enzyme.expasy.org

ENZYME - 1.14.14.14 aromatase

Accepted Name
aromatase
Alternative Name(s)
CYP19A1
estrogen synthetase
Reaction catalysed
  • testosterone + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 17beta-estradiol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
  • androst-4-ene-3,17-dione + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Comment(s)
The enzyme catalyzes three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively.
Cross-references
BRENDA1.14.14.14
EC2PDB1.14.14.14
ExplorEnz1.14.14.14
KEGG Ligand Database for Enzyme Nomenclature1.14.14.14
IUBMB Enzyme Nomenclature1.14.14.14
MEDLINEFind literature relating to 1.14.14.14
MetaCyc1.14.14.14
Rhea expert-curated reactions1.14.14.14
UniProtKB/Swiss-Prot
O42145, C19AA_DANREP79690, CP191_CARAUO73686, CP192_CARAU
P79430, CP192_PIGP79304, CP193_PIGQ6QHT9, CP19A_ANGJA
P46194, CP19A_BOVINQ95M61, CP19A_CALJAQ5QQX7, CP19A_CANLF
Q6YI21, CP19A_CAPHIP19098, CP19A_CHICKP79699, CP19A_COTJA
O46512, CP19A_HORSEP11511, CP19A_HUMANQ92111, CP19A_ICTPU
Q69FB6, CP19A_LAGACP28649, CP19A_MOUSEP70091, CP19A_ORENI
Q92087, CP19A_ORYLAQ29624, CP19A_PIGQ29605, CP19A_RABIT
P22443, CP19A_RATQ9XS28, CP19A_SHEEPQ92112, CP19A_TAEGU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-