enzyme.expasy.org

ENZYME - 3.1.3.71 2-phosphosulfolactate phosphatase

Accepted Name
2-phosphosulfolactate phosphatase
Alternative Name(s)
(2R)-phosphosulfolactate phosphohydrolase
ComB phosphatase
Reaction catalysed
(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate
Comment(s)
  • The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyzes a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate.
  • This enzyme can also hydrolyze phosphate monoesters of (R)-2- hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)- 2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations.
Cross-references
BRENDA3.1.3.71
EC2PDB3.1.3.71
ExplorEnz3.1.3.71
PRIAM enzyme-specific profiles3.1.3.71
KEGG Ligand Database for Enzyme Nomenclature3.1.3.71
IUBMB Enzyme Nomenclature3.1.3.71
IntEnz3.1.3.71
MEDLINEFind literature relating to 3.1.3.71
MetaCyc3.1.3.71
Rhea expert-curated reactions3.1.3.71
UniProtKB/Swiss-Prot
O06738, COMB_BACSUQ8R8M3, COMB_CALS4A4XFZ6, COMB_CALS8
Q3AD96, COMB_CARHZQ97E82, COMB_CLOABA7FPH4, COMB_CLOB1
C3KWA9, COMB_CLOB6A6LPF0, COMB_CLOB8B2UX99, COMB_CLOBA
B2THU3, COMB_CLOBBC1FNF9, COMB_CLOBJB1IH09, COMB_CLOBK
A7GJE7, COMB_CLOBLB1KTF5, COMB_CLOBMB9DY39, COMB_CLOK1
A5N4H7, COMB_CLOK5A0Q380, COMB_CLONNQ0TM95, COMB_CLOP1
Q8XHC9, COMB_CLOPEQ0SPZ8, COMB_CLOPSQ899J5, COMB_CLOTE
B8HW27, COMB_CYAP4C1D1F5, COMB_DEIDVQ1IYS0, COMB_DEIGD
Q9RUI6, COMB_DEIRAB7K825, COMB_GLOC7Q7NCK4, COMB_GLOVI
Q58540, COMB_METJAO27250, COMB_METTHB0JV88, COMB_MICAN
B2IVU1, COMB_NOSP7Q8YTZ5, COMB_NOSS1Q7U7H6, COMB_PARMW
B1XQ41, COMB_PICP2A2C172, COMB_PROM1A2CAX3, COMB_PROM3
Q7VBP6, COMB_PROMAQ7V8F6, COMB_PROMMQ46LT5, COMB_PROMT
A8F5X7, COMB_PSELTB7JUJ9, COMB_RIPO1Q9F3E6, COMB_STRCO
Q67NP7, COMB_SYMTHQ2JWJ9, COMB_SYNJAQ2JPJ7, COMB_SYNJB
A5GKJ5, COMB_SYNPWA5GT49, COMB_SYNR3Q0I9X0, COMB_SYNS3
Q3AXB9, COMB_SYNS9Q3AKJ4, COMB_SYNSCP73849, COMB_SYNY3
Q9HIA9, COMB_THEACQ9WZQ4, COMB_THEMAA5IIY7, COMB_THEP1
Q72IQ9, COMB_THET2Q5SID6, COMB_THET8Q8DLS5, COMB_THEVB
Q97CK6, COMB_THEVOQ116L2, COMB_TRIEIQ3MFW5, COMB_TRIV2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-