enzyme.expasy.org

ENZYME - 1.14.99.65 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase

Accepted Name
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
Reaction catalysed
4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces venezuelae, participates in the biosynthesis of the antibiotic chloramphenicol.
  • It carries an oxygen-bridged dinuclear iron cluster.
  • The native electron donor remains unknown, and the enzyme was assayed in vitro using sodium dithionite.
  • The enzyme only acts on its substrate when it is loaded onto the peptidyl-carrier domain of the CmlP non-ribosomal peptide synthase.
Cross-references
BRENDA1.14.99.65
EC2PDB1.14.99.65
ExplorEnz1.14.99.65
KEGG Ligand Database for Enzyme Nomenclature1.14.99.65
IUBMB Enzyme Nomenclature1.14.99.65
MEDLINEFind literature relating to 1.14.99.65
MetaCyc1.14.99.65
Rhea expert-curated reactions1.14.99.65
UniProtKB/Swiss-Prot

F2RB80, CMLA_STRVP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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