Thiocoraline, the Glossary
Thiocoraline is a microbial natural product of the depsipeptide class. Thiocoraline was isolated from the mycelium cake of a marine actinomycete strain L-13-ACM2-092. In vitro, thiocoraline causes an arrest in G1 phase of the cell cycle and decreases the rate of S phase progression towards G2/M phase.[1]
Table of Contents
12 relations: Actinomycetales, Cell cycle, Depsipeptide, DNA replication, Enzyme inhibitor, G1 phase, In vitro, Microorganism, Mycelium, Natural product, Nonribosomal peptide, S phase.
- Depsipeptides
Actinomycetales
The Actinomycetales is an order of Actinomycetota.
See Thiocoraline and Actinomycetales
Cell cycle
The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell that causes it to divide into two daughter cells.
See Thiocoraline and Cell cycle
Depsipeptide
A depsipeptide is a peptide in which one or more of its amide, -C(O)NHR-, groups are replaced by the corresponding ester, -C(O)OR-. Thiocoraline and depsipeptide are depsipeptides.
See Thiocoraline and Depsipeptide
DNA replication
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.
See Thiocoraline and DNA replication
Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.
See Thiocoraline and Enzyme inhibitor
G1 phase
The G1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.
In vitro
In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
Microorganism
A microorganism, or microbe, is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from sixth century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek.
See Thiocoraline and Microorganism
Mycelium
Mycelium (mycelia) is a root-like structure of a fungus consisting of a mass of branching, thread-like hyphae.
Natural product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature.
See Thiocoraline and Natural product
Nonribosomal peptide
Nonribosomal peptides (NRP) are a class of peptide secondary metabolites, usually produced by microorganisms like bacteria and fungi.
See Thiocoraline and Nonribosomal peptide
S phase
S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.
See also
Depsipeptides
- Ambobactin
- Aurantimycin A
- Bacillibactin
- Beauvericin
- Callipeltin
- Cereulide
- Coibamide A
- Dactinomycin
- Daptomycin
- Depsipeptide
- Didemnin
- Emodepside
- Enniatin
- Fusafungine
- Gallinamide A
- Katanosin
- Keanumycin
- Kettapeptin
- Linopristin
- Lyngbyastatins
- Mirabamide
- Neamphamide A
- Papuamide
- Petrosifungin
- Phoriospongin
- Plitidepsin
- Pristinamycin
- Romidepsin
- Spiruchostatin
- Streptogramin B
- Symplocamide A
- Thiocoraline
- Valinomycin
- Viridamide
References
[1] https://en.wikipedia.org/wiki/Thiocoraline
Also known as Thiocoraline A.