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ENZYME - 1.3.7.5 phycocyanobilin:ferredoxin oxidoreductase

Accepted Name
phycocyanobilin:ferredoxin oxidoreductase
Reaction catalysed
(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 reduced [2Fe-2S]-[ferredoxin] + 4 H(+)
Comment(s)
  • Catalyzes the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings).
  • Reaction proceeds via an isolatable 2-electron intermediate, 18(1),18(2)-dihydrobiliverdin.
  • Flavodoxins can be used instead of ferredoxin.
  • The direct conversion of biliverdin IXalpha (BV) to (3Z)- phycocyanobilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.
Cross-references
BRENDA1.3.7.5
EC2PDB1.3.7.5
ExplorEnz1.3.7.5
KEGG Ligand Database for Enzyme Nomenclature1.3.7.5
IUBMB Enzyme Nomenclature1.3.7.5
MEDLINEFind literature relating to 1.3.7.5
MetaCyc1.3.7.5
Rhea expert-curated reactions1.3.7.5
UniProtKB/Swiss-Prot
B1X018, PCYA_CROS5B7KJQ2, PCYA_GLOC7Q7NHE8, PCYA_GLOVI
B0JPG5, PCYA_MICANQ93TM9, PCYA_NOSP7Q93TN0, PCYA_NOSS1
Q7U7A1, PCYA_PARMWA3PCF5, PCYA_PROM0A8G4C5, PCYA_PROM2
A2CA92, PCYA_PROM3A2BW83, PCYA_PROM5Q31BD0, PCYA_PROM9
Q7VCC2, PCYA_PROMAQ7V7Y8, PCYA_PROMMQ93TL5, PCYA_PROMP
A2BQN3, PCYA_PROMSB7JWS2, PCYA_RIPO1Q8KPS9, PCYA_SYNE7
Q5N5A3, PCYA_SYNP6Q3AXI3, PCYA_SYNS9Q3AKB1, PCYA_SYNSC
Q55891, PCYA_SYNY3P59288, PCYA_THEVBQ10X61, PCYA_TRIEI
Q3M745, PCYA_TRIV2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-