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RBP2 - Wikipedia

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RBP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2RCQ, 2RCT, 4EDE, 4EEJ, 4EFG, 4EXZ, 4GKC, 4QYN, 4QYP, 4QZT, 4QZU, 4RUU, 4ZGU, 4ZH9, 4ZCB, 4ZH6, 4ZJ0, 4ZR2

Identifiers

Aliases

RBP2, CRABP-II, CCRBPII, RBPC2, retinol binding protein 2

External IDs

OMIM: 180280; MGI: 97877; HomoloGene: 3070; GeneCards: RBP2; OMA:RBP2 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q23	Start	139,452,884 bp^[1]
End	139,480,747 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 E3.3\|9 51.37 cM	Start	98,368,168 bp^[2]
End	98,391,834 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

mucosa of ileum

duodenum

buccal mucosa cell

testicle

right lung

amniotic fluid

right uterine tube

mucosa of transverse colon

upper lobe of left lung

Top expressed in

duodenum

esophagus

pyloric antrum

jejunum

ileum

mucous cell of stomach

yolk sac

migratory enteric neural crest cell

corneal stroma

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	lipid binding retinol binding retinoid binding retinal binding
Cellular component	cytoplasm cytosol
Biological process	retinoid metabolic process epidermis development vitamin A metabolic process transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5948


19660

Ensembl


ENSG00000114113


ENSMUSG00000032454

UniProt


P50120


Q08652

RefSeq (mRNA)


NM_004164


NM_009034

RefSeq (protein)


NP_004155


NP_033060

Location (UCSC)

Chr 3: 139.45 – 139.48 Mb

Chr 9: 98.37 – 98.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene.^[5]^[6]^[7]

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114113 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032454 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (Oct 1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle". Hum Reprod. 10 (5): 1297–304. doi:10.1093/oxfordjournals.humrep.a136137. PMID 7657783.
^ De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L (Mar 1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 240–1. doi:10.1159/000015191. PMID 10072590. S2CID 22941923.
^ ^a ^b "Entrez Gene: RBP2 retinol binding protein 2, cellular".

van Eijk HG, Tio TH, Bos G (1975). "Iron in skin biopsies". Archiv für Dermatologische Forschung. 251 (3): 245–8. doi:10.1007/BF00561766. PMID 1115525. S2CID 11716439.
Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. doi:10.1021/bi00144a014. PMID 1322170.
Colantuoni V, Cortese R, Nilsson M, Lundvall J, Båvik CO, Eriksson U, Peterson PA, Sundelin J (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID 2992469.
Demmer LA, Birkenmeier EH, Sweetser DA, Levin MS, Zollman S, Sparkes RS, Mohandas T, Lusis AJ, Gordon JI (1987). "The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene". J. Biol. Chem. 262 (6): 2458–67. doi:10.1016/S0021-9258(18)61526-1. PMID 3029082.
Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710–5. Bibcode:2001PNAS...98.3710F. doi:10.1073/pnas.061455898. PMC 31117. PMID 11274389.
Chan SW, Hong W (2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription". J. Biol. Chem. 276 (30): 28402–12. doi:10.1074/jbc.M100313200. PMID 11358960.
Zhang L, E X, Luker KE, Shao JS, Levin MS, Suh E, Li E (2002). "Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (6): G1079–87. doi:10.1152/ajpgi.00041.2001. PMID 12016134. S2CID 21279637.

PDBe-KB provides an overview of all the structure information available in the PDB for Human Retinol-binding protein 2 (RBP2)