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60S ribosomal protein L4 - Wikipedia

From Wikipedia, the free encyclopedia

RPL4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4UG0, 4V6X, 5AJ0, 4UJD, 5A8L, 4D67, 4D5Y, 4UJE, 4UJC

Identifiers

Aliases

RPL4, L4, Ribosomal protein L4

External IDs

OMIM: 180479; MGI: 1915141; HomoloGene: 748; GeneCards: RPL4; OMA:RPL4 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q22.31	Start	66,498,015 bp^[1]
End	66,524,532 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 C	Start	64,080,657 bp^[2]
End	64,085,948 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

embryo

ganglionic eminence

cartilage tissue

ventricular zone

vulva

tail of epididymis

glutes

smooth muscle tissue

superficial temporal artery

caput epididymis

Top expressed in

tail of embryo

genital tubercle

epiblast

ovary

blastocyst

ventricular zone

ganglionic eminence

uterus

embryo

urinary bladder

More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	protein binding structural constituent of ribosome RNA binding
Cellular component	cytoplasm cytosol ribosome membrane focal adhesion nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus rough endoplasmic reticulum ribonucleoprotein complex
Biological process	protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing cytoplasmic translation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6124


67891

Ensembl


ENSG00000174444


ENSMUSG00000032399

UniProt


P36578


Q9D8E6

RefSeq (mRNA)


NM_000968


NM_024212

RefSeq (protein)


NP_000959


NP_077174

Location (UCSC)

Chr 15: 66.5 – 66.52 Mb

Chr 9: 64.08 – 64.09 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174444 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032399 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ Bagni C, Mariottini P, Annesi F, Amaldi F (Feb 1994). "Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein". Biochim Biophys Acta. 1216 (3): 475–8. doi:10.1016/0167-4781(93)90017-8. PMID 8268230.
^ ^a ^b "Entrez Gene: RPL4 ribosomal protein L4".

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