UBE2V1 - Wikipedia

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UBE2V1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A4D, 2C2V, 2HLW
Identifiers
Aliases	UBE2V1, CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A, ubiquitin conjugating enzyme E2 V1
External IDs	OMIM: 602995; MGI: 1913839; HomoloGene: 81888; GeneCards: UBE2V1; OMA:UBE2V1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 50,081,124 bp[1] End 50,115,959 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 87.44 cM Start 167,449,558 bp[2] End 167,474,015 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon superior frontal gyrus tonsil smooth muscle tissue placenta ganglionic eminence primary visual cortex bone marrow cells skin of leg monocyte Top expressed in tail of embryo epiblast Cortex of frontal lobe dentate gyrus of hippocampal formation granule cell superior frontal gyrus striatum of neuraxis neural tube urinary bladder ventricular zone primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin conjugating enzyme activity Cellular component cytoplasm cytosol ubiquitin conjugating enzyme complex UBC13-UEV1A complex ubiquitin ligase complex extracellular exosome nucleus nucleoplasm protein-containing complex Biological process protein polyubiquitination Fc-epsilon receptor signaling pathway protein K63-linked ubiquitination nucleotide-binding oligomerization domain containing signaling pathway positive regulation of transcription, DNA-templated stimulatory C-type lectin receptor signaling pathway regulation of DNA repair regulation of transcription, DNA-templated T cell receptor signaling pathway cell differentiation postreplication repair positive regulation of I-kappaB kinase/NF-kappaB signaling JNK cascade positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7335 66589 Ensembl ENSG00000244687 ENSMUSG00000078923 UniProt Q13404 Q9CZY3 RefSeq (mRNA) NM_001032288 NM_001257393 NM_001257394 NM_001257395 NM_001257396 NM_001257397 NM_001257398 NM_001257399 NM_001282575 NM_001282576 NM_001282577 NM_001282578 NM_001282579 NM_001282580 NM_021988 NM_022442 NM_199144 NM_023230 NM_001311131 NM_001311146 RefSeq (protein) NP_001027459 NP_001244322 NP_001244323 NP_001244324 NP_001244325 NP_001244326 NP_001244327 NP_001244328 NP_001269504 NP_001269505 NP_001269506 NP_001269507 NP_001269508 NP_001269509 NP_068823 NP_071887 NP_954595 NP_954673 NP_001298060 NP_001298075 NP_075719 Location (UCSC) Chr 20: 50.08 – 50.12 Mb Chr 2: 167.45 – 167.47 Mb PubMed search [3] [4]
Wikidata
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Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.^[5][6][7]

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.^[7]

UBE2V1 has been shown to interact with UBE2N.^[8]