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Monocarboxylate transporter 9 - Wikipedia

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SLC16A9

Identifiers

Aliases

SLC16A9, C10orf36, MCT9, solute carrier family 16 member 9

External IDs

OMIM: 614242; MGI: 1914109; HomoloGene: 32642; GeneCards: SLC16A9; OMA:SLC16A9 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q21.2	Start	59,650,764 bp^[1]
End	59,736,002 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 B5.3	Start	70,080,930 bp^[2]
End	70,121,798 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left adrenal cortex

right adrenal cortex

nasal epithelium

mucosa of colon

mucosa of sigmoid colon

mucosa of ileum

human kidney

gums

gingival epithelium

ventricular zone

Top expressed in

retinal pigment epithelium

meninges

right lung

human kidney

right kidney

right lung lobe

proximal tubule

ciliary body

lumbar spinal ganglion

aortic valve

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding symporter activity monocarboxylic acid transmembrane transporter activity
Cellular component	plasma membrane membrane integral component of membrane integral component of plasma membrane
Biological process	urate metabolic process transmembrane transport monocarboxylic acid transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


220963


66859

Ensembl


ENSG00000165449


ENSMUSG00000037762

UniProt


Q7RTY1


Q7TM99

RefSeq (mRNA)

NM_194298 NM_001323977 NM_001323978 NM_001323979 NM_001323980
NM_001323981


NM_025807

RefSeq (protein)

NP_001310906 NP_001310907 NP_001310908 NP_001310909 NP_001310910
NP_919274


NP_080083

Location (UCSC)

Chr 10: 59.65 – 59.74 Mb

Chr 10: 70.08 – 70.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Monocarboxylate transporter 9 (MCT9, solute carrier family 16, member 9, SLC16A9) is a protein that in humans is encoded by the SLC16A9 gene.^[5]

Mutations in the SLC16A9 gene have been associated with carnitine levels in blood.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165449 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037762 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 16".
^ Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C, Assimes TL, Deloukas P, Erdmann J, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Schunkert H, Stewart AF (September 2011). "Human metabolic individuality in biomedical and pharmaceutical research". Nature. 477 (7362): 54–60. Bibcode:2011Natur.477...54S. doi:10.1038/nature10354. PMC 3832838. PMID 21886157.

Kolz M, Johnson T, Sanna S, et al. (2009). "Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations". PLOS Genet. 5 (6): e1000504. doi:10.1371/journal.pgen.1000504. PMC 2683940. PMID 19503597.
Gunjaca G; Boban M; PehliÄ‡ M; et al. (2010). "Predictive value of 8 genetic loci for serum uric acid concentration". Croat. Med. J. 51 (1): 23–31. doi:10.3325/cmj.2010.51.23. PMC 2829178. PMID 20162742.
Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Polasek O; JeronciÄ‡ I; MuliÄ‡ R; et al. (2010). "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. doi:10.3325/cmj.2010.51.32. PMC 2829186. PMID 20162743.
Stark K, Reinhard W, Grassl M, et al. (2009). "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE. 4 (11): e7729. Bibcode:2009PLoSO...4.7729S. doi:10.1371/journal.pone.0007729. PMC 2766838. PMID 19890391.
van der Harst P, Bakker SJ, de Boer RA, et al. (2010). "Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms". Hum. Mol. Genet. 19 (2): 387–95. doi:10.1093/hmg/ddp489. PMID 19861489.
Illig T, Gieger C, Zhai G, et al. (2010). "A genome-wide perspective of genetic variation in human metabolism". Nat. Genet. 42 (2): 137–41. doi:10.1038/ng.507. PMC 3773904. PMID 20037589.
Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.