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ENZYME - 2.5.1.48 cystathionine gamma-synthase

Accepted Name
cystathionine gamma-synthase
Alternative Name(s)
cystathionine synthase
cystathionine synthetase
homoserine transsuccinylase
O-succinylhomoserine (thiol)-lyase
O-succinylhomoserine synthase
O-succinylhomoserine synthetase
O-succinyl-L-homoserine succinate-lyase (adding cysteine)
Reaction catalysed
O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)
Comment(s)
  • Also reacts with H2S and methanethiol as replacing agents, producing homocysteine and methionine, respectively.
  • In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
  • Formerly EC 4.2.99.9.
Cross-references
BRENDA2.5.1.48
EC2PDB2.5.1.48
ExplorEnz2.5.1.48
KEGG Ligand Database for Enzyme Nomenclature2.5.1.48
IUBMB Enzyme Nomenclature2.5.1.48
MEDLINEFind literature relating to 2.5.1.48
MetaCyc2.5.1.48
Rhea expert-curated reactions2.5.1.48
UniProtKB/Swiss-Prot
P55217, CGS1_ARATHQ9C876, CGS2_ARATHP38675, MET7_NEUCR
O74314, MET7_SCHPOP47164, MET7_YEASTP00935, METB_ECOLI
P44502, METB_HAEINQ9ZMW7, METB_HELPJQ1M0P5, METB_HELPX
P56069, METB_HELPYP24601, METB_HERAUP66876, METB_MYCBO
P46807, METB_MYCLEP9WGB6, METB_MYCTOP9WGB7, METB_MYCTU
Q04533, METX_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-