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Preoperative radiotherapy plus sur ... | Article | H1 Connect

Classifications

  • New Finding

Evaluations

While well-differentiated liposarcoma (WDLPS) rarely metastasizes, local recurrence of both retroperitoneal (RP) WDLPS and dedifferentiated liposarcoma (DDLPS) causes morbidity and impacts overall survival (OS), and thus efforts to improve local control are key. This prospective, multicenter phase III randomized controlled trial—the STRASS trial (EORTC 62092)—is the only completed trial to prospectively evaluate the impact of perioperative radiation therapy compared to surgery alone in RP soft tissue sarcoma. This trial randomized 266 patients with RP sarcoma (74.5% with liposarcoma, 97% of which were WDLPS/DDLPS) to preoperative radiotherapy followed by surgery or surgery alone and demonstrated a similar 3-year abdominal recurrence-free survival between the two arms (60.4% versus 58.7%, respectively) in the entire study population and in an exploratory post-hoc analysis of patients with liposarcoma.

This Recommendation is of an article referenced in a Faculty Review also written by Richard Riedel.

Relevant Specialties

  • Oncology

    Sarcomas

Clinical Trials

Trial registry title:
Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma
Identifier:
NCT01344018

Sponsor:

European Organisation for Research and Treatment of Cancer - EORTC
Phase:
N/A
Gender:
All
Min Age:
18 Years
Max Age:
120 Years
Condition:
Sarcoma
Interventions:
therapeutic conventional surgery, 3-dimensional conformal radiation therapy
Countries:
Belgium, Canada, Denmark, France, Germany, Italy, Netherlands, Norway, Poland, Spain, Sweden, United Kingdom, United States
Official Title:
A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS)

Full Registry Information