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ENZYME - 4.1.2.55 aldolase

Accepted Name
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Alternative Name(s)
2-keto-3-deoxygluconate aldolase
Reaction catalysed
  • 2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate
  • 2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate
Comment(s)
  • In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway.
  • It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro- 3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency.
  • In vitro the enzyme can also catalyze the cleavage of the non- phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.14 and EC 4.1.2.21.
Cross-references
BRENDA4.1.2.55
EC2PDB4.1.2.55
ExplorEnz4.1.2.55
KEGG Ligand Database for Enzyme Nomenclature4.1.2.55
IUBMB Enzyme Nomenclature4.1.2.55
MEDLINEFind literature relating to 4.1.2.55
MetaCyc4.1.2.55
Rhea expert-curated reactions4.1.2.55
UniProtKB/Swiss-Prot
Q97U28, KDGA_SACS2O54288, KDGA_SACSOQ4JC35, KDGA_SULAC
F9VPG1, KDGA_SULTO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-