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ISG20 - Wikipedia

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ISG20

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WLJ

Identifiers

Aliases

ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20

External IDs

OMIM: 604533; MGI: 1928895; HomoloGene: 31081; GeneCards: ISG20; OMA:ISG20 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q26.1	Start	88,635,670 bp^[1]
End	88,656,483 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 D2	Start	78,563,172 bp^[2]
End	78,570,144 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

spleen

blood

granulocyte

lymph node

cartilage tissue

appendix

duodenum

jejunal mucosa

epithelium of nasopharynx

right lung

Top expressed in

tibiofemoral joint

blood

spermatid

islet of Langerhans

spleen

decidua

right lung lobe

gastrula

thymus

fetal liver hematopoietic progenitor cell

More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	3'-5'-exoribonuclease activity single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity metal ion binding U3 snoRNA binding U2 snRNA binding RNA binding nucleic acid binding U1 snRNA binding nuclease activity exonuclease activity hydrolase activity
Cellular component	cytoplasm Cajal body PML body nucleoplasm nucleolus nucleus
Biological process	immune system process response to virus RNA catabolic process negative regulation of viral genome replication DNA catabolic process, exonucleolytic defense response to virus type I interferon signaling pathway rRNA processing innate immune response cell population proliferation RNA phosphodiester bond hydrolysis, exonucleolytic
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3669


57444

Ensembl


ENSG00000172183


ENSMUSG00000039236

UniProt


Q96AZ6


Q9JL16

RefSeq (mRNA)

NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237
NM_002201


NM_001113527 NM_001291220 NM_001291221 NM_020583

RefSeq (protein)

NP_001290162 NP_001290163 NP_001290164 NP_001290165 NP_001290166
NP_002192


NP_001106999 NP_001278149 NP_001278150 NP_065608

Location (UCSC)

Chr 15: 88.64 – 88.66 Mb

Chr 7: 78.56 – 78.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172183 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039236 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N (Aug 1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein". The Journal of Biological Chemistry. 272 (31): 19457–63. doi:10.1074/jbc.272.31.19457. PMID 9235947.
^ Mattei MG, Tissot C, Gongora C, Mechti N (Jun 1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization". Cytogenetics and Cell Genetics. 79 (3–4): 286–7. doi:10.1159/000134745. PMID 9605874.
^ "Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa".

Pentecost BT (Jan 1998). "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus". The Journal of Steroid Biochemistry and Molecular Biology. 64 (1–2): 25–33. doi:10.1016/S0960-0760(97)00140-4. PMID 9569007. S2CID 23325745.
Nguyen LH, Espert L, Mechti N, Wilson DM (Jun 2001). "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro". Biochemistry. 40 (24): 7174–9. doi:10.1021/bi010141t. PMID 11401564.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N (May 2003). "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses". The Journal of Biological Chemistry. 278 (18): 16151–8. doi:10.1074/jbc.M209628200. PMID 12594219.
Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T (Nov 2004). "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease". FEBS Letters. 577 (1–2): 111–6. doi:10.1016/j.febslet.2004.09.074. PMID 15527770.