enzyme.expasy.org

ENZYME - 1.1.1.159 7alpha-hydroxysteroid dehydrogenase

Accepted Name
7alpha-hydroxysteroid dehydrogenase
Reaction catalysed
cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+)
Comment(s)
  • Catalyzes the oxidation of the 7alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms.
  • The Bacteroides fragilis and Clostridium enzymes can also utilize NADP(+).
Cross-references
BRENDA1.1.1.159
EC2PDB1.1.1.159
ExplorEnz1.1.1.159
KEGG Ligand Database for Enzyme Nomenclature1.1.1.159
IUBMB Enzyme Nomenclature1.1.1.159
MEDLINEFind literature relating to 1.1.1.159
MetaCyc1.1.1.159
Rhea expert-curated reactions1.1.1.159
UniProtKB/Swiss-Prot
O02691, HCD2_BOVINQ99714, HCD2_HUMANO08756, HCD2_MOUSE
O70351, HCD2_RATQ5LA59, HDHA_BACFNP0AET9, HDHA_ECO57
P0AET8, HDHA_ECOLI

View entry in original ENZYME format
View entry in raw text format (no links)

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-