enzyme.expasy.org

ENZYME - 1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))

Accepted Name
3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))
Alternative Name(s)
3-oxo-5alpha-steroid 4-dehydrogenase
cholestenone 5alpha-reductase
Reaction catalysed
a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)
Comment(s)
  • The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4) steroids into their corresponding 5alpha form.
  • Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone.
  • Substrates for the plant enzyme are brassinosteroids such as campest- 4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5.
  • Formerly EC 1.3.1.4 and EC 1.3.1.30.
Cross-references
BRENDA1.3.1.22
EC2PDB1.3.1.22
ExplorEnz1.3.1.22
KEGG Ligand Database for Enzyme Nomenclature1.3.1.22
IUBMB Enzyme Nomenclature1.3.1.22
MEDLINEFind literature relating to 1.3.1.22
MetaCyc1.3.1.22
Rhea expert-curated reactions1.3.1.22
UniProtKB/Swiss-Prot
Q38944, DET2_ARATHI1HTF7, DET2_BRADIQ2QDF6, DET2_GOSHI
Q5K2N1, DET2_SOLLCA5PJS2, S5A1_BOVINP18405, S5A1_HUMAN
Q28891, S5A1_MACFAQ68FF9, S5A1_MOUSEP24008, S5A1_RAT
P31213, S5A2_HUMANQ28892, S5A2_MACFAQ99N99, S5A2_MOUSE
O18765, S5A2_PIGP31214, S5A2_RATD2HBV9, SR5A3_AILME
Q5RIU9, SR5A3_DANREQ9H8P0, SR5A3_HUMANC7T2J9, SR5A3_MESAU
Q9WUP4, SR5A3_MOUSEQ5RJM1, SR5A3_RATQ8AVI9, SR5A3_XENLA
Q0P4J9, SR5A3_XENTR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-