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PTPLAD1 - Wikipedia

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HACD3

Identifiers

HACD3, B-IND1, BIND1, HSPC121, PTPLAD1, 3-hydroxyacyl-CoA dehydratase 3

External IDs

OMIM: 615940; MGI: 1889341; HomoloGene: 9494; GeneCards: HACD3; OMA:HACD3 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q22.31	Start	65,530,418 bp^[1]
End	65,578,349 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 C	Start	64,894,265 bp^[2]
End	64,928,975 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Pons

pars compacta

retinal pigment epithelium

renal medulla

superior vestibular nucleus

pars reticulata

lateral nuclear group of thalamus

ventral tegmental area

middle temporal gyrus

inferior ganglion of vagus nerve

Top expressed in

Paneth cell

substantia nigra

facial motor nucleus

pineal gland

motor neuron

fossa

condyle

vestibular sensory epithelium

suprachiasmatic nucleus

Pituitary Gland

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	GTPase activator activity protein binding lyase activity enzyme binding 3-hydroxyacyl-CoA dehydratase activity 3-hydroxy-lignoceroyl-CoA dehydratase activity 3-hydroxy-behenoyl-CoA dehydratase activity 3-hydroxy-arachidoyl-CoA dehydratase activity very-long-chain 3-hydroxyacyl-CoA dehydratase activity
Cellular component	integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane focal adhesion endoplasmic reticulum mitochondrion cytosol integral component of endoplasmic reticulum membrane
Biological process	positive regulation by virus of viral protein levels in host cell lipid metabolism small GTPase mediated signal transduction fatty acid metabolic process JNK cascade fatty acid biosynthetic process very long-chain fatty acid biosynthetic process Rho protein signal transduction fatty acid elongation positive regulation of viral genome replication Rac protein signal transduction I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity sphingolipid biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51495


57874

Ensembl


ENSG00000074696


ENSMUSG00000033629

UniProt


Q9P035


Q8K2C9

RefSeq (mRNA)


NM_016395


NM_021345

RefSeq (protein)


NP_057479


NP_067320

Location (UCSC)

Chr 15: 65.53 – 65.58 Mb

Chr 9: 64.89 – 64.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein tyrosine phosphatase-like protein PTPLAD1 is an enzyme that in humans is encoded by the PTPLAD1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074696 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033629 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Courilleau D, Chastre E, Sabbah M, Redeuilh G, Atfi A, Mester J (Jul 2000). "B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts". J Biol Chem. 275 (23): 17344–8. doi:10.1074/jbc.M000887200. PMID 10747961.
^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
^ "Entrez Gene: PTPLAD1 protein tyrosine phosphatase-like A domain containing 1".

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