enzyme.expasy.org

ENZYME - 1.14.13.234 12-dehydrotetracycline 5-monooxygenase

Accepted Name
12-dehydrotetracycline 5-monooxygenase
Reaction catalysed
5a,11a-dehydrotetracycline + NADPH + O2 + H(+) = 5a,11a-dehydrooxytetracycline + NADP(+) + H2O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalyzing two successive monooxygenation reactions.
  • It starts by catalyzing the stereospecific hydroxylation of anhydrotetracycline at C(6) (EC 1.14.13.38).
  • If the released product is captured by EC 1.3.98.4 it is reduced to tetracycline.
  • However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C(5), producing 5a,11a- dehydrooxytetracycline, which, following the action of EC 1.3.98.4, becomes oxytetracycline.
Cross-references
BRENDA1.14.13.234
EC2PDB1.14.13.234
ExplorEnz1.14.13.234
KEGG Ligand Database for Enzyme Nomenclature1.14.13.234
IUBMB Enzyme Nomenclature1.14.13.234
MEDLINEFind literature relating to 1.14.13.234
MetaCyc1.14.13.234
Rhea expert-curated reactions1.14.13.234
UniProtKB/Swiss-Prot

L8EUQ6, OXYS_STRR1

View entry in original ENZYME format
View entry in raw text format (no links)

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-