en.wikipedia.org

COX7A2 - Wikipedia

From Wikipedia, the free encyclopedia

COX7A2
Identifiers
AliasesCOX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL, cytochrome c oxidase subunit 7A2
External IDsOMIM: 123996; MGI: 1316715; HomoloGene: 36082; GeneCards: COX7A2; OMA:COX7A2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]

Chromosome 6 (human)

Genomic location for COX7A2

Genomic location for COX7A2

Band6q14.1Start75,237,675 bp[1]
End75,250,323 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]

Chromosome 9 (mouse)

Genomic location for COX7A2

Genomic location for COX7A2

Band9 E1|9 43.82 cMStart79,662,643 bp[2]
End79,667,160 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • left testis

  • right testis

  • pancreatic ductal cell

  • right ventricle

  • Brodmann area 23

  • sperm

  • apex of heart

  • primary visual cortex

  • lateral nuclear group of thalamus
Top expressed in
  • facial motor nucleus

  • medial ganglionic eminence

  • digastric muscle

  • otic placode

  • temporal muscle

  • sternocleidomastoid muscle

  • epithelium of stomach

  • triceps brachii muscle

  • intercostal muscle

  • medial vestibular nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1347

12866

Ensembl

ENSG00000112695

ENSMUSG00000032330

UniProt

P14406

P48771

RefSeq (mRNA)

NM_001865

NM_009945

RefSeq (protein)

NP_001856
NP_001353221
NP_001353222

NP_034075

Location (UCSC)Chr 6: 75.24 – 75.25 MbChr 9: 79.66 – 79.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.[5][6][7]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues.

In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112695 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032330 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.
  6. ^ Merante F, Duncan AM, Mitchell G, Duff C, Rommens J, Robinson BH (Aug 1997). "Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene". Genome. 40 (3): 318–24. doi:10.1139/g97-044. PMID 9202412.
  7. ^ a b "Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)".