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Varenicline, the Glossary

Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation and for the treatment of dry eye disease.^[1]

50 relations: Abdominal pain, Agonist, Alpha-3 beta-4 nicotinic receptor, Alpha-4 beta-2 nicotinic receptor, Alpha-7 nicotinic receptor, Boxed warning, Buprenorphine, Bupropion, Clinical trial, Constipation, Cytisine, Cytisus, Dopamine, Dry eye syndrome, Dysgeusia, European Medicines Agency, Flatulence, Food and Drug Administration, Generic drug, Glucuronidation, Headache, Health Canada, Hexose, Indication (medicine), Insomnia, Kidney, Medication, Meta-analysis, Nasal administration, Nausea, Nicotine replacement therapy, Nicotine withdrawal, Nicotinic acetylcholine receptor, Nicotinic agonist, Nitrosamine, Nucleus accumbens, Odds ratio, Oral administration, Oyster Point Pharma, Partial agonist, Pfizer, Priority review, Smoking cessation, Structural analog, Suicidal ideation, Suicide, Systematic review, Vomiting, WHO Model List of Essential Medicines, World War II.
5-HT3 agonists
Benzazepines
Bridged heterocyclic compounds
Quinoxalines

Abdominal pain

Abdominal pain, also known as a stomach ache, is a symptom associated with both non-serious and serious medical issues.

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Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

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Alpha-3 beta-4 nicotinic receptor

The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor and the ganglion-type nicotinic receptor,Pharmacology, (Rang, Dale, Ritter & Moore,, 5th ed., Churchill Livingstone 2003) p. 138.

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Alpha-4 beta-2 nicotinic receptor

The alpha-4 beta-2 nicotinic receptor, also known as the α4β2 receptor, is a type of nicotinic acetylcholine receptor implicated in learning, consisting of α4 and β2 subunits.

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Alpha-7 nicotinic receptor

The alpha-7 nicotinic receptor, also known as the α7 receptor, is a type of nicotinic acetylcholine receptor implicated in long-term memory, consisting entirely of α7 subunits.

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Boxed warning

In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears near the beginning of the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text to emphasize it is of utmost importance.

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Buprenorphine

Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain.

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Bupropion

Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Varenicline and Bupropion are smoking cessation and World Health Organization essential medicines.

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Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.

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Constipation

Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.

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Cytisine

Cytisine, also known as baptitoxine, cytisinicline, or sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. Varenicline and cytisine are Bridged heterocyclic compounds and nicotinic agonists.

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Cytisus

Cytisus is a genus of flowering plants in the family Fabaceae, native to open sites (typically scrub and heathland) in Europe, western Asia and North Africa.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.

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Dry eye syndrome

Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes.

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Dysgeusia

Dysgeusia, also known as parageusia, is a distortion of the sense of taste.

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European Medicines Agency

The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.

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Flatulence

Flatulence is the expulsion of gas from the intestines via the anus, commonly referred to as farting.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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Generic drug

A generic drug (or simply generic) is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents.

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Glucuronidation

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

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Headache

Headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck.

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Health Canada

Health Canada (HC; Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health.

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Hexose

In chemistry, a hexose is a monosaccharide (simple sugar) with six carbon atoms.

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Indication (medicine)

In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery.

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Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

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Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

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Medication

A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Meta-analysis is the statistical combination of the results of multiple studies addressing a similar research question.

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Nasal administration

Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose.

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Nausea

Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit.

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Nicotine replacement therapy

Nicotine replacement therapy (NRT) is a medically approved way to treat people with tobacco use disorder by taking nicotine through means other than tobacco. Varenicline and nicotine replacement therapy are smoking cessation and World Health Organization essential medicines.

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Nicotine withdrawal

Nicotine withdrawal is a group of symptoms that occur in the first few weeks after stopping or decreasing use of nicotine. Varenicline and nicotine withdrawal are smoking cessation.

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Nicotinic acetylcholine receptor

Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine.

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Nicotinic agonist

A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). Varenicline and nicotinic agonist are nicotinic agonists.

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Nitrosamine

In organic chemistry, nitrosamines (or more formally N-nitrosamines) are organic compounds with the chemical structure, where R is usually an alkyl group.

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Nucleus accumbens

The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for 'nucleus adjacent to the septum') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.

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Odds ratio

An odds ratio (OR) is a statistic that quantifies the strength of the association between two events, A and B. The odds ratio is defined as the ratio of the odds of event A taking place in the presence of B, the and odds of A in the absence of B. Due to symmetry, odds ratio reciprocally calculates the ratio of the odds of B occurring in the presence of A, and the odds of B in the absence of A.

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Oral administration

| name.

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Oyster Point Pharma

Oyster Point Pharma, Inc. is an American biopharmaceutical company based in Princeton, New Jersey, focusing on the development of pharmaceutical therapies to treat ophthalmic diseases.

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Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

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Pfizer

Pfizer Inc. is an American multinational pharmaceutical and biotechnology corporation headquartered at The Spiral in Manhattan, New York City.

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Priority review

Priority review is a program of the United States Food and Drug Administration (FDA) to expedite the review process for drugs that are expected to have a particularly great impact on the treatment of a disease.

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Smoking cessation

Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Suicidal ideation

Suicidal ideation, or suicidal thoughts, is the thought process of having ideas, or ruminations about the possibility of completing suicide.

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Suicide

Suicide is the act of intentionally causing one's own death.

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Systematic review

A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic.

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Vomiting

Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.

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WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. Varenicline and WHO Model List of Essential Medicines are World Health Organization essential medicines.

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World War II

World War II or the Second World War (1 September 1939 – 2 September 1945) was a global conflict between two alliances: the Allies and the Axis powers.

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References

[1] https://en.wikipedia.org/wiki/Varenicline

Also known as ATC code N07BA03, ATCvet code QN07BA03, C13H13N3, Champix, Chantix, Smoking pill, Tyrvaya, Varenicline tartrate.

Varenicline, the Glossary

Table of Contents

See also

5-HT3 agonists

Benzazepines

Bridged heterocyclic compounds

Quinoxalines

References