connect.h1.co

Targeting CDK4 (cyclin-dependent k ... | Article | H1 Connect

Evaluations

Cyclin-dependent kinase 4 (CDK4) amplification is present in over 90% of well-differentiated liposarcoma and dedifferentiated liposarcoma. This article presents a useful summary of its role in driving the overexpression of CDK4 and cell cycle progression through dysregulated phosphorylation of retinoblastoma (Rb) protein.

This Recommendation is of an article referenced in a Faculty Review also written by Richard Riedel.

Relevant Specialties

  • Cancer Biology

    Cell Growth & Division

  • Cell Biology

    Cell Growth & Division | Control of Gene Expression

  • Genomics & Genetics

    Control of Gene Expression

  • Molecular Biology

    Control of Gene Expression

  • Molecular Medicine

    Cell Growth & Division

  • Oncology

    Sarcomas

Clinical Trials