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Taccalonolide, the Glossary

Taccalonolides are a class of microtubule-stabilizing agents isolated from Tacca chantrieri that has been shown to have selective cancer-fighting properties.^[1]

36 relations: ABC transporter, Apoptosis, Bcl-2, Binding site, Breast cancer, Cancer, Cell nucleus, Chemical synthesis, Cyclic flower, Docetaxel, Doxorubicin, Epothilone, Epoxide, In vitro, In vivo, Interphase, Lactone, Lung cancer, Micronucleus, Microtubule, Mitogen-activated protein kinase, Mitosis, Molecular encapsulation, Multiple drug resistance, Ovarian cancer, P-glycoprotein, Paclitaxel, Phosphorylation, Prostate cancer, Spindle apparatus, Steroid, Tacca chantrieri, Tacca leontopetaloides, Taxane, Tubulin, Vinblastine.
Microtubule inhibitors

ABC transporter

The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the oldest gene families.

See Taccalonolide and ABC transporter

Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.

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Bcl-2

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins.

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Binding site

In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity.

See Taccalonolide and Binding site

Breast cancer

Breast cancer is a cancer that develops from breast tissue.

See Taccalonolide and Breast cancer

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

See Taccalonolide and Cancer

Cell nucleus

The cell nucleus (nuclei) is a membrane-bound organelle found in eukaryotic cells.

See Taccalonolide and Cell nucleus

Chemical synthesis

Chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products.

See Taccalonolide and Chemical synthesis

Cyclic flower

A cyclic flower is a flower type formed out of a series of whorls; sets of identical organs attached around the axis at the same point.

See Taccalonolide and Cyclic flower

Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. Taccalonolide and Docetaxel are Microtubule inhibitors.

See Taccalonolide and Docetaxel

Doxorubicin

Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer.

See Taccalonolide and Doxorubicin

Epothilone

Epothilones are a class of potential cancer drugs.

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Epoxide

In organic chemistry, an epoxide is a cyclic ether, where the ether forms a three-atom ring: two atoms of carbon and one atom of oxygen.

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In vitro

In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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Interphase

Interphase is the active portion of the cell cycle that includes the G1, S, and G2 phases, where the cell grows, replicates its DNA, and prepares for mitosis, respectively.

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Lactone

Lactones are cyclic carboxylic esters.

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Lung cancer

Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung.

See Taccalonolide and Lung cancer

Micronucleus

A micronucleus is a small nucleus that forms whenever a chromosome or a fragment of a chromosome is not incorporated into one of the daughter nuclei during cell division.

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Microtubule

Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells.

See Taccalonolide and Microtubule

Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines.

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Mitosis

Mitosis is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei.

See Taccalonolide and Mitosis

Molecular encapsulation

In supramolecular chemistry, molecular encapsulation is the confinement of a guest molecule inside the cavity of a supramolecular host molecule (molecular capsule, molecular container or cage compounds).

See Taccalonolide and Molecular encapsulation

Multiple drug resistance

Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories.

See Taccalonolide and Multiple drug resistance

Ovarian cancer

Ovarian cancer is a cancerous tumor of an ovary.

See Taccalonolide and Ovarian cancer

P-glycoprotein

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.

See Taccalonolide and P-glycoprotein

Paclitaxel

Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. Taccalonolide and Paclitaxel are Microtubule inhibitors.

See Taccalonolide and Paclitaxel

References

[1] https://en.wikipedia.org/wiki/Taccalonolide

Also known as Taccalin.

Taccalonolide, the Glossary

Table of Contents

See also

Microtubule inhibitors

References