Air Guyane SP was a French Guianan regional airline with its head office on the grounds of Cayenne-Rochambeau Airport in Matoury.^[2] It operates regional scheduled flights. Its main base is Cayenne-Rochambeau Airport.^[3]

On June 1, 2002, Air Guyane Express began operations after taking over the former airline Air Guyane operations.^{[citation needed]} It also operates in the French Antilles with 2 ATR 42 aircraft on routes between Fort-de-France, Pointe-à-Pitre, Saint Martin and Sainte Lucie under the brand Air Antilles Express.

The airline was placed into liquidation by the Mixed Commercial Court of Pointe-à-Pitre on August 2, 2023,^[4] and it was folded on October 1 of the same year.^[1]

By April 2023, Air Guyane Express operated scheduled passenger flights to the following destinations:^[5]

Cayenne – Cayenne-Rochambeau Airport Hub
Grand Santi – Grand Santi Airport
Maripasoula – Maripasoula Airport
Saint-Laurent du Maroni – Saint-Laurent du Maroni Airport
Saül – Saül Airport

Air Guyane consisted of the following aircraft (as of April 2023).:

Air Guyane fleet

Aircraft	In service	Orders	Passengers	Notes
Let L-410 Turbolet	2	—	19	small
Total	2	—

The aircraft previously operated the following aircraft:

1 ATR 42-300 (operated by Air Antilles)
3 ATR 42-500 (2 operated by Air Antilles)
1 Britten-Norman Islander
2 De Havilland Canada DHC-6 Twin Otter
1 Reims-Cessna F406 Caravan II

^ ^a ^b Thierry Vigoureux (4 October 2023). "Air Antilles préservée mais Air Guyane liquidée". Lepoint.fr (in French).
^ "Directory: World airlines." Flight International. 20–30 March 2004. 65. "Aeroport de Cayenne, Matoury, 97351, French Guiana"
^ Flight International 27 March 2007
^ "Air Guyane Express". Centreforaviation.com.
^ Air Guyane Express

Official website (in French)