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ENZYME - 4.4.1.38 isethionate sulfite-lyase

Accepted Name
isethionate sulfite-lyase
Reaction catalysed
2-hydroxyethane-1-sulfonate = acetaldehyde + sulfite + H(+)
Comment(s)
  • The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production.
  • The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.
Cross-references
BRENDA4.4.1.38
EC2PDB4.4.1.38
ExplorEnz4.4.1.38
KEGG Ligand Database for Enzyme Nomenclature4.4.1.38
IUBMB Enzyme Nomenclature4.4.1.38
MEDLINEFind literature relating to 4.4.1.38
MetaCyc4.4.1.38
Rhea expert-curated reactions4.4.1.38
UniProtKB/Swiss-Prot
E5Y378, ISLA_BILW3B8J0R1, ISLA_DESDAQ727N1, ISLA_NITV2
Q312S2, ISLA_OLEA2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-