enzyme.expasy.org

ENZYME - 1.21.98.4 PqqA peptide cyclase

Accepted Name
PqqA peptide cyclase
Reaction catalysed
[PQQ precursor protein] + S-adenosyl-L-methionine = E-Y cross-linked-[PQQ precursor protein] + 5'-deoxyadenosine + L-methionine + H(+)
Comment(s)
  • This bacterial enzyme, which is a member of the radical SAM protein family, catalyzes the formation of a C-C bond between C-4 of glutamate and C-3 of tyrosine residues of the PqqA protein (which are separated by three amino acid residues).
  • This is the first enzymic step in the biosynthesis of the bacterial enzyme cofactor pyrroloquinoline quinone (PQQ).
  • The reaction is dependent on the presence of flavodoxin and the accessory protein PqqD.
Cross-references
BRENDA1.21.98.4
EC2PDB1.21.98.4
ExplorEnz1.21.98.4
PRIAM enzyme-specific profiles1.21.98.4
KEGG Ligand Database for Enzyme Nomenclature1.21.98.4
IUBMB Enzyme Nomenclature1.21.98.4
IntEnz1.21.98.4
MEDLINEFind literature relating to 1.21.98.4
MetaCyc1.21.98.4
Rhea expert-curated reactions1.21.98.4
UniProtKB/Swiss-Prot
Q6F9I9, PQQE_ACIADB7H2Y0, PQQE_ACIB3B7I6M8, PQQE_ACIB5
B2I0I5, PQQE_ACIBCB0VQD7, PQQE_ACIBSB0V494, PQQE_ACIBY
P07782, PQQE_ACICAC1DEW5, PQQE_AZOVDQ89FG1, PQQE_BRADU
A4XTR4, PQQE_ECTM1B2VL10, PQQE_ERWT9Q9L3B0, PQQE_GLUOX
Q0BQS8, PQQE_GRABCB5XX58, PQQE_KLEP3A6T9H2, PQQE_KLEP7
P27507, PQQE_KLEPNP59748, PQQE_KLUINB7KXC6, PQQE_METC4
Q608P0, PQQE_METCAP71517, PQQE_METEAA9W3R0, PQQE_METEP
B8ITV7, PQQE_METNOB1ZIB2, PQQE_METPBB1LUE7, PQQE_METRJ
B0UE13, PQQE_METS4B8ENI9, PQQE_METSBQ48CT3, PQQE_PSE14
B7VAB6, PQQE_PSEA8Q02LD6, PQQE_PSEABQ9I2C0, PQQE_PSEAE
Q4K4U8, PQQE_PSEF5A5VXG4, PQQE_PSEP1Q88QV8, PQQE_PSEPK
Q88A84, PQQE_PSESMQ4ZMC1, PQQE_PSEU2Q01060, PQQE_PSEVU
O33506, PQQE_RAHAQQ9EXU8, PQQE_RHIMEQ6N8F3, PQQE_RHOPA
Q5LTB4, PQQE_RUEPOP59749, PQQE_STRROQ8PHY1, PQQE_XANAC
Q4UXI4, PQQE_XANC8B0RQ25, PQQE_XANCBQ8P6M7, PQQE_XANCP
Q3BQI4, PQQE_XANE5Q2P4Y9, PQQE_XANOMB2SSW3, PQQE_XANOP
Q5H234, PQQE_XANOR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.98.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-