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ENZYME - 1.20.4.4 arsenate reductase (thioredoxin)

Accepted Name
arsenate reductase (thioredoxin)
Reaction catalysed
arsenate + [thioredoxin]-dithiol + H(+) = arsenite + [thioredoxin]-disulfide + H2O
Comment(s)
  • The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin.
  • It has no activity with glutaredoxin (cf. EC 1.20.4.1).
  • Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds.
  • The enzyme also has the activity of EC 3.1.3.48.
Cross-references
BRENDA1.20.4.4
EC2PDB1.20.4.4
ExplorEnz1.20.4.4
KEGG Ligand Database for Enzyme Nomenclature1.20.4.4
IUBMB Enzyme Nomenclature1.20.4.4
MEDLINEFind literature relating to 1.20.4.4
MetaCyc1.20.4.4
Rhea expert-curated reactions1.20.4.4
UniProtKB/Swiss-Prot
Q74NT6, ARSC1_BACC1Q5HRI4, ARSC1_STAEQQ4LAB5, ARSC1_STAHJ
Q49WS7, ARSC1_STAS1Q735E5, ARSC2_BACC1Q5HKB7, ARSC2_STAEQ
Q4LAA8, ARSC2_STAHJQ49UH1, ARSC2_STAS1C3P101, ARSC_BACAA
C3LDK1, ARSC_BACACQ81NJ6, ARSC_BACANB7INE4, ARSC_BACC2
C1F0A7, ARSC_BACC3B7HWU2, ARSC_BACC7A7GP55, ARSC_BACCN
B9IRF0, ARSC_BACCQQ81BK3, ARSC_BACCRQ639D2, ARSC_BACCZ
Q6HGP0, ARSC_BACHKQ65IV4, ARSC_BACLDP45947, ARSC_BACSU
C0ZEV2, ARSC_BREBNA4INR2, ARSC_GEOTNQ9K8K8, ARSC_HALH5
B9E7M5, ARSC_MACCJQ8ENQ5, ARSC_OCEIHQ8GJ74, ARSC_PRIM3
Q5WJS9, ARSC_SHOC1Q2FFW6, ARSC_STAA3Q2FXF5, ARSC_STAA8
Q2YTL3, ARSC_STAABQ5HF01, ARSC_STAACA6QHV6, ARSC_STAAE
P0A005, ARSC_STAANQ6GIZ3, ARSC_STAARA8Z4K0, ARSC_STAAT
P0A006, ARSC_STAAUQ8CQF5, ARSC_STAESQ01257, ARSC_STAXY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.20.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.20.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-