Base-stacking and base-pairing con ... | Article | H1 Connect
Yakovchuk P et al.
Nucleic Acids Research. 2006; 34(2):564-574
https://doi.org/10.1093/nar/gkj454PMID: 16449200Evaluations
This interesting paper provides novel measurements that indicate that DNA base-stacking interactions are the predominant force that stabilizes the DNA double helix. The authors separate the base pairing and stacking contributions to thermal stability of the double helix by studying PAGE of DNA molecules with single nicks and gaps. The different stacking interactions account for at least half of the stability differences between A:T and G:C polymers.
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