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ENZYME - 1.14.15.36 sterol 14alpha-demethylase (ferredoxin)

Accepted Name
sterol 14alpha-demethylase (ferredoxin)
Alternative Name(s)
CYP51
Reaction catalysed
a 14alpha-methyl steroid + 6 reduced [2Fe-2S]-[ferredoxin] + 3 O2 + 5 H(+) = a Delta(14) steroid + formate + 6 oxidized [2Fe-2S]-[ferredoxin] + 4 H2O
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in several bacterial species.
  • The enzyme, which is involved in sterol biosynthesis, catalyzes a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
  • The enzyme from Methylococcus capsulatus is fused to the ferredoxin by an alanine-rich linker. cf. EC 1.14.14.154.
Cross-references
BRENDA1.14.15.36
EC2PDB1.14.15.36
ExplorEnz1.14.15.36
PRIAM enzyme-specific profiles1.14.15.36
KEGG Ligand Database for Enzyme Nomenclature1.14.15.36
IUBMB Enzyme Nomenclature1.14.15.36
IntEnz1.14.15.36
MEDLINEFind literature relating to 1.14.15.36
MetaCyc1.14.15.36
Rhea expert-curated reactions1.14.15.36
UniProtKB/Swiss-Prot
P0A513, CP51_MYCBOP9WPP8, CP51_MYCTOP9WPP9, CP51_MYCTU
Q5IZM4, CP51_MYCVP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-