| Accepted Name |
|---|
| pikromycin synthase
|
| Alternative Name(s) |
|---|
| CYP107L1 |
| Reaction catalysed |
|---|
- narbomycin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = pikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
- narbomycin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
- narbomycin + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O
- 10-deoxymethymycin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
- 10-deoxymethymycin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
- 10-deoxymethymycin + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O
|
| Comment(s) |
|---|
- A cytochrome P450 (heme-thiolate) protein.
- Involved in the biosynthesis of a number of bacterial macrolide
antibiotics containing a desosamine glycoside unit.
- With narbomycin it hydroxylates at either C-12 to give pikromycin or
C-14 to give neopikromycin or both positions to give narvopikromycin.
- With 10-deoxymethymycin it hydroxylates at either C-10 to give
methymycin or C-12 to give neomethymycin or both positions to give
novamethymycin.
- Formerly EC 1.14.13.185.
|
| Cross-references |
|---|
| BRENDA | 1.14.15.33 |
| EC2PDB | 1.14.15.33 |
| ExplorEnz | 1.14.15.33 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.33 |
| IUBMB Enzyme Nomenclature | 1.14.15.33 |
| MEDLINE | Find literature relating to 1.14.15.33 |
| MetaCyc | 1.14.15.33 |
| Rhea expert-curated reactions | 1.14.15.33 |
| UniProtKB/Swiss-Prot | O87605, PIKC_STRVZ
|
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