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CHRNB4 - Wikipedia

From Wikipedia, the free encyclopedia

CHRNB4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2ASG

Identifiers

Aliases

CHRNB4, cholinergic receptor nicotinic beta 4 subunit

External IDs

OMIM: 118509; MGI: 87892; HomoloGene: 20196; GeneCards: CHRNB4; OMA:CHRNB4 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q25.1	Start	78,624,111 bp^[1]
End	78,727,754 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 B	Start	54,935,438 bp^[2]
End	54,956,063 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

testicle

right testis

left testis

ganglionic eminence

muscle layer of sigmoid colon

ventricular zone

sural nerve

right adrenal gland

appendix

Top expressed in

habenula

lumbar spinal ganglion

pineal gland

ciliary body

pretectal area

iris

Paneth cell

embryo

adrenal gland

carotid body

More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	acetylcholine binding acetylcholine receptor activity ion channel activity ligand-gated ion channel activity protein heterodimerization activity extracellular ligand-gated ion channel activity protein binding acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component	acetylcholine-gated channel complex integral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction neuron projection specific granule membrane tertiary granule membrane cholinergic synapse
Biological process	smooth muscle contraction locomotory behavior regulation of smooth muscle contraction protein heterooligomerization positive regulation of transmission of nerve impulse regulation of membrane potential response to nicotine synaptic transmission, cholinergic ion transport regulation of neurotransmitter secretion behavioral response to nicotine synaptic transmission involved in micturition action potential signal transduction neutrophil degranulation regulation of postsynaptic membrane potential excitatory postsynaptic potential ion transmembrane transport chemical synaptic transmission neuromuscular synaptic transmission nervous system process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1143


108015

Ensembl


ENSG00000117971


ENSMUSG00000035200

UniProt


P30926


Q8R493

RefSeq (mRNA)


NM_000750 NM_001256567


NM_148944

RefSeq (protein)


NP_000741 NP_001243496


NP_683746

Location (UCSC)

Chr 15: 78.62 – 78.73 Mb

Chr 9: 54.94 – 54.96 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.^[5]^[6]

Interactive pathway map

[edit]

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^{[§ 1]}

[[File:

NicotineActivityonChromaffinCells_WP1603

[[]]

|alt=Nicotine Activity on Chromaffin Cells edit]]

Nicotine Activity on Chromaffin Cells edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

Nicotinic acetylcholine receptor

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117971 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035200 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–282. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
^ "Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4".

Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–287. doi:10.1016/0166-2236(95)93915-K. PMID 7571003.
Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.
Tarroni P, Rubboli F, Chini B, et al. (1992). "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines". FEBS Lett. 312 (1): 66–70. Bibcode:1992FEBSL.312...66T. doi:10.1016/0014-5793(92)81411-E. PMID 1330682.
Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–967. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
Raimondi E, Rubboli F, Moralli D, et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics. 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664.
Boulter J, O'Shea-Greenfield A, Duvoisin RM, et al. (1990). "Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster". J. Biol. Chem. 265 (8): 4472–82. doi:10.1016/S0021-9258(19)39588-2. PMID 1689727.
Papke RL, Heinemann SF (1992). "The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors". J. Physiol. 440: 95–112. doi:10.1113/jphysiol.1991.sp018698. PMC 1180142. PMID 1725184.
Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–228. doi:10.1007/BF02736842. PMID 8906617. S2CID 45737923.
Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.
Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–314. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.
Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
Gerzanich V, Kuryatov A, Anand R, Lindstrom J (1997). ""Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor". Mol. Pharmacol. 51 (2): 320–7. doi:10.1124/mol.51.2.320. PMID 9203638.
Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.
Hellström-Lindahl E, Gorbounova O, Seiger A, et al. (1998). "Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord". Brain Res. Dev. Brain Res. 108 (1–2): 147–160. doi:10.1016/S0165-3806(98)00046-7. PMID 9693793.
Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. S2CID 43548155.
Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes". J. Physiol. 529 (3): 565–77. doi:10.1111/j.1469-7793.2000.00565.x. PMC 2270211. PMID 11118490.
Lev-Lehman E, Bercovich D, Xu W, et al. (2001). "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4". J. Hum. Genet. 46 (7): 362–366. doi:10.1007/PL00010921. PMID 11450844.
Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–796. doi:10.1038/sj.bjp.0704313. PMC 1573006. PMID 11606319.

CHRNB4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CHRNB4 genome location and CHRNB4 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.