to failed thermoregulation.

See Solifenacin and Hyperthermia

Ketoconazole

Ketoconazole, sold under the brand name Nizoral among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections.

See Solifenacin and Ketoconazole

Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

See Solifenacin and Kidney

Long QT syndrome

Long QT syndrome (LQTS) is a condition affecting repolarization (relaxing) of the heart after a heartbeat, giving rise to an abnormally lengthy QT interval.

See Solifenacin and Long QT syndrome

Merck Index

The Merck Index is an encyclopedia of chemicals, drugs and biologicals with over 10,000 monographs on single substances or groups of related compounds published online by the Royal Society of Chemistry.

See Solifenacin and Merck Index

Merck Manual of Diagnosis and Therapy

The Merck Manual of Diagnosis and Therapy, referred to as The Merck Manual, is the world's best-selling medical textbook, and the oldest continuously published English language medical textbook.

See Solifenacin and Merck Manual of Diagnosis and Therapy

Moxifloxacin

Moxifloxacin is an antibiotic, used to treat bacterial infections, including pneumonia, conjunctivitis, endocarditis, tuberculosis, and sinusitis.

See Solifenacin and Moxifloxacin

Muscarinic acetylcholine receptor M3

The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.

See Solifenacin and Muscarinic acetylcholine receptor M3

Muscarinic antagonist

A muscarinic receptor antagonist (MRA), also called an antimuscarinic, is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor. Solifenacin and muscarinic antagonist are muscarinic antagonists.

See Solifenacin and Muscarinic antagonist

Muscle tone

In physiology, medicine, and anatomy, muscle tone (residual muscle tension or tonus) is the continuous and passive partial contraction of the muscles, or the muscle's resistance to passive stretch during resting state.

See Solifenacin and Muscle tone

Oral administration

| name.

See Solifenacin and Oral administration

Overactive bladder

Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life.

See Solifenacin and Overactive bladder

Oxybutynin

Oxybutynin, sold under the brand name Ditropan among others, is an anticholinergic medication primarily used to treat overactive bladder. Solifenacin and Oxybutynin are muscarinic antagonists.

See Solifenacin and Oxybutynin

Perspiration

Perspiration, also known as sweat, is the fluid secreted by sweat glands in the skin of mammals.

See Solifenacin and Perspiration

Pimozide

Pimozide (sold under the brand name Orap) is a neuroleptic drug of the diphenylbutylpiperidine class.

See Solifenacin and Pimozide

Plasma protein

Plasma proteins, sometimes referred to as blood proteins, are proteins present in blood plasma.

See Solifenacin and Plasma protein

Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).

See Solifenacin and Pregnancy

QT interval

The QT interval is a measurement made on an electrocardiogram used to assess some of the electrical properties of the heart.

See Solifenacin and QT interval

Quinuclidine

Quinuclidine is an organic compound with the formula.

See Solifenacin and Quinuclidine

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

See Solifenacin and Receptor antagonist

Smooth muscle

Smooth (soft) muscle is one of the three major types of vertebrate muscle tissue, the other being skeletal and cardiac muscle.

See Solifenacin and Smooth muscle

Succinic acid

Succinic acid is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2.

See Solifenacin and Succinic acid

Teva Pharmaceuticals

Teva Pharmaceutical Industries Ltd. (also known as Teva Pharmaceuticals) is an Israeli multinational pharmaceutical company.

See Solifenacin and Teva Pharmaceuticals

Tolterodine

Tolterodine, sold under the brand name Detrol among others, is a medication used to treat frequent urination, urinary incontinence, or urinary urgency. Solifenacin and Tolterodine are muscarinic antagonists.

See Solifenacin and Tolterodine

Tropane

Tropane is a nitrogenous bicyclic organic compound.

See Solifenacin and Tropane

Urinary incontinence

Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine.

See Solifenacin and Urinary incontinence

Urinary retention

Urinary retention is an inability to completely empty the bladder.

See Solifenacin and Urinary retention

Urinary tract infection

A urinary tract infection (UTI) is an infection that affects a part of the urinary tract.

See Solifenacin and Urinary tract infection

Urination

Urination is the release of urine from the bladder to the outside of the body.

See Solifenacin and Urination

Xerostomia

Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.

See Solifenacin and Xerostomia

References

[1] https://en.wikipedia.org/wiki/Solifenacin

Also known as ATC code G04BD08, ATCvet code QG04BD08, Solifenacin Succinate, Vesicare, Vesicare LS, Vesikur.

, Smooth muscle, Succinic acid, Teva Pharmaceuticals, Tolterodine, Tropane, Urinary incontinence, Urinary retention, Urinary tract infection, Urination, Xerostomia.

Solifenacin, the Glossary

Table of Contents

See also

3-Quinuclidinyl esters

Astellas Pharma

Tetrahydroisoquinolines

References