ENZYME - 1.11.2.1 unspecific peroxygenase

• Enzymes of this type include glycoproteins secreted by agaric basidiomycetes.
• They catalyze the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane.
• Reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations.
• They have little or no activity toward chloride.
• Mechanistically, the catalytic cycle of unspecific (mono)- peroxygenases combines elements of the 'shunt' pathway of cytochrome P450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.

B9W4V6, APO1_CYCAE