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ENZYME - 4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

Accepted Name
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
Alternative Name(s)
F0-synthase
FO synthase
Reaction catalysed
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 5'-deoxyadenosine + L-methionine + NH4(+) + H(+)
Comment(s)
  • The enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F0) precursor of factor 420 (coenzyme F420), a metabolite found in methanogens and in various actinobacteria.
  • F0 is also produced by some cyanobacteria and eukaryotes.
  • The enzyme, which forms a complex with EC 2.5.1.147, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to catalyze the condensation reaction.
  • Formerly EC 2.5.1.77.
Cross-references
BRENDA4.3.1.32
EC2PDB4.3.1.32
ExplorEnz4.3.1.32
KEGG Ligand Database for Enzyme Nomenclature4.3.1.32
IUBMB Enzyme Nomenclature4.3.1.32
MEDLINEFind literature relating to 4.3.1.32
MetaCyc4.3.1.32
Rhea expert-curated reactions4.3.1.32
UniProtKB/Swiss-Prot
O29461, COFG_ARCFUQ7NIT2, COFG_GLOVIQ5UXN0, COFG_HALMA
B0R6P8, COFG_HALS3Q9HNU9, COFG_HALSAA6UVH0, COFG_META3
Q8TQP9, COFG_METACA7IAF4, COFG_METB6Q466A4, COFG_METBF
Q12WF6, COFG_METBUQ57888, COFG_METJAQ8TWY3, COFG_METKA
A4FXR1, COFG_METM5A9AB67, COFG_METM6A6VFG8, COFG_METM7
Q8PU55, COFG_METMAA3CWL4, COFG_METMJQ6LYV9, COFG_METMP
B8GGS3, COFG_METPEA5UM12, COFG_METS3O27266, COFG_METTH
A0B5P5, COFG_METTPA6UN87, COFG_METVSQ8YR77, COFG_NOSS1
Q31PU7, COFG_SYNE7Q5N4D1, COFG_SYNP6P73191, COFG_SYNY3
Q8DIR6, COFG_THEVBQ11A09, COFG_TRIEIQ3MCR5, COFG_TRIV2
Q7U0G9, FBIC_MYCBOQ9CBX6, FBIC_MYCLEQ73WP9, FBIC_MYCPA
P9WP76, FBIC_MYCTOP9WP77, FBIC_MYCTUQ5YQD7, FBIC_NOCFA
Q82GV2, FBIC_STRAWQ9KZZ7, FBIC_STRCO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-